| Author | Gaitán-Albarracín, Felipe | |
| Author | Losada-Barragán, Monica | |
| Author | Pinho, Nathalia | |
| Author | Azevedo, Renata | |
| Author | Durães, Jonathan | |
| Author | Arcila-Barrera, Juan Sebástian | |
| Author | Menezes, Rodrigo C. | |
| Author | Morgado, Fernanda N. | |
| Author | Carvalho, Vinicius de Frias | |
| Author | Umaña-Pérez, Adriana | |
| Author | Cuervo, Patricia | |
| Access date | 2021-06-28T12:28:43Z | |
| Available date | 2021-06-28T12:28:43Z | |
| Document date | 2021 | |
| Citation | GAITÁN-ALBARRACIN, Felipe et al. Malnutrition Aggravates Alterations Observed in the Gut Structure and Immune Response of Mice Infected with Leishmania infantum. Microorganims, v. 9, p. 1-19, June 2021. | pt_BR |
| ISSN | 2076-2607 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/47890 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Leishmania infantum | pt_BR |
| Subject in Portuguese | Leishmaniose visceral | pt_BR |
| Subject in Portuguese | Má nutrição | pt_BR |
| Subject in Portuguese | Duodeno | pt_BR |
| Subject in Portuguese | Inflamação | pt_BR |
| Subject in Portuguese | IgA | pt_BR |
| Subject in Portuguese | Absorção Gastrointestinal | pt_BR |
| Title | Malnutrition aggravates alterations observed in the gut structure and immune response of mice infected with Leishmania infantum | pt_BR |
| Type | Article | |
| DOI | 10.3390/microorganisms9061270 | |
| Abstract | Malnutrition is a risk factor for developing visceral leishmaniasis and its severe forms. Our group demonstrated that malnourished animals infected with Leishmania infantum had severe atrophies in lymphoid organs and T cell subpopulations as well as altered levels of thymic and splenic chemotactic factors, all of which resulted in dysfunctional lymphoid microenvironments that promoted parasite proliferation. Here, we hypothesize that malnutrition preceding parasite infection leads to structural and immunological changes in the gut mucosae, resulting in a failure in the immune response sensed in the intestine. To evaluate this, we analyzed the immunopathological events resulting from protein malnutrition in the guts of BALB/c mice infected with L. infantum. We observed lymphocytic/lymphoplasmacytic inflammatory infiltrates and lymphoid hyperplasia in the duodenum of well-nourished-infected mice; such alterations were worsened when malnutrition pre ceded infection. Parasite infection induced a significant increase of duodenal immunoglobulin A (IgA) of well-nourished animals, but those levels were significantly decreased in malnourished-infected mice. In addition, increased levels of Th17-related cytokines in duodenums of malnourished animals supported local inflammation. Together, our results suggest that the gut plays a potential role in re sponses to L. infantum infection—and that such responses are impaired in malnourished individual. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmanioses. Rio de Janeiro, RJ, Brasil / Universidad Nacional de Colombia. Facultad de Ciencias. Departamento de Química. Grupo de Investigación en Hormonas. Bogotá, Colombia. | pt_BR |
| Affilliation | Universidad Antonio Nariño. Grupo de Investigación en Biología Celular y Funcional e Ingeniería de Biomoléculas. Bogotá, Colombia. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmanioses. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmanioses. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmanioses. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidad Nacional de Colombia. Facultad de Ciencias. Departamento de Química. Grupo de Investigación en Hormonas. Bogotá, Colombia. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmanioses. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidad Nacional de Colombia. Facultad de Ciencias. Departamento de Química. Grupo de Investigación en Hormonas. Bogotá, Colombia. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmanioses. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Leishmania infantum | pt_BR |
| Subject | Visceral leishmaniasis | pt_BR |
| Subject | Malnutrution | pt_BR |
| Subject | Gut | pt_BR |
| Subject | Duodenum | pt_BR |
| Subject | Inflammation | pt_BR |
| Subject | IgA | pt_BR |
| DeCS | Absorção Gastrointestinal | pt_BR |
| xmlui.metadata.dc.subject.ods | 02 Fome zero e agricultura sustentável | |
