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AutorKern, Rei Chng
AutorChenhao, Li
AutorBertrand, Denis
AutorNg, Amanda Hui Qi
AutorKwah, Junmei Samantha
AutorHwee, Meng Low
AutorChengxuan, Tong
AutorNatrajan, Maanasa
AutorZhang, Michael Hongjie
AutorLicheng, Xu
AutorKarrie, Kwan Ki Ko
AutorHo, Eliza Xin Pei
AutorAv-Shalom, Tamar V.
AutorTeo, Jeanette Woon Pei
AutorKhor, Chiea Chuen
AutorChen, Swaine L.
AutorMason, Christopher E.
AutorNg, Oon Tek
AutorMarimuthu, Kalisvar
AutorAng, Brenda
AutorNagarajan, Niranjan
AutorMetaSUB Consortium
Fecha de acceso2021-04-08T18:47:26Z
Fecha de disponibilización2021-04-08T18:47:26Z
Fecha de publicación2020
ReferenciaCHNG, Kernr Rei et al. Cartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environment. Nature Medicine, v. 26, p. 941-951, June 2020.pt_BR
ISSN1078-8956pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/46582
DescripciónMilton Osório Moraes - Fundação Oswaldo Cruz Laboratório de Hanseníase, Rio de Janeiro, RJ, Brasil. MetaSUB Consortium.pt_BR
DescripciónAfiliação: Autores: 1Computational and Systems Biology, Genome Institute of Singapore, Singapore, Singapore. 2Information Systems Technology and Design, Singapore University of Technology and Design, Singapore, Singapore. 3Department of Microbiology, Singapore General Hospital, Singapore, Singapore. 4Department of Molecular Pathology, Singapore General Hospital, Singapore, Singapore. 5Duke-NUS Graduate Medical School, Singapore, Singapore. 6Department of Laboratory Medicine, National University Hospital, Singapore, Singapore. 7Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA. 8National Centre for Infectious Diseases, Singapore, Singapore. 9Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore. 10Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. 11Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. 60These authors contributed equally: Kern Rei Chng, Chenhao Li, Denis Bertrand. *A full list of authors and their affiliations appears at the end of the paper. ✉e-mail: nagarajann@gis.a-star.edu.sgpt_BR
DescripciónAutores MetaSUB Consortium: David Danko12,13, Daniela Bezdan12,13, Ebrahim Afshinnekoo12,13, Sofia Ahsanuddin14, Chandrima Bhattacharya12,13, Daniel J. Butler12,13, Kern Rei Chng15, Francesca De Filippis16, Jochen Hecht17, Andre Kahles18, Mikhail Karasikov18, Nikos C. Kyrpides19, Marcus H. Y. Leung20, Dmitry Meleshko12,13, Harun Mustafa18, Beth Mutai17,21, Russell Y. Neches19, Amanda Ng15, Marina Nieto-Caballero22, Olga Nikolayeva18, Tatyana Nikolayeva18, Eileen Png15, Jorge L. Sanchez12, Heba Shaaban12,13, Maria A. Sierra12,13, Xinzhao Tong20, Ben Young12,13, Josue Alicea12,13, Malay Bhattacharyya23, Ran Blekhman24, Eduardo Castro-Nallar25, Ana M. Cañas12, Aspassia D. Chatziefthimiou26, Robert W. Crawford27, Youping Deng28, Christelle Desnues29, Emmanuel Dias-Neto30, Daisy Donnellan12, Marius Dybwad31, Eran Elhaik32, Danilo Ercolini16, Alina Frolova33, Alexandra B. Graf34, David C. Green35, Iman Hajirasouliha12,13, Mark Hernandez22, Gregorio Iraola36, Soojin Jang37, Angela Jones38, Frank J. Kelly35, Kaymisha Knights12, Paweł P. Łabaj39, Patrick K. H. Lee20, Levy Shawn40, Per Ljungdahl41, Abigail Lyons12, Gabriella Mason-Buck35, Ken McGrath42, Emmanuel F. Mongodin43, Milton Ozorio Moraes44, Niranjan Nagarajan15, Houtan Noushmehr45, Manuela Oliveira46, Stephan Ossowski47, Olayinka O. Osuolale48, Orhan Özcan49, David Paez-Espino19, Nicolas Rascovan29, Hugues Richard50, Gunnar Rätsch18, Lynn M. Schriml43, Torsten Semmler51, Osman U. Sezerman49, Leming Shi52, Le Huu Song53, Haruo Suzuki54, Denise Syndercombe Court35, Dominique Thomas12, Scott W. Tighe55, Klas I. Udekwu41, Juan A. Ugalde56, Brandon Valentine12, Dimitar I. Vassilev57, Elena Vayndorf58, Thirumalaisamy P. Velavan59, María M. Zambrano38, Jifeng Zhu12, Sibo Zhu52 and Christopher E. Mason12,13.pt_BR
