| Author | Cubillos-Angulo, Juan Manuel | |
| Author | Fernandes, Catarina D. | |
| Author | Araújo, Davi N. | |
| Author | Carmo, Cristinna A. | |
| Author | Arriaga Gutiérrez, María Belen | |
| Author | Andrade, Bruno de Bezerril | |
| Access date | 2021-07-06T12:29:13Z | |
| Available date | 2021-07-06T12:29:13Z | |
| Document date | 2021 | |
| Citation | CUBILLOS-ANGULO, Juan Manuel et al. The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review. Systematic Reviews, 2021. | pt_BR |
| ISSN | 2046-4053 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/48004 | |
| Sponsorship | Research Program of the
Fundação Oswaldo Cruz, Brazil. BBA is a senior investigator of the Conselho
Nacional de Desenvolvimento Científico e Tecnológico (CNPq). JMC-A was supported by the Organization of American States–Partnerships Program for
Education and Training (OAS-PAEC), and his study was financed in part by
the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior–Brazil (CAPE
S)–Finance Code 001. MBA and CDF received research fellowships from the
Fundação de Amparo à Pesquisa da Bahia (FAPESB). DNA and CAC received
research fellowships from CNPq. | pt_BR |
| Language | eng | pt_BR |
| Publisher | BMC | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Mycobacterium tuberculosis | pt_BR |
| Subject in Portuguese | Polimorfismo de nucleotídeo único | pt_BR |
| Subject in Portuguese | Tuberculose | pt_BR |
| Subject in Portuguese | Revisão Sistemática | pt_BR |
| Title | The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1186/s13643-021-01729-y | |
| Abstract | Tuberculosis (TB) is still one of the leading causes of death worldwide. Genetic studies have pointed
to the relevance of the NOD2 and CD14 polymorphic alleles in association with the risk of diseases caused by
Mycobacterium tuberculosis (Mtb) infection.
Methods: A systematic review was performed on PubMed, EMBASE, Scientific Electronic Library Online (SciELO),
and Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs) to examine the association between
single nucleotide polymorphisms (SNP) and risk of Mtb diseases. Study quality was evaluated using the Newcastle-
Ottawa Quality Scale (NOQS), and the linkage disequilibrium was calculated for all SNPs using a webtool (Package
LDpop).
Results: Thirteen studies matched the selection criteria. Of those, 9 investigated CD14 SNPs, and 6 reported a
significant association between the T allele and TT genotypes of the rs2569190 SNP and increased risk of Mtb
diseases. The genotype CC was found to be protective against TB disease. Furthermore, in two studies, the CD14
rs2569191 SNP with the G allele was significantly associated with increased risk of Mtb diseases. Four studies
reported data uncovering the relationship between NOD2 SNPs and risk of Mtb diseases, with two reporting
significant associations of rs1861759 and rs7194886 and higher risk of Mtb diseases in a Chinese Han population.
Paradoxically, minor allele carriers (CG or GG) of rs2066842 and rs2066844 NOD2 SNPs were associated with lower
risk of Mtb diseases in African Americans.
Conclusions: The CD14 rs2569190 and rs2569191 polymorphisms may influence risk of Mtb diseases depending on
the allele. Furthermore, there is significant association between NOD2 SNPs rs1861759 and rs7194886 and augmented
risk of Mtb diseases, especially in persons of Chinese ethnicity. The referred polymorphisms of CD14 and NOD2 genes
likely play an important role in risk of Mtb diseases and pathology and may be affected by ethnicity. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Curso de Medicina. Salvador, BA, Brasil / Vanderbilt University School of Medicine. Division of Infectious Diseases. Department of Medicine. Nashville, TN, USA / University of Cape Town. Institute of Infectious Disease and Molecular Medicine. Wellcome Centre for Infectious Disease Research in Africa. Cape Town, South Africa. | pt_BR |
| Subject | NOD2 | pt_BR |
| Subject | CD14 | pt_BR |
| Subject | Single nucleotide polymorphism | pt_BR |
| Subject | Tuberculosis | pt_BR |
