| Author | Cunha Júnior, Ademar Dantas da | |
| Author | Zanette, Dalila Lucíola | |
| Author | Pericole, Fernando Vieira | |
| Author | Saad, Sara Teresinha Olalla | |
| Author | Carvalheira, José Barreto Campello | |
| Access date | 2021-02-18T23:21:02Z | |
| Available date | 2021-02-18T23:21:02Z | |
| Document date | 2021 | |
| Citation | CUNHA JÚNIOR, Ademar Dantas da et al. Obesity as a possible risk factor for progression from monoclonal gammopathy of undetermined significance progression into multiple myeloma: could myeloma be prevented with metformin treatment? Advances in Hematology, p. 1-7, 2021. | pt_BR |
| ISSN | 1687-9112 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/46103 | |
| Language | por | pt_BR |
| Publisher | Hindawi | pt_BR |
| Rights | open access | pt_BR |
| Title | Obesity as a possible risk factor for progression from monoclonal gammopathy of undetermined significance progression into multiple myeloma: could myeloma be prevented with metformin treatment? | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1155/2021/6615684 | pt_BR |
| Abstract | Obesity is increasingly associated with the transformation of monoclonal gammopathy of undetermined significance (MGUS) into multiple myeloma (MM). Obesity, MGUS, and MM share common etiopathogenesis mechanisms including altered insulin axis and the action of inflammatory cytokines. Consistent with this interconnection, metformin could predominantly exert inhibition of these pathophysiological factors and thus be an attractive therapeutic option for MGUS. Despite the possible clinical significance, only a limited number of epidemiological studies have focused on obesity as a risk factor for MGUS and MM. (is review describes multiple biological pathways modulated by metformin at the cellular level and their possible impacts on the
biology of MGUS and its progression into MM. | pt_BR |
| Affilliation | Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Medicina Interna. Divisão de Oncologia. Campinas, SP, Brasil / Hospital de Câncer de Cascavel. União Oeste Paranaense de Estudos e Combate ao Câncer. Clínica de Oncologia e Hematologia. Cascavel, PR. Brasil / Universidade Estadual do Oeste do Paraná. Departamento de Medicina Interna. Cascavel, PR. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade de Campinas. Centro de Hematologia e Hemoterapia. Campinas, SP, Brasil. | pt_BR |
| Affilliation | Universidade de Campinas. Centro de Hematologia e Hemoterapia. Campinas, SP, Brasil. | pt_BR |
| Affilliation | Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Medicina Interna. Divisão de Oncologia. Campinas, SP, Brasil. | pt_BR |
| Subject | Multiple Myeloma | pt_BR |
| Subject | Monoclonal Gammopathy of Undetermined Significance | pt_BR |
| Subject | Obesity | pt_BR |
| Subject | Metformin | pt_BR |
| Subject | Pharmaceutical Preparations | pt_BR |
| Subject in Spanish | Mieloma Múltiple | pt_BR |
| Subject in Spanish | Gammopatía Monoclonal de Relevancia Indeterminada | pt_BR |
| Subject in Spanish | Obesidad | pt_BR |
| Subject in Spanish | Metformina | pt_BR |
| Subject in Spanish | Preparaciones Farmacéuticas | pt_BR |
| Subject in French | Myélome multiple | pt_BR |
| Subject in French | Gammapathie monoclonale de signification indéterminée | pt_BR |
| Subject in French | Obésité | pt_BR |
| Subject in French | Metformine | pt_BR |
| Subject in French | Préparations pharmaceutiques | pt_BR |
| DeCS | Mieloma Múltiplo | pt_BR |
| DeCS | Gamopatia Monoclonal de Significância Indeterminada | pt_BR |
| DeCS | Obesidade | pt_BR |
| DeCS | Metformina | pt_BR |
| DeCS | Preparações Farmacêuticas | pt_BR |
