Author | Barisón, María Julia | |
Author | Pereira, Isabela Tiemy | |
Author | Robert, Anny Waloski | |
Author | Dallagiovanna, Bruno | |
Access date | 2021-03-15T15:18:04Z | |
Available date | 2021-03-15T15:18:04Z | |
Document date | 2021 | |
Citation | Barisón, Maria Julia et al. Reorganization of metabolism during cardiomyogenesis implies time-specific signaling pathway regulation. Int. J. Mol. Sci., v. 22, n.1330, p. 1-27, 2021.Barisón, Maria Julia et al. Reorganization of metabolism during cardiomyogenesis implies time-specific signaling pathway regulation. Int. J. Mol. Sci., v. 22, n.1330, p. 1-27, 2021. | pt_BR |
ISSN | 1422-0067 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/46362 | |
Language | por | pt_BR |
Publisher | MDPI | pt_BR |
Rights | open access | pt_BR |
Title | Reorganization of metabolism during cardiomyogenesis implies time-specific signaling pathway regulation | pt_BR |
Type | Article | pt_BR |
DOI | https://doi.org/10.3390/ ijms22031330 | |
Abstract | Understanding the cell differentiation process involves the characterization of signaling and regulatory pathways. The coordinated action involved in multilevel regulation determines the commitment of stem cells and their differentiation into a specific cell lineage. Cellular metabolism plays a relevant role in modulating the expression of genes, which act as sensors of the extra-and intracellular environment. In this work, we analyzed mRNAs associated with polysomes by focusing on the expression profile of metabolism-related genes during the cardiac differentiation of human embryonic stem cells (hESCs). We compared different time points during cardiac differentiation (pluripotency, embryoid body aggregation, cardiac mesoderm, cardiac progenitor and cardiomyocyte) and showed the immature cell profile of energy metabolism. Highly regulated canonical pathways are thoroughly discussed, such as those involved in metabolic signaling and lipid homeostasis. We reveal the critical relevance of retinoic X receptor (RXR) heterodimers in upstream retinoic acid metabolism and their relationship with thyroid hormone signaling. Additionally, we highlight the importance of lipid homeostasis and extracellular matrix component biosynthesis during cardiomyogenesis, providing new insights into how hESCs reorganize their metabolism during in vitro cardiac differentiation. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil. | pt_BR |
Subject | Cell Differentiation | pt_BR |
Subject | Myocytes, Cardiac | pt_BR |
Subject | Metabolism | pt_BR |
Subject | Homeostasis | pt_BR |
Subject | Human Embryonic Stem Cells | pt_BR |
Subject in Spanish | Diferenciación Celular | pt_BR |
Subject in Spanish | Miocitos Cardíacos | pt_BR |
Subject in Spanish | Células Madre Embrionarias Humanas | pt_BR |
Subject in French | Différenciation cellulaire | pt_BR |
Subject in French | Myocytes cardiaques | pt_BR |
Subject in French | Métabolisme | pt_BR |
Subject in French | Homéostasie | pt_BR |
Subject in French | Cellules souches embryonnaires humaines | pt_BR |
DeCS | Diferenciação Celular | pt_BR |
DeCS | Miócitos Cardíacos | pt_BR |
DeCS | Metabolismo | pt_BR |
DeCS | Homeostase | pt_BR |
DeCS | Células-Tronco Embrionárias Humanas | pt_BR |