| Author | Arriaga Gutiérrez, María Belen | |
| Author | Rocha, Michael Santos | |
| Author | Nogueira, Betânia | |
| Author | Nascimento, Vanessa | |
| Author | Pereira, Mariana Araújo | |
| Author | Souza, Alexandra B. | |
| Author | Andrade, Alice M. S. | |
| Author | Costa, Alysson G. | |
| Author | Silva, Adriano Gomes | |
| Author | Silva, Elisangela C. | |
| Author | Figueiredo, Marina C. | |
| Author | Turner, Megan M. | |
| Author | Durovni, Betina | |
| Author | Silva, José R. Lapa e | |
| Author | Kritski, Afrânio L. | |
| Author | Cavalcante, Solange | |
| Author | Rolla, Valeria C. | |
| Author | Santos, Marcelo Cordeiro | |
| Author | Sterling, Timothy R. | |
| Author | Andrade, Bruno de Bezerril | |
| Access date | 2021-06-29T12:19:12Z | |
| Available date | 2021-06-29T12:19:12Z | |
| Document date | 2021 | |
| Citation | ARRIAGA GUTIÉRREZ, María Belen et al. The Effect of Diabetes and Prediabetes on Mycobacterium tuberculosis Transmission to Close Contacts. Journal of Infectious Diseases, p. 1-26, 2021. | |
| ISSN | 0022-1899 | |
| URI | https://www.arca.fiocruz.br/handle/icict/47916 | |
| Description | For the RePORT Brazil consortium | en_US |
| Sponsorship | Departamento de Ciência e Tecnologia (DECIT) - Secretaria de Ciência e Tecnologia (SCTIE) – Ministério da Saúde (MS), Brazil [25029.000507/2013-07 to V.C.R.], and the National Institutes of Allergy and Infectious Diseases [U01-AI069923]. The study was partially supported by the ntramural esearch Program of the unda o swaldo ru and the Intramural Research Program of the Fundação José Silveira. The work of B.B.A. was also supported by a grant from NIH (U01AI115940). B.B.A., A. .K., . . . . are senior scientists from the onselho acional de Desenvolvimento ient fico e Tecnol gico ( P ). M.B.A. received a scholarship from unda o de Amparo Pes uisa do stado da Bahia ( AP B). M.A.P. received a research fellowship from the oordena o de Aperfei oamento de Pessoal de vel uperior ( AP , finance code 1). | |
| Language | eng | en_US |
| Publisher | Oxford University Press | |
| Later version | https://www.arca.fiocruz.br/handle/icict/63610 | |
| Rights | open access | |
| Subject in Portuguese | Diabetes Mellitus | pt_BR |
| Subject in Portuguese | Pré-diabetes | pt_BR |
| Subject in Portuguese | Risco | pt_BR |
| Subject in Portuguese | Tuberculose | pt_BR |
| Subject in Portuguese | Mycobacterium tuberculosis | pt_BR |
| Title | The Effect of Diabetes and Prediabetes on Mycobacterium tuberculosis Transmission to Close Contacts | en_US |
| Type | Preprint | |
| DOI | 10.1093/infdis/jiab264/6278117 | |
| Abstract | Background. It is unknown whether dysglycemia is associated with Mycobacterium tuberculosis transmission. Methods. We assessed epidemiological and clinical characteristics of patients with culture-confirmed pulmonary tuberculosis and their close contacts, enrolled in a multicenter prospective cohort in Brazil. Contacts were investigated at baseline and 6 months after enrollment. QuantiFERON positivity at baseline and conversion (from negative to positive at month 6) were compared between subgroups of contacts according to glycemic status of persons with tuberculosis (PWTB) as diabetes mellitus (DM) or prediabetes. Multivariable mixed-effects logistic regression models were performed to test independent associations with baseline QuantiFERON positive and QuantiFERON conversion. Results. There were 592 PWTB (153 DM, 141 prediabetes, 211 normoglycemic) and 1784 contacts, of whom 658 were QuantiFERON-positive at baseline and 106 converters. Multivariable analyses demonstrated that tuberculosis-prediabetes cases, acidfast bacilli-positive, pulmonary cavities, and living with someone who smoked were independently associated with QuantiFERON positive in contacts at baseline. DM, persistent cough, acid-fast bacilli-positive, and pulmonary cavities in tuberculosis source cases were associated with QuantiFERON conversion. Conclusions. Contacts of persons with pulmonary tuberculosis and dysglycemia were at increased risk of being QuantiFERON positive at baseline or month 6. Increased focus on such close contacts could improve tuberculosis control. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brazil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil. | |
| Affilliation | Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA Brazil / Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Salvador, BA, Brazil. | |
| Affilliation | Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil / Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Salvador, BA, Brazil. | |
| Affilliation | Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA Brazil / Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Salvador, BA, Brazil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brazil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brazil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil. | |
| Affilliation | Fundação Medicina Tropical Dr Heitor Vieira Dourado. Manaus, BA, Brazil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, BA, Brazil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brazil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA Brazil. | |
| Affilliation | Fundação Medicina Tropical Dr Heitor Vieira Dourado. Manaus, BA, Brazil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, BA, Brazil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacteriose. Rio de Janeiro, RJ, Brazil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil. | |
| Affilliation | Vanderbilt University School of Medicine. Division of Infectious Diseases, Department of Medicine. Nashville, Tennessee, USA. | |
| Affilliation | Vanderbilt University School of Medicine. Division of Infectious Diseases, Department of Medicine. Nashville, Tennessee, USA. | |
| Affilliation | Secretaria Municipal de Saúde do Rio de Janeiro. Clínica da Família Rinaldo Delamare Rocinha. Rio de Janeiro, RJ, Brazil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil. | |
| Affilliation | Secretaria Municipal de Saúde do Rio de Janeiro. Clínica da Família Rinaldo Delamare Rocinha. Rio de Janeiro, RJ, Brazil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacteriose. Rio de Janeiro, RJ, Brazil. | |
| Affilliation | Fundação Medicina Tropical Dr Heitor Vieira Dourado. Manaus, BA, Brazil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, BA, Brazil / Universidade Nilton Lins. Manaus, AM, Brazil. | |
| Affilliation | Vanderbilt University School of Medicine. Division of Infectious Diseases, Department of Medicine. Nashville, Tennessee, USA. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brazil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil / Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Salvador, BA, Brazil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brazil / Universidade Salvador. Curso de Medicina. Laureate University. Salvador, BA, Brazil. | |
| Subject | Diabetes | en_US |
| Subject | Prediabetes | en_US |
| Subject | Quantiferon | en_US |
| Subject | Interferon-gamma releasing assay | en_US |
| Subject | Mycobacterium tuberculosis | en_US |
