| Author | Victoni, Tatiana | |
| Author | Barreto, Emiliano | |
| Author | Lagente, Vincent | |
| Author | Carvalho, Vinicius F. | |
| Access date | 2021-04-20T14:39:14Z | |
| Available date | 2021-04-20T14:39:14Z | |
| Document date | 2021 | |
| Citation | VICTONI, Tatiana et al. Oxidative Imbalance as a Crucial Factor in Inflammatory Lung Diseases: Could Antioxidant Treatment Constitute a New Therapeutic Strategy?. Oxidative Medicine and Cellular Longevity, Vol. 2021, Article ID 6646923, 11p, 2021. | pt_BR |
| ISSN | 1942-0994 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/46790 | |
| Language | eng | pt_BR |
| Publisher | Hindawi | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Desequilíbrio Oxidativo | pt_BR |
| Subject in Portuguese | Fator Crucial | pt_BR |
| Subject in Portuguese | Doenças inflamatórias de Pulmão | pt_BR |
| Subject in Portuguese | Tratamento antioxidante | pt_BR |
| Subject in Portuguese | Nova Estratégica terapêutica ? | pt_BR |
| Title | Oxidative Imbalance as a Crucial Factor in Inflammatory Lung Diseases: Could Antioxidant Treatment Constitute a New Therapeutic Strategy? | pt_BR |
| Type | Article | |
| DOI | 10.1155/2021/6646923 | |
| Abstract | Inflammatory lung disease results in a high global burden of death and disability. There are no effective treatments for the most
severe forms of many inflammatory lung diseases, such as chronic obstructive pulmonary disease, emphysema, corticosteroid resistant asthma, and coronavirus disease 2019; hence, new treatment options are required. Here, we review the role of oxidative
imbalance in the development of difficult-to-treat inflammatory lung diseases. The inflammation-induced overproduction of
reactive oxygen species (ROS) means that endogenous antioxidants may not be sufficient to prevent oxidative damage, resulting
in an oxidative imbalance in the lung. In turn, intracellular signaling events trigger the production of proinflammatory
mediators that perpetuate and aggravate the inflammatory response and may lead to tissue damage. The production of high
levels of ROS in inflammatory lung diseases can induce the phosphorylation of mitogen-activated protein kinases, the
inactivation of phosphoinositide 3-kinase (PI3K) signaling and histone deacetylase 2, a decrease in glucocorticoid binding to its
receptor, and thus resistance to glucocorticoid treatment. Hence, antioxidant treatment might be a therapeutic option for
inflammatory lung diseases. Preclinical studies have shown that antioxidants (alone or combined with anti-inflammatory drugs)
are effective in the treatment of inflammatory lung diseases, although the clinical evidence of efficacy is weaker. Despite the high
level of evidence for the efficacy of antioxidants in the treatment of inflammatory lung diseases, the discovery and clinical
investigation of safer, more efficacious compounds are now a priority. | pt_BR |
| Affilliation | University of Lyon. VetAgro Sup. APCSe, Marcy l'Étoile, France. | pt_BR |
| Affilliation | Universidade federal de Alagoas. Laboratório de Biologia Celular. Maceió, AL, Brasil. | pt_BR |
| Affilliation | NuMeCan Institute (Nutrition, Metabolism and Cancer), INSERM, INRAE, CHU Rennes, Univ Rennes, Rennes, France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de IInflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Oxidative Imbalance | pt_BR |
| Subject | Crucial Factor | pt_BR |
| Subject | nflammatory Lung Diseases | pt_BR |
| Subject | Antioxidant Treatment | pt_BR |
| Subject | New Therapeutic Strategy? | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
