| Author | Rodrigues, Ana Carolina Borges da Cruz | pt_BR |
| Author | Costa, Rafaela G. A. | pt_BR |
| Author | Silva, Suellen L. R. | pt_BR |
| Author | Dias, Ingrid R. S. B. | pt_BR |
| Author | Dias, Rosane Borges | pt_BR |
| Author | Bezerra, Daniel Pereira | pt_BR |
| Access date | 2021-06-30T14:04:11Z | |
| Available date | 2021-06-30T14:04:11Z | |
| Document date | 2021 | |
| Citation | RODRIGUES, Ana Carolina Borges da Cruz et al. Cell signaling pathways as molecular targets to eliminate AML stem cells. Critical Reviews in Oncology/Hematology, v. 160, p. 1-22, Apr. 2021. | pt_BR |
| ISSN | 1040-8428 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/47928 | |
| Sponsorship | Fundação de Amparo à Pesquisa da Bahia (FAPESB, Brazil) | pt_BR |
| Sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Brazil) | pt_BR |
| Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil) | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Leucemia mielóide aguda | pt_BR |
| Subject in Portuguese | Transdução de Sinais | pt_BR |
| Subject in Portuguese | Células-tronco | pt_BR |
| Subject in Portuguese | Terapêutica | pt_BR |
| Title | Cell signaling pathways as molecular targets to eliminate AML stem cells | en_US |
| Type | Article | |
| DOI | 10.1016/j.critrevonc.2021.103277 | pt_BR |
| Abstract | Acute myeloid leukemia (AML) remains the most lethal of leukemias and a small population of cells called leukemic stem cells (LSCs) has been associated with disease relapses. Some cell signaling pathways play an important role in AML survival, proliferation and self-renewal properties and are abnormally activated or suppressed in LSCs. This includes the NF-κB, Wnt/β-catenin, Hedgehog, Notch, EGFR, JAK/STAT, PI3K/AKT/mTOR, TGF/SMAD and PPAR pathways. This review aimed to discuss these pathways as molecular targets for eliminating AML LSCs. Herein, inhibitors/activators of these pathways were summarized as a potential new anti-AML therapy capable of eliminating LSCs to guide future researches. The clinical use of cell signaling pathways data can be useful to enhance the anti-AML therapy. | en |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Subject | Acute myeloid leukemia | en |
| Subject | Cell signaling | en |
| Subject | Leukemic stem cells | en |
| Subject | Target therapy | en |
