| Author | Almeida, Ray Silva de | |
| Author | Araújo, Ana Carolina Justino de | |
| Author | Freitas, Priscilla Ramos | |
| Author | Ferreira, Vitória Assunção | |
| Author | Leite, Pedro Ivo Palacio | |
| Author | Tintino, Saulo Relison | |
| Author | Tintino, Cicera Datiane de Morais Oliveira | |
| Author | Coutinho, Henrique Douglas Melo | |
| Author | Ribeiro Filho, Jaime | |
| Author | Costa, Raíra Justino Oliveira | |
| Access date | 2021-03-19T14:40:34Z | |
| Available date | 2021-03-19T14:40:34Z | |
| Document date | 2021 | |
| Citation | ALMEIDA, Ray Silva de at al. Antibactarial and larvicide activity of the ethanolic extract of Azadirachta indica. Juss (Meliaceae). Revista Interfaces,v. 9, n. 1, 2021. | pt_BR |
| ISSN | 2317-434X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/46381 | |
| Description | Ribeiro Filho, Jaime. “Documento protegido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
| Sponsorship | Regional University of Cariri and the Laboratory of Microbiology and Molecular Biology | pt_BR |
| Language | eng | pt_BR |
| Publisher | Desconhecido | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Aedes aegypti | pt_BR |
| Subject in Portuguese | Azadirachta | pt_BR |
| Subject in Portuguese | Resistência bacteriana | pt_BR |
| Subject in Portuguese | Atividade larvicida | pt_BR |
| Title | Antibactarial and larvicide activity of the ethanolic extract of Azadirachta indica. Juss (Meliaceae) | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.16891/2317 434X.v9.e1.a2021.pp823 832 | |
| Abstract | Azadirachta indica, popularly known as "Indian neem" is a species widely used in folk medicine due to its antimicrobial properties. The present study aimed to evaluate the antimicrobial properties and analyze the cytotoxicity of the ethanolic extract of the Azadirachta indica plant (AiEE) against larvae of the Aedes aegypti mosquito. A preliminary phytochemical analysis by Thin-Layer Chromatography was used to determine the presence of secondary metabolites. The larvicidal activity was evaluated at 30 min, 1h, 2h, 4h, 8h, 16h and 24h, observing the larval mortality before different extract concentrations. The antibacterial activity of the extract against multiresistant strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa in the presence or absence of antibiotics was analyzed using the broth microdilution method. The qualitative phytochemical analysis revealed the presence of coumarins, phenols, terpenes and triterpenes. AiEE displayed a concentration-dependent larvicidal activity although no clinically relevant antibacterial activity was observed, the extract potentiated the activity of conventional antibiotics. Our results suggest that AiEE has bioactive constituents with the potential to be explored in research aimed at combating dengue and antibiotic resistance. | pt_BR |
| Affilliation | Universidade Regional do Cariri. Crato, CE, Brasil. | pt_BR |
| Affilliation | Universidade Regional do Cariri. Crato, CE, Brasil. | pt_BR |
| Affilliation | Universidade Regional do Cariri. Crato, CE, Brasil. | pt_BR |
| Affilliation | Universidade Regional do Cariri. Crato, CE, Brasil. | pt_BR |
| Affilliation | Universidade Regional do Cariri. Crato, CE, Brasil. | pt_BR |
| Affilliation | Universidade Regional do Cariri. Crato, CE, Brasil. | pt_BR |
| Affilliation | Universidade Regional do Cariri. Crato, CE, Brasil. | pt_BR |
| Affilliation | Universidade Regional do Cariri. Crato, CE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil. | pt_BR |
| Affilliation | Universidade Regional do Cariri. Crato, CE, Brasil. | pt_BR |
| Subject | Aedes aegypti | pt_BR |
| Subject | Azadirachta indica | pt_BR |
| Subject | Bacterial resistance | pt_BR |
| Subject | Larvicidal activity | pt_BR |
