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| Autor | Gupta, Gaurav | |
| Autor | Mou, Zhirong | |
| Autor | Jia, Ping | |
| Autor | Sharma, Rohit | |
| Autor | Zayats, Romaniya | |
| Autor | Viana, Sayonara M. | |
| Autor | Shan, Lianyu | |
| Autor | Barral, Aldina Maria Prado | |
| Autor | Oliveira, Viviane Sampaio Boaventura de | |
| Autor | Murooka, Thomas T. | |
| Autor | Gounni, Abdel Soussi | |
| Autor | Oliveira, Camila Indiani de | |
| Autor | Uzonna, ,Jude E. | |
| Fecha de acceso | 2021-02-11T13:47:19Z | |
| Fecha de disponibilización | 2021-02-11T13:47:19Z | |
| Fecha de publicación | 2020 | |
| Referencia | GUPTA, Gaurav et al. The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response. Cell Reports, 2020. | pt_BR |
| ISSN | 2211-1247 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/46042 | |
| Promoción | Canadian Institutes of Health Research (CIHR) and Research Manitoba. | pt_BR |
| Idioma | eng | pt_BR |
| Editor | Cell Press | pt_BR |
| Derechos de autor | open access | pt_BR |
| Palabras clave en Portugués | Leishmaniose cutânea | pt_BR |
| Palabras clave en Portugués | Pele | pt_BR |
| Palabras clave en Portugués | Infecções | pt_BR |
| Palabras clave en Portugués | Camundongos | pt_BR |
| Palabras clave en Portugués | Patogênese Homeopática | pt_BR |
| Título | The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response | pt_BR |
| Tipo del documento | Article | pt_BR |
| DOI | 10.1016/j.celrep.2020.108513 | |
| Resumen en Inglés | The long pentraxin 3 (PTX3) plays a critical role in inflammation, tissue repair, andwound healing.Here,weshow that PTX3 regulates disease pathogenesis in cutaneous leishmaniasis (CL). PTX3 expression increases in skin lesions in patients and mice during CL, with higher expression correlating with severe disease. PTX3-deficient (PTX3 / ) mice are highly resistant to L. major and L. braziliensis infections. This enhanced resistance is associated with increases in Th17 and IL-17A responses. The neutralization of IL-17A abolishes this enhanced resistance, while rPTX3 treatment results in decrease in Th17 and IL-17A responses and increases susceptibility. PTX3 / CD4+ T cells display increased differentiation to Th17 and expression of Th17-specific transcription factors. The addition of rPTX3 suppresses the expression of Th17 transcription factors, Th17 differentiation, and IL-17A production by CD4+ T cells from PTX3 / mice. Collectively, our results show that PTX3 contributes to the pathogenesis of CL by negatively regulating Th17 and IL-17A responses. | pt_BR |
| Afiliación | University of Manitoba. Rady Faculty of Health Sciences. Max Rady College of Medicine. Department of Immunology. Winnipeg, MB, Canada / NIIT University. Rajasthan, India. | pt_BR |
| Afiliación | University of Manitoba. Rady Faculty of Health Sciences. Max Rady College of Medicine. Department of Immunology. Winnipeg, MB, Canada. | pt_BR |
| Afiliación | University of Manitoba. Rady Faculty of Health Sciences. Max Rady College of Medicine. Department of Immunology. Winnipeg, MB, Canada. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz, Instituto de Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Afiliación | University of Manitoba. Rady Faculty of Health Sciences. Max Rady College of Medicine. Department of Immunology. Winnipeg, MB, Canada. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz, Instituto de Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Afiliación | University of Manitoba. Rady Faculty of Health Sciences. Max Rady College of Medicine. Department of Immunology. Winnipeg, MB, Canada. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz, Instituto de Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz, Instituto de Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Afiliación | University of Manitoba. Rady Faculty of Health Sciences. Max Rady College of Medicine. Department of Immunology. Winnipeg, MB, Canada. | pt_BR |
| Afiliación | University of Manitoba. Rady Faculty of Health Sciences. Max Rady College of Medicine. Department of Immunology. Winnipeg, MB, Canada. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz, Instituto de Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Afiliación | University of Manitoba. Rady Faculty of Health Sciences. Max Rady College of Medicine. Department of Immunology. Winnipeg, MB, Canada. | pt_BR |
| Palavras clave en Inglês | Cutaneous Leishmaniasis | pt_BR |
| Palavras clave en Inglês | Skin | pt_BR |
| Palavras clave en Inglês | Infections | pt_BR |
| Palavras clave en Inglês | Mice | pt_BR |
| Palavras clave en Inglês | Pathogenesis, Homeopathic | pt_BR |
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