| Author | Hauser-Davis, Rachel Ann | |
| Author | Figueiredo, Livia | |
| Author | Lemos, Leila | |
| Author | Moura, Jailson Fulgêncio de | |
| Author | Rocha, Rafael C. C. | |
| Author | Saint Pierre, Tatiana | |
| Author | Ziolli, Roberta L. | |
| Author | Siciliano, Salvatore | |
| Access date | 2021-01-25T15:10:23Z | |
| Available date | 2021-01-25T15:10:23Z | |
| Document date | 2020 | |
| Citation | HAUSER-DAVIS, Rachel Ann et al. Subcellular Cadmium, Lead and Mercury Compartmentalization in Guiana Dolphins (Sotalia guianensis) From Southeastern Brazil. Frontiers in Marine Science, v. 7, Article 584195, p. 1-8, Dec. 2020. | pt_BR |
| ISSN | 2296-7745 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/45802 | |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Fracionamento metálico subcelular | pt_BR |
| Subject in Portuguese | Desintoxicação metálica | pt_BR |
| Subject in Portuguese | Biodisponibilidade | pt_BR |
| Subject in Portuguese | Contaminação | pt_BR |
| Title | Subcellular Cadmium, Lead and Mercury Compartmentalization in Guiana Dolphins (Sotalia guianensis) From Southeastern Brazil | pt_BR |
| Type | Article | |
| DOI | 10.3389/fmars.2020.584195 | |
| Abstract | Marine mammals are considered excellent ocean health sentinels and are ubiquitously
exposed to chemical contaminants worldwide. The Guiana dolphin (Sotalia guianensis)
is a near-threatened dolphin species from Brazil with unknown population size data.
This indicates the need for assessments regarding deleterious effects that may arise
from exposure to chemical contamination, especially metals. After entry in the organism,
these compounds are subject to internal subcellular compartmentalization, which in turn
alters their bioavailability. However, almost no assessments regarding subcellular metal
contents in marine mammals are available. In this context, metal compartmentalization
was determined in three subcellular fractions for three toxic elements, Cd, Hg and Pb,
by inductively coupled plasma mass spectrometry (ICP-MS) in Guiana dolphin kidney
and liver samples from Southeastern Brazil. Differential metal-detoxification mechanisms
were observed for the three elements, where metallothionein (MT) detoxification was
postulated for only for Pb, while Cd and Hg were poorly associated to MT, and mostly
present in the insoluble fraction, indicating low bioavailability. This is the first report on
subcellular metal compartmentalization in Guiana dolphins and indicates that critical
biochemical detoxification data is obtained through subcellular fraction analyses in
marine mammals. This indicates an emerging study field for this type of assessment,
which may, in turn, aid in conservation efforts. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental. Rio de Janeiro, RJ, Brasil / GEMM-Lagos. Araruama, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | GEMM-Lagos. Araruama, RJ, Brasil / Oregon State University. Mammal Institute. Hatfield Marine Science Center. Corvallis, OR, USA. | pt_BR |
| Affilliation | GEMM-Lagos. Araruama, RJ, Brasil / Leibniz Center for Tropical Marine Ecology (ZMT), Systems Ecology Group. Bremen, Germany. | pt_BR |
| Affilliation | Pontifícia Universidade Católica do Rio de Janeiro. Departamento de Química. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Pontifícia Universidade Católica do Rio de Janeiro. Departamento de Química. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | GEMM-Lagos. Araruama, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biodiversidade. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Odontocetes | pt_BR |
| Subject | Subcellular metal fractionation | pt_BR |
| Subject | Metal detoxification | pt_BR |
| Subject | Bioavailability | pt_BR |
| Subject | Contamination | pt_BR |
| xmlui.metadata.dc.subject.ods | 06 Água potável e saneamento | |
