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AutorFerreira, Fátima Cristiane Pinho de Almeida Di Maiopt_BR
AutorSilva, Anamaria Szrajbman Vaz dapt_BR
AutorRecht, Judithpt_BR
AutorGuaraldo, Lusielept_BR
AutorMoreira, Maria Elisabeth Lopespt_BR
AutorSiqueira, André Machado dept_BR
AutorGerardin, Patrickpt_BR
AutorBrasil, Patríciapt_BR
Data de acesso2021-05-21T14:04:17Z
Data de disponibilização2021-05-21T14:04:17Z
Data do publicação2021
CitaçãoFERREIRA, Fátima Cristiane Pinho de Almeida Di Maio et al. Vertical transmission of chikungunya virus: a systematic review. PloS One, v. 16, n. 4, p. 1-19, 2021.pt_BR
ISSN1932-6203pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/47289
Idiomaengpt_BR
EditorPublic Library of Sciencept_BR
Direito Autoralopen access
TítuloVertical transmission of chikungunya virus: a systematic reviewen
Tipo do documentoArticlept_BR
DOI10.1371/journal.pone.0249166pt_BR
Resumo em InglêsObjectives: To describe and estimate the frequency of pregnancy outcomes, clinical and laboratory characteristics of vertical transmission of CHIKV in the neonate. Study design: We performed a systematic review evaluating the clinical presentation of perinatally-acquired CHIKV infection in neonates. The search was performed using Medline (via PubMed), LILACS, Web of Science, Scielo, Google Scholar and Open grey to identify studies assessing vertical transmission of CHIKV up to November 3, 2020. There were no search restrictions regarding the study type, the publication date or language. Studies with no documented evidence of CHIKV infection in neonates (negative RT-PCR or absence of IgM) were excluded. Results: From the 227 studies initially identified, 42 were selected as follows: 28 case reports, 7 case series, 2 cross-sectional studies and 5 cohort studies, for a total of 266 CHIKV infected neonates confirmed by serological and/or molecular tests. The vertical transmission rate was 50% in the Reunion Island outbreak, which was the subject of the majority of the studies; the premature delivery were reported in 19 (45.2%) studies; the rate of fetal distress was 19.6% of infected babies and fetal loss occurred in 2% of the cases. Approximately 68.7% of newborns were diagnosed with encephalopathy or encephalitis after perinatally acquired CHIKV. Most of the infected neonates were born healthy, developing CHIKV sepsis clinical syndrome within the first week of life. Conclusions: We alert neonatologists to the late manifestations of neonatal CHIKV infection, relevant to the management and reduction of morbidity. A limitation of our review was that it was not possible to carry out meta-analysis due to differences in study design and the small number of participants.pt_BR
AfiliaçãoUniversidade Federal do Estado do Rio de Janeiro. Departamento de Neonatologia. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaçãoUniversidade Federal do Estado do Rio de Janeiro. Departamento de Neonatologia. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaçãoIndependent Consultant. Maryland, United States of America.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Departamento de Neonatologia. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaçãoGroupe Hospitalier Sud Réunion. Reunion Island, France.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.pt_BR
Palavras-chave em inglêsHemorrhagic feverspt_BR
Palavras-chave em inglêsChikungunya viruspt_BR
Palavras-chave em inglêsNeonatespt_BR
Palavras-chave em inglêsArthralgiapt_BR
Palavras-chave em inglêsThrombocytopeniapt_BR


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