DescripciónAfiliação MetaSUB Consortium: 12Weill Cornell Medicine, New York, NY, USA. 13The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY, USA. 14Icahn School of Medicine at Mount Sinai, New York, NY, USA. 15Genome Institute of Singapore, Singapore, Singapore. 16University of Naples Federico II, Naples, Italy. 17The Barcelona Institute of Science and Technology, Barcelona, Spain. 18ETH Zurich, Zurich, Switzerland. 19Joint Genome Institute, Walnut Creek, CA, USA. 20City University of Hong Kong, Hong Kong SAR, China. 21Kenya Medical Research Institute/Medical Research Directorate-Africa, Kisumu, Kenya. 22University of Colorado Boulder, Boulder, CO, USA. 23Indian Statistical Institute, Kolkata, India. 24University of Minnesota, Minneapolis, MN, USA. 25Universidad Andrés Bello, Santiago, Chile. 26Weill Cornell Medicine—Qatar, Doha, Qatar. 27California State University Sacramento, Sacramento, CA, USA. 28University of Hawaii, Honolulu, HI, USA. 29Aix-Marseille Université, Marseille, France. 30A.C.Camargo Cancer Center, São Paulo, Brazil. 31Norwegian Defence Research Establishment, Kjeller, Norway. 32University of Sheffield, Sheffield, UK. 33Institute of Molecular Biology and Genetics of National Academy of Sciences of Ukraine, Kyiv, Ukraine. 34University of Applied Sciences FH-Campus Wien, Vienna, Austria. 35King’s College London, London, UK. 36Institut Pasteur de Montevideo, Montevideo, Uruguay. 37Institut Pasteur Korea, Seongnam, South Korea. 38Corporación Corpogen, Bogotá, Colombia. 39Jagiellonian University, Kraków, Poland. 40HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA. 41Stockholm University, Stockholm, Sweden. 42Microba, Brisbane, Australia. 43University of Maryland School of Medicine, Baltimore, MD, USA. 44Fundação Oswaldo Cruz Laboratório de Hanseníase, Rio de Janeiro, Brazil. 45Ribeirão Preto Medical School University of São Paulo, São Paulo, Brazil. 46Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal. 47University of Tübingen, Tübingen, Germany. 48Elizade University, Ondo State, Nigeria. 49Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey. 50Sorbonne University, Paris, France. 51Robert Koch Institute, Berlin, Germany. 52Fudan University, Shanghai, China. 53Vietnamese-German Center of Excellence, Hanoi, Vietnam. 54Keio University, Fujisawa, Japan. 55University of Vermont, Burlington, VT, USA. 56Millennium Initiative for Collaborative Research on Bacterial Resistance, Santiago, Chile. 57Sofia University, Sofia, Bulgaria. 58University of Alaska Fairbanks, Fairbanks, AK, USA. 59Univeristätsklinikum Tübingen, Tübingen, Germany.pt_BR
Idiomaengpt_BR
EditorNaturept_BR
Derechos de autoropen access
Palabras clave en PortuguésPatógenos oportunistaspt_BR
Palabras clave en Portuguéscartografiapt_BR
Palabras clave en PortuguésResistência a antibióticospt_BR
Palabras clave en PortuguésGenespt_BR
Palabras clave en PortuguésAmbiente hospitalar terciáriopt_BR
TítuloCartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environmentpt_BR
Tipo del documentoArticle
DOI10.1038/s41591-020-0894-4
Resumen en InglésAlthough disinfection is key to infection control, the colonization patterns and resistomes of hospital-environment microbes remain underexplored. We report the first extensive genomic characterization of microbiomes, pathogens and antibiotic resistance cassettes in a tertiary-care hospital, from repeated sampling (up to 1.5 years apart) of 179 sites associated with 45 beds. Deep shotgun metagenomics unveiled distinct ecological niches of microbes and antibiotic resistance genes characterized by biofilm-forming and human-microbiome-influenced environments with corresponding patterns of spatiotemporal divergence. Quasi-metagenomics with nanopore sequencing provided thousands of high-contiguity genomes, phage and plasmid sequences (>60% novel), enabling characterization of resistome and mobilome diversity and dynamic architectures in hospital environments. Phylogenetics identified multidrug-resistant strains as being widely distributed and stably colonizing across sites. Comparisons with clinical isolates indicated that such microbes can persist in hospitals for extended periods (>8 years), to opportunistically infect patients. These findings highlight the importance of characterizing antibiotic resistance reservoirs in hospitals and establish the feasibility of systematic surveys to target resources for preventing infections.pt_BR
AfiliaciónMúltipla autoria - ver em Notas.pt_BR
Palavras clave en InglêsCartographypt_BR
Palavras clave en InglêsOpportunistic pathogenspt_BR
Palavras clave en InglêsAntibiotic resistancept_BR
Palavras clave en InglêsGenespt_BR
Palavras clave en InglêsTertiary hospital environmentpt_BR


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