| Author | Costa, Federico | |
| Author | Zeppelini, Caio Graco | |
| Author | Ribeiro, Guilherme de Sousa | |
| Author | Santos, Norlan | |
| Author | Reis, Renato Barbosa | |
| Author | Martins, Ridalva D. | |
| Author | Bittencourt, Deborah | |
| Author | Santana, Carlos | |
| Author | Brant, Jonas | |
| Author | Reis, Mitermayer Galvão dos | |
| Author | Ko, Albert Icksang | |
| Access date | 2021-04-05T13:57:06Z | |
| Available date | 2021-04-05T13:57:06Z | |
| Document date | 2021 | |
| Citation | COSTA, Federico et al. Household rat infestation in urban slum populations: Development and validation of a predictive score for leptospirosis. PLOS Neglected Tropical Diseases, p. 1-13, Mar. 3, 2021. | pt_BR |
| ISSN | 1935-2735 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/46505 | |
| Sponsorship | National Institutes of Health
(grants R01 AI052473, U01 AI088752, R01
TW009504, R24 TW007988, R25 TW009338 and
D43 TW00919). FC has been granted funds by the
Wellcome trust for the study [102330/Z/13/Z;
218987/Z/19/Z] and a CAPES doctorate
scholarship (Coordination for the Improvement of
Higher Education Personnel/ Ministry of Education/
Brazil; https://www.gov.br/capes/pt-br), CGZ has
received a doctorate scholarship from FAPESB
(Foundation for Research Assistance of Bahia,
http://www.fapesb.ba.gov.br/). GSR received a
research scholarship from the Brazilian National
Research Council (CNPq – www.cnpq.br). The
funders had no role in study design, data collection
and analysis, decision to publish or preparation of
the manuscript. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Leptospirose | pt_BR |
| Subject in Portuguese | População | pt_BR |
| Subject in Portuguese | Áreas de Pobreza | pt_BR |
| Subject in Portuguese | Fatores de risco | pt_BR |
| Subject in Portuguese | Características da Família | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | Household rat infestation in urban slum populations: development and validation of a predictive score for leptospirosis | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1371/journal.pntd.0009154 | pt_BR |
| Abstract | Domestic rats are the principal reservoir for urban leptospirosis. However, few studies have identified infestation markers in slums and evaluated their predictivity for leptospirosis risk. We compared households with leptospirosis cases in Salvador, Brazil between 2007 and 2009 and their neighbors using a case control design, surveying for rodent infestation signs and environmental characteristics. With the 2007–2008 data, a conditional logistic regression modeling identified the peridomiciliar presence of rodent burrows (OR, 3.30; 95% CI, 1.50–7.26), rat feces (2.86; 1.24–6.59), runs (2.57; 1.06–6.22), households bordering abandoned houses (2.48; 1.04–6.02), and unplastered walls (2.22; 1.02–6.02) as risk factors and developed a predictive score for leptospirosis. With an independent data set from 2009, a receiver operating characteristic (ROC) curve analysis evaluated the prediction score performance, with the area under the curve being 0.70 (95% CI, 0.64–0.76) for score development and 0.71 (0.65–0.79) for validation. Results indicate that high proportions of urban slum households are infested with R. norvegicus. The score performed well when identifying high-risk households within slums. These findings need confirmation in other urban centers, but suggest that community-based screening for rodent infestation can allow to target rodent and environmental control measures in populations at highest risk for leptospirosis. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Universidade Federal da Bahia. Programa de Pós-Graduação em Ecologia: Teoria, Aplicação e Valores. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Programa de Pós-Graduação em Ecologia: Teoria, Aplicação e Valores. Salvador, BA, Brasil / Universidade Federal da Paraíba. Laboratório de Mamíferos. João Pessoa, PB, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Ministério da Saúde. Centro de Controle de Zoonoses. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Ministério da Saúde. Secretaria de Vigilância em Saúde. Programa de Treinamento em Epidemiologia Aplicada aos Serviços do SUS. Brasıília, DF, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale University, New Heaven. Yale School of Public Health. USA. | pt_BR |
| Subject | Leptospirosis | pt_BR |
| Subject | Population | pt_BR |
| Subject | Poverty Areas | pt_BR |
| Subject | Risks factors | pt_BR |
| Subject | Family Characteristics | pt_BR |
| Subject | Brazil | pt_BR |
| e-ISSN | 10.1371/journal.pntd.0009154 | |
| xmlui.metadata.dc.subject.ods | 01 Erradicação da pobreza | |
