Mostrar el registro sencillo del ítem
| Autor | Giandhari, Jennifer | |
| Autor | Pillay, Sureshnee | |
| Autor | Wilkinson, Eduan | |
| Autor | Tegally, Houriiyah | |
| Autor | Sinayskiy, Ilya | |
| Autor | Schuld, Maria | |
| Autor | Lourenço, José | |
| Autor | Chimukangara, Benjamin | |
| Autor | Lessells, Richard | |
| Autor | Moosa, Yunus | |
| Autor | Gazy, Inbal | |
| Autor | Fish, Maryam | |
| Autor | Singh, Lavanya | |
| Autor | Khanyile, Khulekani Sedwell | |
| Autor | Fonseca, Vagner de Souza | |
| Autor | Giovanetti, Marta | |
| Autor | Alcantara, Luiz Carlos Júnior | |
| Autor | Petruccione, Francesco | |
| Autor | Oliveira, Túlio de Paiva Nazareth Andrade de | |
| Fecha de acceso | 2021-01-26T14:16:53Z | |
| Fecha de disponibilización | 2021-01-26T14:16:53Z | |
| Fecha de publicación | 2021 | |
| Referencia | GIANDHARI, Jennifer et al. Early transmission of SARS-CoV-2 in South Africa: an epidemiological and phylogenetic report. International Journal of Infectious Diseases, v. 103, p. 234-241, Feb. 2021. | |
| ISSN | 1201-9712 | |
| URI | https://www.arca.fiocruz.br/handle/icict/45822 | |
| Descripción | Produção científica do Laboratório de Flavivírus (vigente até jan/2023). | pt_BR |
| Idioma | eng | en_US |
| Editor | Elsevier | |
| Versión posterior | https://www.arca.fiocruz.br/handle/icict/44445 | |
| Derechos de autor | open access | |
| Palabras clave en Portugués | SARS-CoV-2 | pt_BR |
| Palabras clave en Portugués | África do Sul | pt_BR |
| Palabras clave en Portugués | Epidemiologia | pt_BR |
| Palabras clave en Portugués | Sequenciamento da próxima geração | pt_BR |
| Palabras clave en Portugués | Phylogenetic | pt_BR |
| Palabras clave en Portugués | Genômica de transmissão | pt_BR |
| Palabras clave en Portugués | COVID-19 | pt_BR |
| Título | Early transmission of SARS-CoV-2 in South Africa: an epidemiological and phylogenetic report | en_US |
| Tipo del documento | Article | |
| DOI | 10.1016/j.ijid.2020.11.128 | |
| Resumen en Inglés | Objectives: The Network for Genomic Surveillance in South Africa (NGS-SA) was formed to investigate the introduction and understand the early transmission dynamics of the SARS-CoV-2 epidemic in South-Africa. Design: This paper presents the first results from this group, which is a molecular epidemiological study of the first 21 SARS-CoV-2 whole genomes sampled in the first port of entry – KwaZulu-Natal (KZN) – during the first month of the epidemic. By combining this with calculations of the effective reproduction number (R), it aimed to shed light on the patterns of infections in South Africa. Results: Two of the largest provinces – Gauteng and KZN – had a slow growth rate for the number of detected cases, while the epidemic spread faster in the Western Cape and Eastern Cape. The estimates of transmission potential suggested a decrease towards R = 1 since the first cases and deaths, but a subsequent estimated R average of 1.39 between 6–18 May 2020. It was also demonstrated that early transmission in KZN was associated with multiple international introductions and dominated by lineages B1 and B. Evidence for locally acquired infections in a hospital in Durban within the first month of the epidemic was also provided. Conclusion: The COVID-19 pandemic in South Africa was very heterogeneous in its spatial dimension, with many distinct introductions of SARS-CoV2 in KZN and evidence of nosocomial transmission, which inflated early mortality in KZN. The epidemic at the local level was still developing and NGS-SA aimed to clarify the dynamics in South Africa and devise the most effective measures as the outbreak evolved. | en_US |
