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AutorTegally, Houriiyiah
AutorWilkinson, Eduan
AutorGiovanetti, Marta
AutorIranzadeh, Arash
AutorFonseca, Vagner
AutorGiandhari, Jennifer
AutorDoolabh, Deelan
AutorPillay, Sureshnee
AutorSan, Emmanuel James
AutorMsomi, Nokukhanya
AutorMlisana, Koleka
Autorvon Gottberg, Anne
AutorWalaza, Sibongile
AutorAllam, Mushal
AutorIsmail9, Arshad
AutorMohale, Thabo
AutorGlass, Allison J. G
AutorEngelbrecht, Susan
AutorVan Zyl, Gert
AutorPreiser, Wolgang
AutorPetruccione, Francesco
AutorSigal, Alex
AutorHardie, Diana
AutorMarais, Gert
AutorHsiao, Nei-yuan
AutorKorsman, Stephen
AutorDavies, Mary-Ann
AutorTyers, Lynn
AutorMudau, Innocent
AutorYork, Denis
AutorMaslo, Caroline
AutorGoedhals, Dominique
AutorAbrahams, Shareef
AutorLaguda-Akingba, Oluwakemi
AutorAlisoltani-Dehkord, Arghavan
AutorGodzik, Adam
AutorWibmer, Constantinos Kurt
AutorSewell, Bryan Trevor
AutorLourenço, José
AutorAlcantara, Luiz Carlos Junior
AutorPond, Sergei L. Kosakovsky
AutorWeaver, Steven
AutorMartin, Dareen
AutorLessells, Richard J.
AutorBhiman, JInal N.
AutorWilliamson, Carolyn
AutorOliveira, Tulio de
Data de acesso2021-04-12T18:25:57Z
Data de disponibilização2021-04-12T18:25:57Z
Data do publicação2021
CitaçãoTEGALLY, Houriiyah et al. Detection of a SARS-CoV-2 variant of concern in South Africa. Nature, p. 1-22, Mar. 2021.pt_BR
ISSN1476-4687pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/46649
Idiomaengpt_BR
EditorNaturept_BR
Direito Autoralopen access
Palavras-chaveSARS-CoV-2pt_BR
Palavras-chaveVariantept_BR
Palavras-chaveÁfrica do Sulpt_BR
Palavras-chaveDetecçãopt_BR
TítuloDetection of a SARS-CoV-2 variant of concern in South Africapt_BR
Tipo do documentoArticle
DOI10.1038/s41586-021-03402-9
Resumo em InglêsContinued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating conditions for substantial evolutionary changes to the virus1,2. Here we describe a newly arisen lineage of SARS-CoV-2 (designated 501Y.V2; also known as B.1.351 or 20H) that is defined by eight mutations in the spike protein, including three substitutions (K417N, E484K and N501Y) at residues in its receptor-binding domain that may have functional importance3,4,5. This lineage was identified in South Africa after the first wave of the epidemic in a severely affected metropolitan area (Nelson Mandela Bay) that is located on the coast of the Eastern Cape province. This lineage spread rapidly, and became dominant in Eastern Cape, Western Cape and KwaZulu–Natal provinces within weeks. Although the full import of the mutations is yet to be determined, the genomic data—which show rapid expansion and displacement of other lineages in several regions—suggest that this lineage is associated with a selection advantage that most plausibly results from increased transmissibility or immune escape.pt_BR
AfiliaçãoKwaZulu–Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences. University of KwaZulu–Natal. Durban, South Africa.pt_BR
AfiliaçãoKwaZulu–Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences. University of KwaZulu–Natal. Durban, South Africa.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Laboratório de Genética Celular e Molecular. BeloHorizonte, MG, Brasil. rpt_BR
AfiliaçãoComputational Biology Division, Department of Integrative Biomedical Sciences, University of Cape Town. Cape Town, South Africa.pt_BR
AfiliaçãoKwaZulu–Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences. University of KwaZulu–Natal. Durban, South Africa / Universidade Federal de Minas Gerais. Laboratório de Genética Celular e Molecular. BeloHorizonte, MG, Brasil.pt_BR
AfiliaçãoComputational Biology Division, Department of Integrative Biomedical Sciences, University of Cape Town. Cape Town, South Africa.pt_BR
AfiliaçãoDivision of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town. Cape Town, South Africa.pt_BR
AfiliaçãoComputational Biology Division, Department of Integrative Biomedical Sciences, University of Cape Town. Cape Town, South Africa.pt_BR
AfiliaçãoComputational Biology Division, Department of Integrative Biomedical Sciences, University of Cape Town. Cape Town, South Africa.pt_BR
AfiliaçãoComputational Biology Division, Department of Integrative Biomedical Sciences, University of Cape Town. Cape Town, South Africa..pt_BR
AfiliaçãoNHLS. Johannesburg, South Africa / Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.pt_BR
AfiliaçãoNational Institute for Communicable Diseases, NHLS. Johannesburg, South Africa / School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.pt_BR
AfiliaçãoNational Institute for Communicable Diseases, NHLS. Johannesburg, South Africa / School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africapt_BR
