| Author | Granja, Marcelo Gomes | |
| Author | Oliveira, Amanda Candida da Rocha | |
| Author | Figueiredo, Camila Saggioro de | |
| Author | Gomes, Alex Portes | |
| Author | Ferreira, Erica Camila | |
| Author | Araujo, Elizabeth Giestal de | |
| Author | Faria Neto, Hugo Caire de Castro | |
| Access date | 2021-05-25T18:49:03Z | |
| Available date | 2021-05-25T18:49:03Z | |
| Document date | 2021 | |
| Citation | GRANJA, Marcelo Gomes et al. SARS-CoV-2 Infection in Pregnant Women: Neuroimmune-Endocrine Changes at the Maternal-Fetal Interface. Neuroimmunomodulation, v. 28, 32p, Apr. 2021 | pt_BR |
| ISSN | 1021-7401 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/47365 | |
| Language | eng | pt_BR |
| Publisher | Karger Publishers | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Doença do coronavírus 2019 | pt_BR |
| Subject in Portuguese | Coronavírus 2 relacionado à síndrome respiratória aguda grave | pt_BR |
| Subject in Portuguese | Gravidez | pt_BR |
| Subject in Portuguese | Neurodevelopment | pt_BR |
| Subject in Portuguese | Interface materno-fetal | pt_BR |
| Subject in Portuguese | Interações neuroimunes | pt_BR |
| Title | SARS-CoV-2 Infection in Pregnant Women: Neuroimmune-Endocrine Changes at the Maternal-Fetal Interface | pt_BR |
| Type | Article | |
| DOI | 10.1159/000515556 | |
| Abstract | Coronavirus disease 2019 (COVID-19) caused by severe
acute respiratory syndrome-related coronavirus 2 (SARS CoV-2) has devastating effects on the population worldwide.
Given this scenario, the extent of the impact of the disease
on more vulnerable individuals, such as pregnant women, is
of great concern. Although pregnancy may be a risk factor in
respiratory virus infections, there are no considerable differ ences regarding COVID-19 severity observed between preg nant and nonpregnant women. In these circumstances, an
emergent concern is the possibility of neurodevelopmental
and neuropsychiatric harm for the offspring of infected
mothers. Currently, there is no stronger evidence indicating
vertical transmission of SARS-CoV-2; however, the exacer bated inflammatory response observed in the disease could
lead to several impairments in the offspring’s brain. Further more, in the face of historical knowledge on possible long term consequences for the progeny’s brain after infection by
viruses, we must consider that this might be another delete rious facet of COVID-19. In light of neuroimmune interac tions at the maternal-fetal interface, we review here the pos sible harmful outcomes to the offspring brains of mothers
infected by SARS-CoV-2. | pt_BR |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro - UNIRIO. Programa de Biologia Celular e Molecular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Programa de Neurociência. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Programa de Neurociência. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Programa de Ciências Médicas, Neurologia e Neurociências. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Programa de Neurociência. Niterói, RJ, Brasil / Instituto Nacional de Tecnologia-Neuroimunomodulação-INCT-NIM. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Tecnologia-Neuroimunomodulação-INCT-NIM. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Coronavirus disease 2019 | pt_BR |
| Subject | Severe acute respiratory syndrome-related coronavirus 2 | pt_BR |
| Subject | Pregnancy | pt_BR |
| Subject | Neurodevelopment | pt_BR |
| Subject | Maternal-fetal interface | pt_BR |
| Subject | Neuroimmune interactions | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
