| Author | Kurtz, Pedro | |
| Author | Righy, Cassia | |
| Author | Gadelha, Monica | |
| Author | Bozza, Fernando A. | |
| Author | Bozza, Patrícia T. | |
| Author | Gonçalves, Bruno | |
| Author | Bastos, Leonardo S. L. | |
| Author | Vale, Andre M. | |
| Author | Higa, Luiza M. | |
| Author | Castilho, Leda | |
| Author | Monteiro, Fabio L. | |
| Author | Charris, Nestor | |
| Author | Fialho, Fernanda | |
| Author | Turon, Ricardo | |
| Author | Gueterrez, Alexandro | |
| Author | Miranda, Rena Lyra | |
| Author | Lima, Carlos Henrique de Azeredo | |
| Author | Caro, Vanessa de | |
| Author | Prazeres, Marco Aurelio | |
| Author | Ventura, Nina | |
| Author | Gaspari, Clara | |
| Author | Miranda, Fabio | |
| Author | Mata, Paulo José da | |
| Author | Pêcego, Margarida | |
| Author | Mateos Sheila, Sheila | |
| Author | Lopes, Maria Esther | |
| Author | Casrilho, Shirley | |
| Author | Oliveira, Álvaro | |
| Author | Bioquimpani, Carla | |
| Author | Rabello, Andrea | |
| Author | Lopes, Josiane | |
| Author | Conceição Neto, Orlando | |
| Author | Ferreira Jr., Orlando da C. | |
| Author | Tanuri, Amilcar | |
| Author | Niemeyer Filho, Paulo | |
| Author | Amorim, Luiz | |
| Access date | 2021-03-09T14:54:19Z | |
| Available date | 2021-03-09T14:54:19Z | |
| Document date | 2021 | |
| Citation | KURTZ, Pedro et al. Effect of Convalescent Plasma in Critically Ill Patients With COVID-19: An Observational Study. Frontiers in Medicine, v. 8, Article 630982, p. 1-9, Jan. 2021. | pt_BR |
| ISSN | 2296-858X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/46314 | |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Plasma convalescente | pt_BR |
| Subject in Portuguese | Coronavírus | pt_BR |
| Subject in Portuguese | Síndrome do desconforto respiratório agudo | pt_BR |
| Subject in Portuguese | COVID-19 | pt_BR |
| Subject in Portuguese | Sobrevivência | pt_BR |
| Title | Effect of Convalescent Plasma in Critically Ill Patients With COVID-19: An Observational Study | pt_BR |
| Type | Article | |
| DOI | 10.3389/fmed.2021.630982 | |
| Abstract | Background: Convalescent plasma is a potential therapeutic option for critically ill patients with coronavirus disease 19 (COVID-19), yet its efficacy remains to be determined. The aim was to investigate the effects of convalescent plasma (CP) in critically ill patients with COVID-19. Methods: This was a single-center prospective observational study conducted in Rio de Janeiro, Brazil, from March 17th to May 30th, with final follow-up on June 30th. We included 113 laboratory-confirmed COVID-19 patients with respiratory failure. Primary outcomes were time to clinical improvement and survival within 28 days. Secondary outcomes included behavior of biomarkers and viral loads. Kaplan–Meier analyses and Cox proportional-hazards regression using propensity score with inverse-probability weighing were performed. Results: 41 patients received CP and 72 received standard of care (SOC). Median age was 61 years (IQR 48–68), disease duration was 10 days (IQR 6–13), and 86% were mechanically ventilated. At least 29 out of 41CP-recipients had baseline IgG titers ≥ 1:1,080. Clinical improvement within 28 days occurred in 19 (46%) CP-treated patients, as compared to 23 (32%) in the SOC group [adjusted hazard ratio (aHR) 0.91 (0.49–1.69)]. There was no significant change in 28-day mortality (CP 49% vs. SOC 56%; aHR 0.90 [0.52–1.57]). Biomarker assessment revealed reduced inflammatory activity and increased lymphocyte count after CP. Conclusions: In this study, CP was not associated with clinical improvement or increase in 28-day survival. However, our study may have been underpowered and included patients with high IgG titers and life-threatening disease. Clinical Trial Registration: The study protocol was retrospectively registered at the Brazilian Registry of Clinical Trials (ReBEC) with the identification RBR-4vm3yy (http:// www.ensaiosclinicos.gov.br). | pt_BR |
| Affilliation | Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto D`Or de Educação e Pesquisa. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacollgia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Pontifícia Universidade Católica do Rio de Janeiro. Departamento de Engenharia Industrial. Rio de Janeiro,. RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Biologia de Linfócitos. Programa de Imunobiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. COPPE. Programa de Engenharia Química. Laboratório de Engenharia de Cultura Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Convalescent plasma | pt_BR |
| Subject | Coronavirus | pt_BR |
| Subject | Acute respiratory distress syndrome | pt_BR |
| Subject | COVID-19 | pt_BR |
| Subject | Survival | pt_BR |