AfiliaçãoNational Institute for Communicable Diseases, NHLS. Johannesburg, South Africa.pt_BR
AfiliaçãoNational Institute for Communicable Diseases, NHLS. Johannesburg, South Africapt_BR
AfiliaçãoNational Institute for Communicable Diseases, NHLS. Johannesburg, South Africapt_BR
AfiliaçãoSchool of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa / Department of Molecular Pathology, Lancet Laboratories, Johannesburg, South Africa.pt_BR
AfiliaçãoDivision of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University and NHLS Tygerberg Hospital, Cape Town, South Africa.pt_BR
AfiliaçãoDivision of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University and NHLS Tygerberg Hospital, Cape Town, South Africa.pt_BR
AfiliaçãoDivision of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University and NHLS Tygerberg Hospital, Cape Town, South Africa.pt_BR
AfiliaçãoCentre for Quantum Technology, University of KwaZulu–Natal, Durban, South Africa / National Institute for Theoretical Physics (NITheP), University of KwaZulu–Natal, Durban, South Africa.pt_BR
AfiliaçãoAfrica Health Research Institute, Durban, South Africa / School of Laboratory Medicine and Medical Sciences, University of KwaZulu– Natal, Durban, South Africa / Max Planck Institute for Infection Biology, Berlin, Germany.pt_BR
AfiliaçãoDivision of Medical Virology, NHLS Groote Schuur Hospital, University of Cape Town.Cape Town, South Africa.pt_BR
AfiliaçãoDivision of Medical Virology, NHLS Groote Schuur Hospital, University of Cape Town.Cape Town, South Africa.pt_BR
AfiliaçãoDivision of Medical Virology, NHLS Groote Schuur Hospital, University of Cape Town.Cape Town, South Africa.pt_BR
AfiliaçãoDivision of Medical Virology, NHLS Groote Schuur Hospital, University of Cape Town.Cape Town, South Africa.pt_BR
AfiliaçãoCentre for Infectious Disease Epidemiology and Research, University of Cape Town. Cape Town, South Africa / Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa..pt_BR
AfiliaçãoCentre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa.pt_BR
AfiliaçãoCentre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa.pt_BR
AfiliaçãoMolecular Diagnostics Services, Durban, South Africa.pt_BR
AfiliaçãoMolecular Diagnostics Services, Durban, South Africa.pt_BR
AfiliaçãoDivision of Virology, NHLS Universitas Academic Laboratories, University of The Free State, Bloemfontein, South Africa.pt_BR
AfiliaçãoNHLS, Port Elizabeth, South Africa.pt_BR
AfiliaçãoNHLS, Port Elizabeth, South Africa / Department of Laboratory Medicine and Pathology, Faculty of Health Sciences, Walter Sisulu University, Mthatha, South Africa.pt_BR
AfiliaçãoDivision of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa./ Division of Biomedical Sciences, University of California Riverside School of Medicine, Riverside, CA, USA.pt_BR
AfiliaçãoDivision of Biomedical Sciences, University of California Riverside School of Medicine, Riverside, CA, USA.pt_BR
AfiliaçãoNational Institute for Communicable Diseases, NHLS, Johannesburg, South Africa.pt_BR
AfiliaçãoNational Institute for Communicable Diseases, NHLS, Johannesburg, South Africa.pt_BR
AfiliaçãoDepartment of Zoology, University of Oxford, Oxford, UK.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Laboratório de Genética Celular e Molecular. BeloHorizonte, MG, Brasil.pt_BR
AfiliaçãoInstitute for Genomics and Evolutionary Medicine. Temple University, Philadelphia, PA, USA.pt_BR
AfiliaçãoInstitute for Genomics and Evolutionary Medicine. Temple University, Philadelphia, PA, USA.pt_BR
AfiliaçãoComputational Biology Division, Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa / Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africapt_BR
AfiliaçãoKwaZulu–Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, University of KwaZulu–Natal, Durban, South Africa / KwaZulu–Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, University of KwaZulu–Natal, Durban, South Africa.pt_BR
AfiliaçãoNational Institute for Communicable Diseases, NHLS, Johannesburg, South Africa / School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.pt_BR
AfiliaçãoDivision of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa / Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa / Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.pt_BR
AfiliaçãoKwaZulu–Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences. University of KwaZulu–Natal. Durban, South Africa / Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa / Department of Global Health, University of Washington, Seattle, WA, USA.pt_BR
Palavras-chave em inglêsSARS-CoV-2pt_BR
Palavras-chave em inglêsVariantpt_BR
Palavras-chave em inglêsSouth Africapt_BR
Palavras-chave em inglêsDetectionpt_BR


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