Author | Ribeiro, Camilla Rodrigues de Almeida | |
Author | Martinelli, Katrini Guidolini | |
Author | Mello, Vinícius da Motta de | |
Author | Baptista, Bruna da Silva | |
Author | Dias, Natália Spitz Toledo | |
Author | Paiva, Iury Amancio | |
Author | Lewis-Ximenez, Lia Laura | |
Author | Pinto, Luzia Maria de Oliveira | |
Author | Paula, Vanessa Salete de | |
Access date | 2021-06-17T14:34:30Z | |
Available date | 2021-06-17T14:34:30Z | |
Document date | 2020 | |
Citation | RIBEIRO, Camilla Rodrigues de Almeida et al. Cytokine, Genotype, and Viral Load Profile in the Acute and Chronic Hepatitis B. Viral Immunology. v. 33, n. 10, 8 p, 2020. | pt_BR |
ISSN | 0882-8245 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/47745 | |
Language | eng | pt_BR |
Publisher | Mary Ann Liebert | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Hepatite B | pt_BR |
Subject in Portuguese | Citocinas | pt_BR |
Subject in Portuguese | Resposta imune | pt_BR |
Title | Cytokine, Genotype, and Viral Load Profile in the Acute and Chronic Hepatitis B | pt_BR |
Type | Article | pt_BR |
DOI | 10.1089/vim.2020.0176 | |
Abstract | Several hepatitis B virus (HBV) factors, including viral load, genotype, genome mutations, and cytokine pro duction, have been reported to be associated with different risks of progression of liver disease. The aim of this
study was to verify if there is an association among the levels of cytokines (interleukin [IL]-35, IL-6, IL-17A,
interferon [IFN]-c) in the plasma, viral load, and the different genotypes of HBV in patients with acute or chronic
hepatitis B. Methods: 49 serum samples, 20 from acute and 29 from chronic cases, were submitted to a real-time
and nested-polymerase chain reaction to quantify, detect, and genotype HBV DNA. The cytokines IL-35, IL-6,
IL-17A, and IFN-c were detected by an enzyme-linked immunosorbent assay (ELISA). The median viral load
was 3.15 log10 IU DNA/mL and 2.90 log10 IU DNA/mL for acute and chronic patients, respectively. Genotype A,
D, E, and F were identified in chronic carriers of HBV infection, while only genotype A and F were identified in
individuals with acute infection. IFN-c ( p = 0.024) and IL-17A ( p = 0.046) levels were significantly increased in
chronic patients and IL-6 and IL-35 were higher in patients with acute infection, however, without statistical
difference. IL-17A and IFN-c can be modulating proinflammatory effects and inducing hepatocellular damage, in
chronic patients, and IL-6 and IL-35 may be involved in viral elimination and protection against chronicity during
the acute phase of infection. These results can contribute to understanding of the complex regulatory mechanisms
of the host antiviral response related to cytokine production during acute and chronic HBV infection. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Espírito Santo. Departamento de Medicina Social. Vitória, ES, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoflogia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Hepatitis B | pt_BR |
Subject | Cytokines | pt_BR |
Subject | Immune response | pt_BR |
e-ISSN | 1557-8976 | |