| Author | Sousa Jr, Ivanildo Pedro de | |
| Author | Giamberardino, Heloisa Ihle | |
| Author | Raboni, Sonia Mara | |
| Author | Debur, Maria Carmo | |
| Author | Oliveira, Maria de Lourdes Aguiar | |
| Author | Burlandy, Fernanda Marcicano | |
| Author | Silva, Edson Elias da | |
| Access date | 2021-06-05T18:34:48Z | |
| Available date | 2021-06-05T18:34:48Z | |
| Document date | 2021 | |
| Citation | SOUSA JR., Ivanildo Pedro de et al. Simultaneous enterovirus EV-D68 and CVA6 infections causing acute respiratory distress syndrome and hand, foot and mouth disease. Virology Journal, v. 18, n. 88, 6 p, 2021. | pt_BR |
| ISSN | 1743-422X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/47539 | |
| Language | eng | pt_BR |
| Publisher | BMC | pt_BR |
| Rights | open access | |
| Subject in Portuguese | EV-D68 | pt_BR |
| Subject in Portuguese | Enterovírus | pt_BR |
| Subject in Portuguese | Doença da febre aftosa | pt_BR |
| Subject in Portuguese | Síndrome do desconforto respiratório agudo | pt_BR |
| Subject in Portuguese | CVA6 | pt_BR |
| Title | Simultaneous enterovirus EV-D68 and CVA6 infections causing acute respiratory distress syndrome and hand, foot and mouth disease | pt_BR |
| Type | Article | |
| DOI | 10.1186/s12985-021-01560-w | |
| Abstract | Background: Although most enterovirus (EV) infections can be asymptomatic, these viral agents can cause serious conditions associated with central nervous system, respiratory disease and uncommon manifestations of hand,
foot and mouth disease (HFMD). EV-coinfections have been rarely reported with development of complications and
severe clinical outcome. An atypical case of a child presenting HFMD and severe acute respiratory syndrome, coinfected with EV-D68 and CVA6, is reported herein.
Case presentation: A 3-year-old boy was admitted in the emergency department unit showing fever, abdominal
pain and tachycardia. Twenty-four hours after hospitalization the child developed severe clinical symptoms associated
with HFMD and was discharged after recovery. Two days later, the child was readmitted with fever, cough and respiratory distress. RT-PCR and Sanger sequencing confrmed positivity for EV-D68 and CVA6 in oro and nasopharynges
swabs and vesicles fuid, respectively. Phylogenetic analysis based on VP1 gene sequences suggested that CVA6 was
closely related with HFMD viruses circulating in Turkey, while EV-D68 was genetically related to a Chinese strain.
Conclusions: To the best of our knowledge, this case is the frst report of a double infection caused by CVA6 and
EV-D68, which shed light on the pathogenesis of enterovirus infections. Further studies must be conducted to ascertain the role and clinical signifcance of EV co-infections, as well as a potential synergistic pathway between these
viruses. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovirus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Pequeno Príncipe. Divisão de Epidemiologia. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal Do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Secretaria de Saúde do Estado do Paraná. Laboratório de Saúde Pública. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovirus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovirus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Enterovirus | pt_BR |
| Subject | Hand, foot and mouth disease | pt_BR |
| Subject | Acute respiratory distress syndrome | pt_BR |
| Subject | EV-D68 | pt_BR |
| Subject | CVA6 | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
