| Author | Moreira, Rodrigo Carvalho | |
| Author | Miranda, Mariana Alencar | |
| Author | Muller, Jessica | |
| Author | Cardoso, Sandra Wagner | |
| Author | Moreira, Ronaldo Ismerio | |
| Author | Nunes, Estevão | |
| Author | Griep, Rosane H. | |
| Author | Fonseca, Maria Jesus | |
| Author | Veloso, Valdiléa G. | |
| Author | Grinsztejn, Beatriz | |
| Author | Chor, Dóra | |
| Author | Pacheco, Antonio Guilherme | |
| Access date | 2021-05-01T13:14:30Z | |
| Available date | 2021-05-01T13:14:30Z | |
| Document date | 2021 | |
| Citation | MOREIRA, Rodrigo Carvalho et al. Factors Associated with Incident Cardiovascular Events and Cardiac Risk Assessment in a Cohort of HIV-infected Participants in Rio de Janeiro. International Journal of Infectious Diseases and Therapy, v. 6, n. 1, p. 17-26, 2021. | pt_BR |
| ISSN | 2578-9651 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/46993 | |
| Language | eng | pt_BR |
| Publisher | Science Publishing Group | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Síndrome da Imunodeficiência Adquirida | pt_BR |
| Subject in Portuguese | Doenças Cardiovasculares | pt_BR |
| Subject in Portuguese | Avaliação do risco | pt_BR |
| Title | Factors associated with incident cardiovascular events and cardiac risk assessment in a cohort of hiv-infected participants in Rio de Janeiro | pt_BR |
| Type | Article | |
| DOI | 10.11648/j.ijidt.20210601.13 | |
| Abstract | Background: Cardiovascular events (CVEs) have emerged as an important cause of morbimortality in people
living with HIV/AIDS (PLHA). We aimed to investigate factors associated with incident CVE and compare the observed
incidence with the predicted CVE risk by three different equations. Methods: Among the 649 active participants of the INI ELSA cohort, we analysed data of 644 individuals free of CVE at baseline examinations. We used Cox regression models to
study factors associated with CVE and to assess the equation's performance we compared the observed incidence with the
overall 5-year predicted risks. Results: Over a median follow-up of 6.26-years (interquartile range [IQR] 6.01-6.47), there were
18 CVE, four deaths. Overall, 57.92% were male, median age was 43.4 years (35.82-50.73), most were on cART (88.65%).
Participants who had CVE were older, had poorer renal function, higher proportion of dyslipidemia and higher levels of
systolic blood pressure and triglycerides. The observed CVE rate was 2.90% (1.60-4.90%) whereas their overall cardiovascular
disease (CVD) risk differed depending on which score was used: 0.91 (0.42-20), 1.16 (0.38-2.78) and 1.68 (0.60-3.87),
according to Framingham, ASCVD and DAD, respectively. In the multivariable Cox analysis black race, smoking 10+ packs
years, dyslipidemia, current CD4 cell count x101
, cumulative viral load and time on NNRTI were independent predictors of
CVE. Conclusion: Both traditional and HIV-related factors were associated with incident CVE. Risk scores were inconsistent
in classifying patients who had CVE as high risk, indicating that validation studies are required to improve risk assessment of
PLHA in Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Medicina Interna. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Medicina Interna. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil | pt_BR |
| Subject | Acquired Immunodeficiency Syndrome | pt_BR |
| Subject | Cardiovascular Disease | pt_BR |
| Subject | Risk Assessment | pt_BR |
| e-ISSN | 2578-966X | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
