| Author | Van den Broeck, Frederik | |
| Author | Savill, Nicholas J. | |
| Author | Imamura, Hideo | |
| Author | Sanders, Mandy | |
| Author | Maes, Ilse | |
| Author | Cooper, Sinclair | |
| Author | Mateus, David | |
| Author | Jara, Marlene | |
| Author | Adaul, Vanessa | |
| Author | Arevalo, Jorge | |
| Author | Llanos-Cuentas, Alejandro | |
| Author | Garcia, Lineth | |
| Author | Cupolillo, Elisa | |
| Author | Miles, MIchael | |
| Author | Berriman, Matthew | |
| Author | Schnaufer, Achim | |
| Author | Cottori, James A. | |
| Author | Dujardin, Jean-Claude | |
| Access date | 2021-01-09T14:46:52Z | |
| Available date | 2021-01-09T14:46:52Z | |
| Document date | 2020 | |
| Citation | VAN DEN BROECK, Frederik et al, Ecological divergence and hybridization of Neotropical Leishmania parasites. PNAS, v. 117, n. 40, p. 25159-15168, Oct. 2020. | pt_BR |
| ISSN | 0027-8424 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/45541 | |
| Language | eng | pt_BR |
| Publisher | National Academy of Sciences | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Genômica de especiação | pt_BR |
| Subject in Portuguese | Especiação ecológica | pt_BR |
| Subject in Portuguese | Genômica populacional | pt_BR |
| Subject in Portuguese | Doença transmitida por vetores | pt_BR |
| Subject in Portuguese | Hibridização interespecífica | pt_BR |
| Title | Ecological divergence and hybridization of Neotropical Leishmania parasites | pt_BR |
| Type | Article | |
| DOI | 10.1073/pnas.1920136117 | |
| Abstract | The tropical Andes are an important natural laboratory to understand
speciation in many taxa. Here we examined the evolutionary
history of parasites of the Leishmania braziliensis species
complex based on whole-genome sequencing of 67 isolates from
47 localities in Peru. We first show the origin of Andean Leishmania
as a clade of near-clonal lineages that diverged from
admixed Amazonian ancestors, accompanied by a significant reduction
in genome diversity and large structural variations implicated
in host–parasite interactions. Within the Andean species,
patterns of population structure were strongly associated with
biogeographical origin. Molecular clock and ecological niche modeling
suggested that the history of diversification of the Andean
lineages is limited to the Late Pleistocene and intimately associated
with habitat contractions driven by climate change. These
results suggest that changes in forestation over the past
150,000 y have influenced speciation and diversity of these Neotropical
parasites. Second, genome-scale analyses provided evidence
of meiotic-like recombination between Andean and
Amazonian Leishmania species, resulting in full-genome hybrids.
The mitochondrial genome of these hybrids consisted of homogeneous
uniparental maxicircles, but minicircles originated from both
parental species. We further show that mitochondrial minicircles—
but not maxicircles—show a similar evolutionary pattern to the
nuclear genome, suggesting that compatibility between nuclearencoded
mitochondrial genes and minicircle-encoded guide RNA
genes is essential to maintain efficient respiration. By comparing
full nuclear and mitochondrial genome ancestries, our data expand
our appreciation on the genetic consequences of diversification
and hybridization in parasitic protozoa. | pt_BR |
| Affilliation | Department of Biomedical Sciences, Institute of Tropical Medicine, 2000 Antwerp, Belgium / Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, 3000 Leuven, Belgium. | pt_BR |
| Affilliation | Institute of Immunology and Infection Research University of Edinburgh, EH8 9YL Edinburgh, United Kingdom. | pt_BR |
| Affilliation | Centre of Medical Genetics, Universitair Ziekenhuis Brussel, 1000 Brussels. Belgium. | pt_BR |
| Affilliation | Parasite Genomics Group, Wellcome Sanger Institute, CB10 Hinxton. United Kingdom. | pt_BR |
| Affilliation | Department of Biomedical Sciences, Institute of Tropical Medicine, 2000 Antwerp, Belgium. | pt_BR |
| Affilliation | Institute of Immunology and Infection Research University of Edinburgh, EH8 9YL Edinburgh, United Kingdom. | pt_BR |
| Affilliation | Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, WC1E 7HT London, United Kingdom. | pt_BR |
| Affilliation | Department of Biomedical Sciences, Institute of Tropical Medicine, 2000 Antwerp, Belgium / Instituto de Medicina Tropical Alexander von Humboldt. Cayetano Heredia University, 15000 Lima, Peru. | pt_BR |
| Affilliation | Instituto de Medicina Tropical Alexander von Humboldt. Cayetano Heredia University, 15000 Lima, Peru. | pt_BR |
| Affilliation | Instituto de Medicina Tropical Alexander von Humboldt. Cayetano Heredia University, 15000 Lima, Peru. | pt_BR |
| Affilliation | Instituto de Medicina Tropical Alexander von Humboldt. Cayetano Heredia University, 15000 Lima, Peru. | pt_BR |
| Affilliation | Instituto de Investigación Biomédicas e Investigación Social, Universidad Mayor de San Simon, 06651 Cochabamba, Bolivia. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, WC1E 7HT London, United Kingdom. | pt_BR |
| Affilliation | Parasite Genomics Group, Wellcome Sanger Institute, CB10 Hinxton, United Kingdom. | pt_BR |
| Affilliation | Institute of Immunology and Infection Research University of Edinburgh, EH8 9YL Edinburgh, United Kingdom. | pt_BR |
| Affilliation | Parasite Genomics Group, Wellcome Sanger Institute, CB10 Hinxton, United Kingdom. | pt_BR |
| Affilliation | Department of Biomedical Sciences, Institute of Tropical Medicine, 2000 Antwerp, Belgium / de Medicina Tropical Alexander von Humboldt, Cayetano Heredia University, 15000 Lima, Peru. | pt_BR |
| Subject | Speciation genomics | pt_BR |
| Subject | Ecological speciation | pt_BR |
| Subject | Population genomics | pt_BR |
| Subject | Vector-borne disease | pt_BR |
| Subject | Interspecific hybridization | pt_BR |
| e-ISSN | 1091-6490 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
