| Author | Borges, Juliana Pereira | |
| Author | Mendes, Fernanda de Souza Nogueira Sardinha | |
| Author | Rangel, Marcus Vinícius dos Santos | |
| Author | Lopes, Gabriella de Oliveira | |
| Author | Silva, Gilberto Marcelo Sperandio da | |
| Author | Silva, Paula Simplício da | |
| Author | Mazzoli-Rocha, Flavia | |
| Author | Saraiva, Roberto Magalhães | |
| Author | Sousa, Andrea Silvestre de | |
| Author | Tibirica, Eduardo | |
| Author | Mediano, Mauro Felippe Felix | |
| Access date | 2021-03-15T17:31:59Z | |
| Available date | 2021-03-15T17:31:59Z | |
| Document date | 2021 | |
| Citation | BORGES, Juliana Pereira et al. Exercise training improves microvascular function in patients with Chagas heart disease: Data from the PEACH study. Microvascular research, v. 134, p. 1-4, 2021 | pt_BR |
| ISSN | 0026-2862 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/46364 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Exercise training improves microvascular function in patients with Chagas heart disease: Data from the PEACH study | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.mvr.2020.104106 | |
| Abstract | Background: Chagas heart disease (CHD) impairs the systemic microvascular function. We investigated the effects of exercise training on cutaneous microvascular function among patients with CHD.
Methods: Patients from the PEACH study were randomly assigned to a supervised exercise training 3 times/week for 6 months (Trained; n = 10) or a control group (Untrained; n = 8). Both groups underwent evaluation of microvascular function before, and at 3- and 6-months of follow-up. Cutaneous vascular conductance (CVC) was assessed in the skin of the forearm using laser speckle contrast imaging coupled with iontophoresis of acetylcholine (ACh), sodium nitroprusside (SNP) and during post-occlusive reactive hyperemia (PORH).
Results: At 3-months of follow-up, no difference was detected between groups in CVC responses to ACh (p = 0.50), SNP (p = 0.26) and HRPO (p = 0.65). However, at 6-months of follow-up, trained vs. untrained patients improved CVC induced by SNP-iontophoresis (0.19 ± 0.10 vs. 0.14 ± 0.15 APU.mmHg-1; p = 0.05) and PORH (0.63 ± 0.15 vs. 0.48 ± 0.18 APU.mmHg-1; p = 0.05). CVC response to ACh-iontophoresis was similar between groups (0.19 ± 0.11 vs. 0.22 ± 0.17 APU.mmHg-1; p = 0.38).
Conclusion: Exercise training performed during 6 months improved the cutaneous microvascular function of CHD patients. Further studies evaluating the mechanism involved in this response are warranted. | pt_BR |
| Affilliation | University of Rio de Janeiro State. Laboratory of Physical Activity and Health Promotion. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of Rio de Janeiro State. Laboratory of Physical Activity and Health Promotion. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | University of Rio de Janeiro State. Laboratory of Physical Activity and Health Promotion. Rio de Janeiro, RJ, Brazil / Ministry of Health. National Institute of Cardiology. Department of Research and Education. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Ministry of Health. National Institute of Cardiology. Department of Research and Education. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Ministry of Health. National Institute of Cardiology. Department of Research and Education. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Subject | Cardiac rehabilitation | pt_BR |
| Subject | Chagas heart disease | pt_BR |
| Subject | Cutaneous vascular conductance | pt_BR |
| Subject | Endothelial function | pt_BR |
| Subject | Microvascular flowmetry | pt_BR |