| Afiliación | University of KwaZulu-Natal. School of Laboratory Medicine & Medical Sciences. KwaZulu-Natal Research Innovation and Sequencing Platform. Durban, South Africa. | |
| Afiliación | University of KwaZulu-Natal. School of Laboratory Medicine & Medical Sciences. KwaZulu-Natal Research Innovation and Sequencing Platform. Durban, South Africa. | |
| Afiliación | University of KwaZulu-Natal. School of Laboratory Medicine & Medical Sciences. KwaZulu-Natal Research Innovation and Sequencing Platform. Durban, South Africa. | |
| Afiliación | University of KwaZulu-Natal. School of Laboratory Medicine & Medical Sciences. KwaZulu-Natal Research Innovation and Sequencing Platform. Durban, South Africa. | |
| Afiliación | University of KwaZulu-Natal. School of Chemistry and Physics. Quantum Research Group. Durban, South Africa / National Institute for Theoretical Physics. KwaZulu-Natal, South Africa. | |
| Afiliación | University of KwaZulu-Natal. School of Chemistry and Physics. Quantum Research Group. Durban, South Africa. | |
| Afiliación | University of Oxford. Department of Zoology. Oxford, United Kingdom. | |
| Afiliación | University of KwaZulu-Natal. School of Laboratory Medicine & Medical Sciences. KwaZulu-Natal Research Innovation and Sequencing Platform. Durban, South Africa. | |
| Afiliación | University of KwaZulu-Natal. School of Laboratory Medicine & Medical Sciences. KwaZulu-Natal Research Innovation and Sequencing Platform. Durban, South Africa / University of Oxford. Department of Zoology. Oxford, United Kingdom. | |
| Afiliación | University of Oxford. Department of Zoology. Oxford, United Kingdom. | |
| Afiliación | University of KwaZulu-Natal. School of Laboratory Medicine & Medical Sciences. KwaZulu-Natal Research Innovation and Sequencing Platform. Durban, South Africa. | |
| Afiliación | University of KwaZulu-Natal. School of Laboratory Medicine & Medical Sciences. KwaZulu-Natal Research Innovation and Sequencing Platform. Durban, South Africa. | |
| Afiliación | University of KwaZulu-Natal. School of Laboratory Medicine & Medical Sciences. KwaZulu-Natal Research Innovation and Sequencing Platform. Durban, South Africa. | |
| Afiliación | University of KwaZulu-Natal. School of Laboratory Medicine & Medical Sciences. KwaZulu-Natal Research Innovation and Sequencing Platform. Durban, South Africa. | |
| Afiliación | University of KwaZulu-Natal. School of Laboratory Medicine & Medical Sciences. KwaZulu-Natal Research Innovation and Sequencing Platform. Durban, South Africa / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | |
| Afiliación | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | |
| Afiliación | University of KwaZulu-Natal. School of Chemistry and Physics. Quantum Research Group. Durban, South Africa / National Institute for Theoretical Physics. KwaZulu-Natal, South Africa. | |
| Afiliación | University of KwaZulu-Natal. School of Laboratory Medicine & Medical Sciences. KwaZulu-Natal Research Innovation and Sequencing Platform. Durban, South Africa / Centre for the Aids Programme of Research in South Africa. Durban, South Africa / University of Washington. Department of Global Health. Seatle, WA, USA. | |
| Palavras clave en Inglês | SARS-CoV-2 | en_US |
| Palavras clave en Inglês | South Africa | en_US |
| Palavras clave en Inglês | NGS-SA | en_US |
| Palavras clave en Inglês | Next Generation Sequencing | en_US |
| Palavras clave en Inglês | Epidemiology | en_US |
| Palavras clave en Inglês | Phylogenetic | en_US |
| Palavras clave en Inglês | Transmission genomics | en_US |
| Palavras clave en Inglês | COVID-19 | en_US |
| e-ISSN | 1878-3511 |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
-
IOC - Artigos de Periódicos [12980]