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AutorVinhaes, Caian L.
AutorPereira, Mariana Araujo
AutorTibúrcio, Rafael
AutorCubillos-Angulo, Juan Manuel
AutorDemitto, Fernanda O.
AutorAkrami, Kevan M.
AutorAndrade, Bruno de Bezerril
Fecha de acceso2021-03-04T12:03:06Z
Fecha de disponibilización2021-03-04T12:03:06Z
Fecha de publicación2021
ReferenciaVINHAES, Caian L. et al. Systemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome in Persons Living with HIV. Life, v. 11, 2021.pt_BR
ISSN2075-1729pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/46252
PromociónIntramural Research Program of the Fundação Oswaldo Cruz, Brazil. The work of Caian Vinhes was supported by MONSTER Initiative and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. Mariana Araújo-Pereira, Rafael Tibúrcio and Juan Cubillos-Angulo were supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (PhD fellowship. Finance code 001). Bruno Andrade is a senior fellow from CNPq and was also supported by the National Institutes of Allergy and Infectious Diseases, USA (U01-AI115940).pt_BR
Idiomaengpt_BR
EditorMDPIpt_BR
Derechos de autoropen accesspt_BR
Palabras clave en PortuguésInflamaçãopt_BR
Palabras clave en PortuguésMortalidadept_BR
Palabras clave en PortuguésHIVpt_BR
Palabras clave en PortuguésSíndrome Inflamatória da Reconstituição Imunept_BR
TítuloSystemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome in Persons Living with HIVpt_BR
Tipo del documentoArticlept_BR
DOI10.3390/life11010065
Resumen en InglésAntiretroviral therapy (ART) has represented a major advancement in the care of people living with HIV (PLWHH), resulting in significant reductions in morbidity and mortality through immune reconstitution and attenuation of homeostatic disruption. Importantly, restoration of immune function in PLWH with opportunistic infections occasionally leads to an intense and uncontrolled cytokine storm following ART initiation known as immune reconstitution inflammatory syndrome (IRIS). IRIS occurrence is associated with the severe and rapid clinical deterioration that results in significant morbidity and mortality. Here, we detail the determinants underlying IRIS development in PLWH, compiling the available knowledge in the field to highlight details of the inflammatory responses in IRIS associated with the most commonly reported opportunistic pathogens. This review also highlights gaps in the understanding of IRIS pathogenesis and summarizes therapeutic strategies that have been used for IRIS.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Bahia Foundation for the Development of Sciences. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil.pt_BR
AfiliaciónMultinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil .pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil / University of California. Department of Medicine. Divisions of Infectious Diseases and Pulmonary, Critical Care and Sleep Medicine. San Diego, CA, USA.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Bahia Foundation for the Development of Sciences. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil / Centro Universitário Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brazil.pt_BR
Palavras clave en InglêsSystemic inflammationpt_BR
Palavras clave en InglêsMycobacteriapt_BR
Palavras clave en InglêsHIVpt_BR
Palavras clave en InglêsImmune reconstitution inflammatory syndrome (IRIS)pt_BR
xmlui.metadata.dc.subject.ods03 Saúde e Bem-Estar


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