| Author | Carvalho, Gustavo C. Nascimento | pt_BR |
| Author | Carvalho, Eduardo C. Nascimento | pt_BR |
| Author | Ramos, Clara L. | pt_BR |
| Author | Vilas‑Boas, Ana Luisa | pt_BR |
| Author | Carvalho, Otávio A. Moreno | pt_BR |
| Author | Vinhaes, Caian L. | pt_BR |
| Author | Duarte, Beatriz Barreto | pt_BR |
| Author | Queiroz, Artur Trancoso Lopo de | pt_BR |
| Author | Andrade, Bruno de Bezerril | pt_BR |
| Author | Carvalho, Cristiana M. Nascimento | pt_BR |
| Access date | 2021-05-11T17:40:30Z | |
| Available date | 2021-05-11T17:40:30Z | |
| Document date | 2021 | |
| Citation | CARVALHO, Gustavo C. Nascimento et al. Zika‑exposed microcephalic neonates exhibit higher degree of inflammatory imbalance in cerebrospinal fluid. Scientific Reports, v. 11, n. 8474, p. 1-10, 19 Apr. 2021. | pt_BR |
| ISSN | 2045-2322 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/47131 | |
| Sponsorship | Fundação Oswaldo Cruz | pt_BR |
| Sponsorship | Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Brazil | pt_BR |
| Sponsorship | National Institutes of Allergy and Infectious Diseases, National Institutes of Health [Grant Numbers U01AI115940, U01AI069923] | pt_BR |
| Sponsorship | Brazilian Council for Scientific and Technological Development (CNPq) [Grant Number 313466/2018-1] | pt_BR |
| Language | eng | pt_BR |
| Publisher | Nature Research | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Biomarcadores | pt_BR |
| Subject in Portuguese | Imunologia | pt_BR |
| Subject in Portuguese | Zika virus | pt_BR |
| Subject in Portuguese | Microcefalia | pt_BR |
| Subject in Portuguese | Recém-nascido | pt_BR |
| Subject in Portuguese | Infecções | pt_BR |
| Subject in Portuguese | Mediadores da inflamação | pt_BR |
| Title | Zika‑exposed microcephalic neonates exhibit higher degree of inflammatory imbalance in cerebrospinal fluid | en |
| Type | Article | pt_BR |
| DOI | 10.1038/s41598-021-87895-4 | pt_BR |
| Abstract | Not every neonate with congenital Zika virus (ZIKV) infection (CZI) is born with microcephaly. We compared inflammation mediators in CSF (cerebrospinal fluid obtained from lumbar puncture) between ZIKV‑exposed neonates with/without microcephaly (cases) and controls. In Brazil, in the same laboratory, we identified 14 ZIKV‑exposed neonates during the ZIKV epidemic (2015–2016), 7(50%) with and 7(50%) without microcephaly, without any other congenital infection, and 14 neonates (2017–2018) eligible to be controls and to match cases. 29 inflammation mediators were measured using Luminex immunoassay and multidimensional analyses were employed. Neonates with ZIKV‑associated microcephaly presented substantially higher degree of inflammatory perturbation, associated with uncoupled inflammatory response and decreased correlations between concentrations of inflammatory biomarkers. The groups of microcephalic and non‑microcephalic ZIKV‑exposed neonates were distinguished from the control group (area under curve [AUC] = 1; P < 0.0001). Between controls and those non‑microcephalic exposed to ZIKV, IL‑1β, IL‑3, IL‑4, IL‑7 and EOTAXIN were the top CSF markers. By comparing the microcephalic cases with controls, the top discriminant scores were for IL‑1β, IL‑3, EOTAXIN and IL‑12p70. The degree of inflammatory imbalance may be associated with microcephaly in CZI and it may aid additional investigations in experimental pre‑clinical models testing immune modulators in preventing extensive damage of the Central Nervous System. | en |
| Affilliation | Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
| Affilliation | José Silveira Foundation. Laboratório de Líquido Cefalorraquidiano. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Universidade Salvador. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Universidade Salvador. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Faculdade de Medicina. Salvador, BA, Brasil / University of Cape Town. Institute of Infectious Disease and Molecular Medicine. Wellcome Centre for Infectious Disease Research in Africa. Cape Town, South Africa / Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, TN, USA. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Departamento de Pediatria. Salvador, BA, Brasil. | pt_BR |
| Subject | Biomarkers | en |
| Subject | Immunology | en |
| Subject | Zika virus | en |
| Subject | Microcephaly | en |
| Subject | Newborn | en |
| Subject | Infection | en |
| Subject | Inflammation mediators | en |
