| Author | Oliveira, Pablo Rafael Silveira | pt_BR |
| Author | Matos, Lorena Oliveira de | pt_BR |
| Author | Araujo, Nathalia Matta | pt_BR |
| Author | Sant Anna, Hanaísa P. | pt_BR |
| Author | Silva, Daniel Almeida da Silva e | pt_BR |
| Author | Damasceno, Andresa K. Andrade | pt_BR |
| Author | Carvalho, Luana Martins de | pt_BR |
| Author | Horta, Bernardo Lessa | pt_BR |
| Author | Costa, Maria Fernanda Lima | pt_BR |
| Author | Barreto, Mauricio Lima | pt_BR |
| Author | Wiers, Corinde E. | pt_BR |
| Author | Volkow, Nora D. | pt_BR |
| Author | Godard, Ana Lúcia Brunialti | pt_BR |
| Access date | 2021-07-15T12:02:07Z | |
| Available date | 2021-07-15T12:02:07Z | |
| Document date | 2021 | |
| Citation | OLIVEIRA, Pablo Rafael Silveira et al. LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations. Frontiers in Psychiatry, v. 12, n. 665257, p. 1-12, 31 May 2021. | pt_BR |
| ISSN | 1664-0640 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/48242 | |
| Sponsorship | Brazilian Ministry of Health (Departamento de Ciência e Tecnologia da Secretaria de Ciência, Tecnologia e Insumos estratégicos). | pt_BR |
| Sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES, Ministério da Educação, Brazil). | pt_BR |
| Sponsorship | Pró-Reitoria de Pesquisa (PRPq) and Pós-Graduação em Genética from the Universidade Federal de Minas Gerais (UFMG), Brazil. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Alcoolismo | pt_BR |
| Subject in Portuguese | Inquéritos e questionários | pt_BR |
| Subject in Portuguese | Polimorfismos | pt_BR |
| Subject in Portuguese | Patrimônio genético | pt_BR |
| Subject in Portuguese | Fatores de risco | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations | en |
| Type | Article | pt_BR |
| DOI | 10.3389/fpsyt.2021.665257 | pt_BR |
| Abstract | Background: Genetics influence the vulnerability to alcohol use disorders, and among the implicated genes, three previous studies have provided evidences for the involvement of LRRK2 in alcohol dependence (AD). LRRK2 expression is broadly dysregulated in postmortem brain from AD humans, as well as in the brain of mice with alcohol dependent-like behaviors and in a zebrafish model of alcohol preference. The aim of the present study was to evaluate the association of variants in the LRRK2 gene with AD in multiethnic populations from South and North America. Methods: Alcohol-screening questionnaires [such as CAGE and Alcohol Use Disorders Identification Test (AUDIT)] were used to determine individual risk of AD. Multivariate logistic regression analyses were done in three independent populations (898 individuals from Bambuí, Brazil; 3,015 individuals from Pelotas, Brazil; and 1,316 from the United States). Linkage disequilibrium and conditional analyses, as well as in silico functional analyses, were also conducted. Results: Four LRRK2 variants were significantly associated with AD in our discovery cohort (Bambuí): rs4768231, rs4767971, rs7307310, and rs1465527. Two of these variants (rs4768231 and rs4767971) were replicated in both Pelotas and US cohorts. The consistent association signal (at the LRRK2 locus) found in populations with different genetic backgrounds reinforces the relevance of our findings. Conclusion: Taken together, these results support the notion that genetic variants in the LRRK2 locus are risk factors for AD in humans. | en |
| Affilliation | Universidade Federal da Bahia. Instituto de Biologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | National Institutes of Health. National Institute on Alcohol Abuse and Alcoholism. Rockville, MD, United States. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Biologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil. | pt_BR |
| Affilliation | University of Illinois. Center for Alcohol Research in Epigenetics. Department of Psychiatry. Chicago, IL, United States. | pt_BR |
| Affilliation | Universidade Federal de Pelotas. Faculdade de Medicina. Programa de Pós-Graduação em Epidemiologia. Pelotas, RS, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil. | pt_BR |
| Affilliation | National Institutes of Health. National Institute on Alcohol Abuse and Alcoholism. Laboratory of Neuroimaging. Bethesda, MD, United States. | pt_BR |
| Affilliation | National Institutes of Health. National Institute on Alcohol Abuse and Alcoholism. Laboratory of Neuroimaging. Bethesda, MD, United States. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil. | pt_BR |
| Subject | Alcohol dependence | en |
| Subject | CAGE | en |
| Subject | Audit | en |
| Subject | LRRK2 | en |
| Subject | Polymorphisms | en |
| Subject | Multiethnic | en |
