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AutorMoreira, Daniele Corrêa
AutorSantos, Arethuza dos
AutorMenezes, Rodrigo C.
AutorMorgado, Fernanda N.
AutorBorba, Cintia M.
AutorFerreira, Joseli Oliveira
Fecha de acceso2021-07-15T14:58:29Z
Fecha de disponibilización2021-07-15T14:58:29Z
Fecha de publicación2021
ReferenciaMOREIRA, Danielly Corrêa et al. Skin Immune Response of Immunocompetent and Immunosuppressed C57BL/6 Mice After Experimental Subcutaneous Infection Caused by Purpureocillium lilacinum. Frontiers in Microbiology. v. 12, Article 615383, p. 1-10, June 2021.pt_BR
ISSN1664-302pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/48251
Idiomaengpt_BR
EditorFrontiers Mediapt_BR
Derechos de autoropen access
Palabras clave en PortuguésPurpureocillium lilacinumpt_BR
Palabras clave en PortuguésResposta imune da pelept_BR
Palabras clave en PortuguésModelo experimentalpt_BR
Palabras clave en PortuguésImunossupressãopt_BR
Palabras clave en PortuguésImunohistoquímicapt_BR
TítuloSkin Immune Response of Immunocompetent and Immunosuppressed C57BL/6 Mice After Experimental Subcutaneous Infection Caused by Purpureocillium lilacinumpt_BR
Tipo del documentoArticle
DOI10.3389/fmicb.2021.615383
Resumen en InglésHyalohyphomycosis is a fungal infection characterized by the presence of a hyaline mycelium in the host. It is caused by several agents, such as Purpureocillium lilacinum. Our study aimed to evaluate some cell subsets and inflammatory markers involved in the in situ immune response to subcutaneous hyalohyphomycosis by P. lilacinum in C57BL/6 murine models. The fungal isolate was inoculated in mice randomly distributed in immunocompetent/infected (CI) and immunosuppressed/infected (SI) groups. Mice were evaluated on days 1, 3, 5, and 7 after inoculation. Histopathological studies showed several lesions in the site of infection as well as the formation of multifocal and mixed inflammatory infiltrates, which differed between the CI and SI groups. This analysis also revealed conidia and hypha-like structures in subcutaneous tissues of mice of both groups. The immunohistochemical analysis showed lower percentages of macrophages and neutrophils in the SI group compared to those in the CI group. Moreover, the intensity of interleukin (IL)-1β and nitric oxide synthase 2 production by cells of immunosuppressed mice was discreet, compared to immunocompetent mice that ranged from moderate to intense over time. The quantitative interference of dexamethasone in the response to the fungus was also demonstrated. We concluded that our results can be useful not only to broaden the knowledge on P. lilacinum but also, based on this host–parasite relationship, to contribute to the understanding of the mechanisms of infection.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil..pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil..pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonose em Animais Domésticos. Rio de Janeiro, RJ, Brasil,pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.pt_BR
Palavras clave en InglêsPurpureocillium lilacinumpt_BR
Palavras clave en InglêsSkin immune responsept_BR
Palavras clave en InglêsExperimental modelpt_BR
Palavras clave en InglêsImmunosuppressionpt_BR
Palavras clave en InglêsImmunohistochemistrypt_BR


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