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| Autor | Barros, Tamiris Azamor da Costa | |
| Autor | Cunha, Daniela Prado | |
| Autor | Silva, Andréa Marques Vieira da | |
| Autor | Alves, Marcelo Ribeiro | |
| Autor | Bezerra, Ohanna Cavalcanti de Lima | |
| Autor | Kehdy, Fernanda de Souza Gomes | |
| Autor | Ano Bom, Ana Paula Dinis | |
| Autor | Neves, Patrícia Cristina da Costa | |
| Autor | Vasconcelos, Zilton Farias Meira de | |
| Autor | Moraes, Milton Ozório | |
| Fecha de acceso | 2021-04-12T14:52:55Z | |
| Fecha de disponibilización | 2021-04-12T14:52:55Z | |
| Fecha de publicación | 2021 | |
| Referencia | BARROS, Tamiris Azamor da Costa et al. Congenital Zika syndrome is associated with interferon alfa receptor 1. In: INTERNATIONAL SYMPOSIUM ON IMMUNOBIOLOGICAL, 5., 2021. Rio de Janeiro. Annals... Rio de Janeiro: Bio-Manguinhos, 2021. p. 61. | |
| URI | https://www.arca.fiocruz.br/handle/icict/46640 | |
| Descripción | Os autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz. | pt_BR |
| Idioma | eng | en_US |
| Editor | Fiocruz/Instituto de Tecnologia em Imunobiológicos | |
| Documentos relacionados | https://www.arca.fiocruz.br/handle/icict/65068 | |
| Derechos de autor | open access | |
| Palabras clave en Portugués | Síndrome congênita do zika | pt_BR |
| Palabras clave en Portugués | Interferon | pt_BR |
| Palabras clave en Portugués | Placenta | pt_BR |
| Palabras clave en Portugués | ISI | pt_BR |
| Título | Congenital Zika syndrome is associated with interferon alfa receptor 1 | en_US |
| Tipo del documento | Papers presented at events | |
| DOI | 10.35259/isi.2021_46640 | |
| Resumen en Inglés | Introduction: Congenital Zika Syndrome (CZS) in a myriad of fetal abnormalities caused by Zika Virus (ZIKV). Nevertheless, it is not clear what maternal and/or fetal factors contribute to CZS outcome. Type I and type III interferons have been reported as the main antiviral factor in Zika and other flavivirus infections. Besides, single nucleotide polymorphisms (SNPs) in these genes regulate their expression and are associated with Hepatitis C, and Yellow Fever vaccination outcomes. Objective: Here, we aimed to analyze whether interferon alfa receptor 1 (IFNAR1) and interferon lambda 2 and 4 (IFNL2/4) SNPs could contribute to CZS outcome and its functional consequences in ZIKV congenital infections. Methodology: First, we selected In silico target IFNAR1 and IFNL2/4 SNPs performing Principal Components Analysis using EIGENSOFT 4.2 with data from 1000 Genomes Project phase 3, followed by ANNOVAR analysis. Then, we conducted a case-control study with 143 newborns and 153 mothers with confirmed ZIKV infection during pregnancy, and genotyped the selected SNPs by allelic discrimination. Case-control study was adjusted using a panel of 46-indels ancestry informative markers. Placenta from ZIKV-infected pregnant was analyzed by ZIKV PCR, histology and gene expression by Fluidigm microfluid qRT-PCR system. Results: Newborns carrying CG/CC genotypes of rs2257167 in IFNAR1 presented higher risk of developing CZS (OR=3.58; IC=1.42-9.04; Pcorrected=0.0225). No association between IFNL2/4 SNPs and CZS was observed. Placenta from CZS cases displayed lower levels of IFNL2 and ISG15 along with higher IFIT5. The rs2257167 CG/CC placentas also demonstrated high levels of IFIT5 and inflammationrelated genes. Conclusion: Here we found CZS to be associated with exacerbated type I IFN and insufficient type III IFN in placenta at term, forming an unbalanced response modulated by the IFNAR1 rs2257167 genotype. These findings shed light on the host-pathogen interaction focusing on the genetically regulated type I / type III IFN axis that could lead to better management of Zika and other TORCH (Toxoplasma, Others, Rubella, Cytomegalovirus, Herpes) congenital infections. Additionally, custom pharmacological interventions could be used to modulate immunity and inflammation towards protective responses. | en_US |
| Afiliación | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | |
| Afiliación | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | |
| Afiliación | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | |
| Afiliación | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | |
| Afiliación | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | |
| Afiliación | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | |
| Afiliación | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | |
| Palavras clave en Inglês | Congenital Zika Syndrome | en_US |
| Palavras clave en Inglês | Interferon | en_US |
| Palavras clave en Inglês | Placenta | en_US |
| Palavras clave en Inglês | International Symposium on Immunobiologicals | en_US |
| DeCS | Infecção por Zika virus | pt_BR |
| DeCS | Interferons | pt_BR |
| DeCS | Placenta | pt_BR |
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