| Author | Balieiro, Antonio A. S. | |
| Author | Siqueira, Andre M. | |
| Author | Melo, Gisely C. | |
| Author | Monteiro, Wuelton M. | |
| Author | Sampaio, Vanderson S. | |
| Author | Mueller, Ivo | |
| Author | Lacerda, Marcus V. G. | |
| Author | Villela, Daniel A. M. | |
| Access date | 2021-06-24T12:48:37Z | |
| Available date | 2021-06-24T12:48:37Z | |
| Document date | 2021 | |
| Citation | BALIEIRO, Antonio A. S. et al. Short-Time Recurrences of Plasmodium vivax Malaria as a Public Health Proxy for Chloroquine-Resistance Surveillance: A Spatio-Temporal Study in the Brazilian Amazon. International journal of Environmental Research and Public Health, v. 18, n. 10, p. 1-11, May 2021. | pt_BR |
| ISSN | 1660-4601 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/47854 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Title | Short-Time Recurrences of Plasmodium vivax Malaria as a Public Health Proxy for Chloroquine-Resistance Surveillance: A Spatio-Temporal Study in the Brazilian Amazon | pt_BR |
| Type | Article | |
| DOI | 10.3390/ijerph18105061 | |
| Abstract | In Brazil, malaria caused by Plasmodium vivax presents control challenges due to several reasons, among them the increasing possibility of failure of P. vivax treatment due to chloroquine-resistance (CQR). Despite limited reports of CQR, more extensive studies on the actual magnitude of resistance are still needed. Short-time recurrences of malaria cases were analyzed in different transmission scenarios over three years (2005, 2010, and 2015), selected according to malaria incidence. Multilevel models (binomial) were used to evaluate association of short-time recurrences with variables such as age. The zero-inflated Poisson scan model (scanZIP) was used to detect spatial clusters of recurrences up to 28 days. Recurrences compose less than 5% of overall infection, being more frequent in the age group under four years. Recurrences slightly increased incidence. No fixed clusters were detected throughout the period, although there are clustering sites, spatially varying over the years. This is the most extensive analysis of short-time recurrences worldwide which addresses the occurrence of P. vivax CQR. As an important step forward in malaria elimination, policymakers should focus their efforts on young children, with an eventual shift in the first line of malaria treatment to P. vivax. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Manaus, AM, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biologia Parasitaria. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação de Medicina Tropical Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós Graduação em Medicina Tropical. Manaus, AM, Brasil. | pt_BR |
| Affilliation | Fundação de Medicina Tropical Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós Graduação em Medicina Tropical. Manaus, AM, Brasil. | pt_BR |
| Affilliation | Fundação de Medicina Tropical Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós Graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação de Vigilância em Saúde. Manaus, AM, Brasil. | pt_BR |
| Affilliation | Walter & Elisa Hall Institute. Melbourne, Australia / Pasteur Institute. Paris, France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Manaus, AM, Brasil / Fundação de Medicina Tropical Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós Graduação em Medicina Tropical. Manaus, AM, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biologia Parasitaria. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Plasmodium vivax | pt_BR |
| Subject | Chloroquine | pt_BR |
| Subject | Disease elimination | pt_BR |
| Subject | Malaria | pt_BR |
| Subject | Resistance | pt_BR |
