Author | Dias, Júlia Scaff Moreira | pt_BR |
Author | Martins, Felipe Terra | pt_BR |
Author | Araújo Neto, João Honorato de | pt_BR |
Author | Castellano, Eduardo Ernesto | pt_BR |
Author | Viana, Rommel Bezerra | pt_BR |
Author | Teixeira, Jéssica da Silva | pt_BR |
Author | Guimarães, Elisalva Teixeira | pt_BR |
Author | Soares, Milena Botelho Pereira | pt_BR |
Author | Barbosa, Marília Imaculada Frazão | pt_BR |
Author | Doriguetto, Antônio Carlos | pt_BR |
Access date | 2021-07-16T14:03:34Z | |
Available date | 2021-07-16T14:03:34Z | |
Document date | 2021 | |
Citation | DIAS, Júlia Scaff Moreira et al. Novel ruthenium(III) complexes with hydroxybenzophenones: experimental and theoretical characterization and in vitro leishmanicidal activity comparing complexes and ligands. New Journal of Chemistry, v. 45, n. 17, p. 7501-7515, 19 Feb. 2021. | pt_BR |
ISSN | 1144-0546 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/48257 | |
Sponsorship | FINEP (ref. 134/08) | pt_BR |
Sponsorship | CNPq (448723/2014-0; 308162/2015-3; 428475/2018-3) | pt_BR |
Sponsorship | CAPES (PNPD and MS grant – Finance Code 001) | pt_BR |
Sponsorship | FAPEMIG (APQ-00273-14; APQ-02486-14; PPM-00533-16; APQ-01835-18) | pt_BR |
Language | eng | pt_BR |
Publisher | Royal Society of Chemistry | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Rutênio | pt_BR |
Subject in Portuguese | Leishmania | pt_BR |
Subject in Portuguese | Macrófagos | pt_BR |
Subject in Portuguese | Raios X | pt_BR |
Title | Novel ruthenium(III) complexes with hydroxybenzophenones: experimental and theoretical characterization and in vitro leishmanicidal activity comparing complexes and ligands | en |
Type | Article | pt_BR |
DOI | 10.1039/d0nj06159j | pt_BR |
Abstract | In this study, novel ruthenium(III) complexes with hydroxybenzophenones with the general formula cis-[RuCl2(HB)(dppb)] were obtained, where HB = 2-hydroxy-4-(octyloxy)benzophenone (C1), 2-hydroxy4-methoxybenzophenone (C2), 2,20-dihydroxy-4,40-dimethoxybenzophenone (C3), 2,20-dihydroxy-4-methoxybenzophenone (C4), 2,4-dihydroxybenzophenone (C5), and 2,4,40-trihydroxybenzophenone (C6), and dppb = 1,4-bis(diphenylphosphine)butane. These compounds were characterized by elemental analysis, molar conductivity, cyclic voltammetry, infrared and UV-vis spectroscopy, and powder X-ray diffraction. The crystal structures of C2, C3, C4, and C5 were determined by single-crystal X-ray diffraction analysis which confirmed the bidentate coordination of the carbonyl and phenolate oxygens of HB with ruthenium(III). Additionally, the cis geometry and electronic transitions of C1–C6 were investigated using DFT calculations. Finally, the comparative activity against promastigote forms of L. amazonensis was made available for the ligands HB1–HB6 and C1–C6. The ligands significantly inhibited the proliferation of promastigote forms, confirming the results previously published by some of us. Unfortunately, their respective complexes showed no activity. It is important to emphasize that the leishmanicidal activity of 2,20-dihydroxy-4,40-dimethoxybenzophenone (HB3), 2,20-dihydroxy-4-methoxybenzophenone (HB4), and 2,4,40-trihydroxybenzophenone (HB6) ligands is reported here for the first time. Despite the fact that they were less active against promastigote forms when compared to amphotericin B, two of them (HB4 and HB6) were less cytotoxic to J774 macrophages. | en |
Affilliation | Universidade Federal de Alfenas. Instituto de Química. Alfenas, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Goiás. Instituto de Química. Goiânia, GO, Brasil. | pt_BR |
Affilliation | Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Instituto de Física de São Carlos. Departamento de Física e Informática. São Carlos, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal de Alfenas. Instituto de Química. Alfenas, MG, Brasil. | pt_BR |
Affilliation | Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | SENAI CIMATEC. Instituto SENAI de Sistemas Avançados de Saúde. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal de Alfenas. Instituto de Química. Alfenas, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Alfenas. Instituto de Química. Alfenas, MG, Brasil. | pt_BR |
Subject | Ruthenium | en |
Subject | Leishmaniasis | en |
Subject | Macrophages | en |
Subject | X-Rays | en |
e-ISSN | 1369-9261 | pt_BR |