| Author | Nery, José Augusto da Costa | |
| Author | Salles, Anna Maria | |
| Author | Hacker, Mariana de Andrea Vilas-Boas | |
| Author | Moraes, Milton Ozório | |
| Author | Maia, Raquel Cristina | |
| Author | Sarno, Euzenir Nunes | |
| Author | Illarramendi Rojas, Ximena | |
| Access date | 2021-05-06T18:36:50Z | |
| Available date | 2021-05-06T18:36:50Z | |
| Document date | 2021 | |
| Citation | NERY, José Augusto da Costa et al. Low rate of relapse after twelve-dose multidrug therapy for hansen's disease: a 20-year cohort study in a brazilian reference center. PLoS Neglected Tropical Diseases, v. 15, n. 5, p. 1-12, 3 May 2021. | |
| ISSN | 1935-2727 | |
| URI | https://www.arca.fiocruz.br/handle/icict/47088 | |
| Description | Produção científica do Laboratório de Hanseníase. | pt_BR |
| Sponsorship | The authors received no specific funding for this work. | |
| Language | eng | en_US |
| Publisher | Public Library of Science | |
| Later version | https://www.arca.fiocruz.br/handle/icict/65749 | |
| Related document | https://www.arca.fiocruz.br/handle/icict/46365 | |
| Rights | open access | |
| Subject in Portuguese | Hanseníase | pt_BR |
| Subject in Portuguese | Baixa taxa de recidiva | pt_BR |
| Subject in Portuguese | Doze doses terapia multidroga | pt_BR |
| Subject in Portuguese | Estudo de coorte | pt_BR |
| Subject in Portuguese | Centro de referência brasileiro | pt_BR |
| Title | Low rate of relapse after twelve-dose multidrug therapy for hansen's disease: a 20-year cohort study in a brazilian reference center | en_US |
| Type | Preprint | |
| DOI | 10.1371/journal.pntd.0009382 | |
| Abstract | The World Health Organization has raised concerns about the increasing number of Hansen disease (HD) relapses worldwide, especially in Brazil, India, and Indonesia that report the highest number of recurrent cases. Relapses are an indicator of MDT effectiveness and can reflect Mycobacterium leprae persistence or re-infection. Relapse is also a potential marker for the development or progression of disability. In this research, we studied a large cohort of persons affected by HD treated with full fixed-dose multibacillary (MB) multidrug therapy (MDT) followed for up to 20 years and observed that relapses are a rare event. We esti mated the incidence density of relapse in a cohort of patients classified to receive MB regime (bacillary index (BI) > 0), diagnosed between September 1997 and June 2017, and treated with twelve-dose MB-MDT at a HD reference center in Rio de Janeiro, Brazil. We obtained the data from the data management system of the clinic routine service. We linked the selected cases to the dataset of relapses of the national HD data to confirm possible relapse cases diagnosed elsewhere. We diagnosed ten cases of relapse in a cohort of 713 patients followed-up for a mean of 12.1 years. This resulted in an incidence rate of 1.16 relapse cases per 1000 person-year (95% CI = 0.5915–2.076). The accumulated risk was 0.025 in 20 years. The very low risk observed in this cohort of twelve-dose-treated MB patients rein forces the success of the current MDT scheme. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Ambulatório Souza Araujo. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Ambulatório Souza Araujo. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Ambulatório Souza Araujo. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Ambulatório Souza Araujo. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Ambulatório Souza Araujo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil. | |
| Subject | Hansen's disease | en_US |
| Subject | Low rate | en_US |
| Subject | Relapse | en_US |
| Subject | Twelve-dose multidrug therapy | en_US |
| Subject | Brazilian reference center | en_US |
| e-ISSN | 1935-2735 | |
