| Author | Aguiar, Daniele Fernandes de | |
| Author | Barros, Eliana Nogueira C. de | |
| Author | Ribeiro, Guilherme de Sousa | |
| Author | Brasil, Patricia | |
| Author | Mourao, Maria Paula Gomes | |
| Author | Luz, Kleber | |
| Author | Aoki, Francisco Hideo | |
| Author | Freitas, Andre Ricardo Ribas | |
| Author | Calvet, Guilherme Amaral | |
| Author | Oliveira, Eduardo | |
| Author | Branco, Bianca F. | |
| Author | Abreu, Ariane | |
| Author | Cheuvart, Brigitte | |
| Author | Guignard, Adrienne | |
| Author | Boer, Melanie de | |
| Author | Duarte, Ana Claudia | |
| Author | Borges, Maria Beatriz | |
| Author | Noronha, Tatiana Guimarães de | |
| Access date | 2021-06-21T16:41:57Z | |
| Available date | 2021-06-21T16:41:57Z | |
| Document date | 2021 | |
| Citation | AGUIAR, Daniele Fernandes de et al. A prospective, multicentre, cohort study to assess the incidence of dengue illness in households from selected communities in Brazil (2014−2018). International Journal of Infectious Diseases, p. 1-47, 2021. | |
| ISSN | 1201-9712 | |
| URI | https://www.arca.fiocruz.br/handle/icict/47799 | |
| Sponsorship | FAPERJ (research support foundation of Rio de Janeiro) | |
| Sponsorship | GSK group of companies | |
| Sponsorship | Faculdade de Medicina São Leopoldo Mandic | |
| Sponsorship | Bio-Manguinhos / Fiocruz | |
| Language | eng | en_US |
| Publisher | Elsevier | |
| Later version | https://www.arca.fiocruz.br/handle/icict/61467 | |
| Rights | open access | |
| Subject in Portuguese | Dengue | pt_BR |
| Subject in Portuguese | Incidência | pt_BR |
| Subject in Portuguese | Soroprevalência | pt_BR |
| Subject in Portuguese | Epidemiologia | pt_BR |
| Subject in Portuguese | Estudo de coorte multicêntrico | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | A prospective, multicentre, cohort study to assess the incidence of dengue illness in households from selected communities in Brazil (2014−2018) | en_US |
| Type | Preprint | |
| DOI | 10.1016/j.ijid.2021.04.062 | |
| Abstract | Objectives: To estimate the incidence of dengue infection across geographically distinct areas of Brazil. Methods: This prospective, household-based, cohort study enrolled participants in five areas and followed them up for up to 4 years (2014−2018). Dengue seroprevalence was assessed at each scheduled visit. Suspected dengue cases were identified through enhanced passive and active surveillance. Acute symptomatic dengue infection was confirmed through reverse-transcriptase quantitative polymerase chain reaction in combination with an antigenic assay (NS1) and serology. Results: Among 3300 participants enrolled, baseline seroprevalence was 76.2%, although only 23.3% of participants reported a history of dengue. Of 1284 suspected symptomatic dengue cases detected, 50 (3.9%) were laboratory-confirmed. Based on 8166.5 person-years (PY) of follow-up, the incidence of laboratory-confirmed symptomatic infection (primary endpoint) was 6.1 per 1000 PY (95% confidence interval [CI]: 4.5, 8.1). Incidence varied substantially in different years (1.8−7.4 per 1000 PY). The incidence of inapparent primary dengue infection was substantially higher: 41.7 per 1000 PY (95% CI: 31.1, 54.6). Conclusions: Our findings, highlighting that the incidence of dengue infection is underestimated in Brazil, will inform the design and implementation of future dengue vaccine trials. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | GlaxoSmithKline Brasil. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade do Estado do Amazonas. Boca do Acre, AM, Brasil. | |
| Affilliation | Centro de Pesquisas Clínicas de Natal. Natal, RN, Brasil. | |
| Affilliation | Universidade Estadual de Campinas. Campinas, SP, Brasil. | |
| Affilliation | Faculdade de Medicina e Odontologia São Leopoldo Mandic. Campinas, SP, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | GlaxoSmithKline Brasil. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | GlaxoSmithKline Brasil. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | GlaxoSmithKline Brasil. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | GlaxoSmithKline Belgium. Wavre, Belgium. | |
| Affilliation | GlaxoSmithKline Belgium. Wavre, Belgium. | |
| Affilliation | GlaxoSmithKline United States. Philadelphia, PA, United States. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | |
| Subject | Dengue | en_US |
| Subject | Incidence | en_US |
| Subject | Seroprevalence | en_US |
| Subject | Epidemiology | en_US |
| Subject | Multicentre cohort study | en_US |
| Subject | Brazil | en_US |
| DeCS | Reação em Cadeia da Polimerase | pt_BR |
