| Author | Aguilar Ticona, Juan Pablo | pt_BR |
| Author | Nery Junior, Nivison Ruy Rocha | pt_BR |
| Author | Ladines-Lim, Joseph B. | pt_BR |
| Author | Gambrah, Claudia | pt_BR |
| Author | Sacramento, Gielson | pt_BR |
| Author | Freitas, Bruno de Paula | pt_BR |
| Author | Bouzon, Joseane | pt_BR |
| Author | Oliveira Filho, Jamary | pt_BR |
| Author | Borja, Ana | pt_BR |
| Author | Adhikarla, Haritha | pt_BR |
| Author | Montoya, Magelda | pt_BR |
| Author | Chin, Athena | pt_BR |
| Author | Wunder Junior, Elsio Augusto | pt_BR |
| Author | Ballalai, Verena | pt_BR |
| Author | Vieira, Carina | pt_BR |
| Author | Belfort, Rubens | pt_BR |
| Author | Almeida, Antonio R. P. | pt_BR |
| Author | Reis, Mitermayer Galvão dos | pt_BR |
| Author | Harris, Eva | pt_BR |
| Author | Ko, Albert Icksang | pt_BR |
| Author | Costa, Federico | pt_BR |
| Access date | 2021-06-14T13:40:11Z | |
| Available date | 2021-06-14T13:40:11Z | |
| Document date | 2021 | |
| Citation | AGUILAR TICONA, Juan Pablo et al. Developmental outcomes in children exposed to Zika virus in utero from a brazilian urban slum cohort study. PLoS Neglected Tropical Diseases, v. 15, n. 2, p. 1-15, 5 Feb. 2021. | pt_BR |
| ISSN | 1935-2727 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/47663 | |
| Sponsorship | National Institutes of Health (NIAID R01 AI052473 (AK), R25 U01AI088752 (AK), FIC R01 TW009504 (AK), R25 TW009338 (AK), F31 AI114245 (AK), R01 AI121207 (AK), D43 TW010540 (AK), P01 AI106695 (EH) (https://www.niaid.nih.gov/) | pt_BR |
| Sponsorship | Wellcome Trust (102330/Z/13/Z https://wellcome.ac.uk/) | pt_BR |
| Sponsorship | Bahia State Research Support Foundation (FAPESB) ZIKA-FAPESB T.O. n˚ PET0021/2016 (www.fapesb.ba.gov.br) | pt_BR |
| Sponsorship | Coordination for the Improvement of Higher Education (CAPES) from Brazil (https://www.capes.gov.br/) | pt_BR |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Zika Vírus | pt_BR |
| Subject in Portuguese | Prevalência | pt_BR |
| Subject in Portuguese | Risco | pt_BR |
| Subject in Portuguese | Soroconversão | pt_BR |
| Subject in Portuguese | Mães | pt_BR |
| Title | Developmental outcomes in children exposed to Zika virus in utero from a brazilian urban slum cohort study | en |
| Type | Article | pt_BR |
| DOI | 10.1371/journal.pntd.0009162 | pt_BR |
| Abstract | Background: The prevalence of developmental alterations associated with in-utero Zika virus (ZIKV) exposure in children is not well understood. Furthermore, estimation of the Population Attributable Fraction (PAF) of developmental alterations attributed to ZIKV has not been performed due to lack of population-based cohorts with data on symptomatic and asymptomatic ZIKV exposures and an appropriate control group. The aim of this study was to characterize neurodevelopmental outcomes of children at 11 to 32 months of age with intrauterine ZIKV exposure and estimate the PAF of alterations secondary to ZIKV exposure. Methodology/Principal findings: We performed a cohort of biannual community-based prospective serosurveys in a slum community in Salvador, Brazil. We recruited women participating in our cohort, with a documented pregnancy from January 2015 to December 2016 and children born to those mothers. Children were classified as ZIKV exposed in utero (born from women with ZIKV seroconversion during pregnancy) or unexposed (born from women without ZIKV seroconversion or that seroconverted before/after pregnancy) by using an IgG monoclonal antibody blockade-of-binding (BoB). We interviewed mothers and performed anthropometric, audiometric, ophthalmological, neurologic, and neurodevelopmental evaluations of their children at 11 to 32 months of age. Among the 655 women participating in the cohort, 66 (10%) were pregnant during the study period. 46 (70%) of them completed follow-up, of whom ZIKV seroconversion occurred before, during, and after pregnancy in 25 (54%), 13 (28%), and 1 (2%), respectively. The rest of women, 7 (21.2%), did not present ZIKV seroconversion. At 11 to 32 months of life, the 13 ZIKV-exposed children had increased risk of mild cognitive delay (RR 5.1; 95%CI 1.1–24.4) compared with the 33 children unexposed, with a PAF of 53.5%. Exposed children also had increased risk of altered auditory behavior (RR 6.0; 95% CI 1.3–26.9), with a PAF of 59.5%. Conclusions: A significant proportion of children exposed in utero to ZIKV developed mild cognitive delay and auditory behavioral abnormalities even in the absence of gross birth defects such as microcephaly and other neurodevelopmental domains. Furthermore, our findings suggest that over half of these abnormalities could be attributed to intrauterine ZIKV exposure. | en |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA. | pt_BR |
| Affilliation | Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Hospital Geral Roberto Santos. Salvador, BA, Brasil / Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Hospital Geral Roberto Santos. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Fonoaudiologia. Salvador, BA, Bahia. | pt_BR |
| Affilliation | Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA. | pt_BR |
| Affilliation | University of California. School of Public Health. Division of Infectious Diseases and Vaccinology. Berkeley, CA, USA. | pt_BR |
| Affilliation | University of California. School of Public Health. Division of Infectious Diseases and Vaccinology. Berkeley, CA, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA. | pt_BR |
| Affilliation | Hospital Geral Roberto Santos. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Hospital Geral Roberto Santos. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Hospital Geral Roberto Santos. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | University of California. School of Public Health. Division of Infectious Diseases and Vaccinology. Berkeley, CA, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA. | pt_BR |
| Subject | Zika Virus | pt_BR |
| Subject | Prevalence | en |
| Subject | Risk | en |
| Subject | Seroconversion | en |
| Subject | Mothers | en |
| e-ISSN | 1935-2735 | pt_BR |
