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| Autor | Sousa, Ricardo Augusto Leoni de | |
| Autor | Caria, Alex Cleber Improta | |
| Autor | Souza, Bruno Solano de Freitas | |
| Fecha de acceso | 2021-04-24T13:35:48Z | |
| Fecha de disponibilización | 2021-04-24T13:35:48Z | |
| Fecha de publicación | 2021 | |
| Referencia | SOUSA, Ricardo Augusto Leoni de; CARIA, Alex Cleber Improta; SOUZA, Bruno Solano de Freitas. Exercise–Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes. International Journal of Molecular Sciences, v. 22, p. 1-15, 2021. | pt_BR |
| ISSN | 1661-6596 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/46875 | |
| Promoción | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brazil (CAPES)—Finance Code 001. | pt_BR |
| Idioma | eng | pt_BR |
| Editor | MDPI | pt_BR |
| Derechos de autor | open access | pt_BR |
| Palabras clave en Portugués | Exercício físico | pt_BR |
| Palabras clave en Portugués | Resistência a insulina | pt_BR |
| Palabras clave en Portugués | Diabetes Mellitus Tipo 2 | pt_BR |
| Palabras clave en Portugués | Cognição | pt_BR |
| Palabras clave en Portugués | Complicações | pt_BR |
| Palabras clave en Portugués | Hiperglicemia | pt_BR |
| Título | Exercise–Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes | pt_BR |
| Tipo del documento | Article | pt_BR |
| DOI | 10.3390/ijms22042199 | |
| Resumen en Inglés | Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with insulin resistance and hyperglycemia. Chronic exposure to a T2DM microenvironment with hyperglycemia, hyperinsulinemia, oxidative stress and increased levels of proinflammatory mediators, has negative consequences to the cardiovascular system and mental health. Therefore, atherosclerotic cardiovascular diseases (CVD) and mental health issues have been strongly associated with T2DM. Lifestyle modifications, including physical exercise training, are necessary to prevent T2DM development and its associated complications. It is widely known that the regular practice of exercise provides several physiological benefits to subjects with T2DM, such as managing glycemic and blood pressure levels. Different types of exercise, from aerobic to resistance training, are effective to improve mental health and cognitive function in T2DM. Irisin is a myokine produced in response to exercise, which has been pointed as a relevant mechanism of action to explain the benefits of exercise on cardiovascular and mental health in T2DM patients. Here, we review emerging clinical and experimental evidence about exercise-linked irisin consequences to cardiovascular and mental health in T2DM. | pt_BR |
| Afiliación | Multicenter Post Graduation Program in Physiological Sciences, Brazilian Society of PhysiologyFederal University of the Valleys of Jequitinhonha and Mucuri. Diamantina, MG, Brazil / Federal University of the Valleys of Jequitinhonha and Mucuri. Neuroscience and Exercise Study Group. Diamantina, MG, Brazil. | pt_BR |
| Afiliación | Federal University of Bahia. Faculty of Medicine. Post-Graduate Program in Medicine and Health. Salvador, BA, Brazil / Brazilian Society of Cardiology. Department of Physical Education in Cardiology. Salvador, BA , Brazil / São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil. | pt_BR |
| Afiliación | São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Palavras clave en Inglês | Physical activity | pt_BR |
| Palavras clave en Inglês | Insulin resistance | pt_BR |
| Palavras clave en Inglês | Inflammation | pt_BR |
| Palavras clave en Inglês | Cognitive decline | pt_BR |
| Palavras clave en Inglês | Memory | pt_BR |
| Palavras clave en Inglês | Dementia | pt_BR |
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