| Author | Piedade, Juliana | |
| Author | Pereira, Gustavo | |
| Author | Guimarães, Lívia | |
| Author | Duarte, Joana | |
| Author | Victor, Lívia | |
| Author | Baldin, Caroline | |
| Author | Inacio, Cintia | |
| Author | Santos, Ricardo | |
| Author | Chaves, Úrsula | |
| Author | Nunes, Estevão P. | |
| Author | Grinsztejn, Beatriz | |
| Author | Veloso, Valdiléa G. | |
| Author | Fernandes, Flavia | |
| Author | Perazzo, Hugo | |
| Access date | 2021-07-27T23:52:31Z | |
| Available date | 2021-07-27T23:52:31Z | |
| Document date | 2021 | |
| Citation | PIEDADE, Juliana et al. Liver stiffness regression after sustained virological response by direct-acting antivirals reduces the risk of outcomes. Scientific reports, v. 11, n. 1, p. 1-10, 2021. | pt_BR |
| ISSN | 2045-2322 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/48378 | |
| Language | eng | pt_BR |
| Publisher | Nature | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Liver stiffness regression after sustained virological response by direct-acting antivirals reduces the risk of outcomes | pt_BR |
| Type | Article | |
| DOI | 10.1038/s41598-021-91099-1 | |
| Abstract | The role of liver stiffness measurement (LSM) after sustained virological response (SVR) in HCV patients treated by direct-acting antivirals (DAAs) remains unclear. We aimed to evaluate LSM regression value after SVR and to identify risk factors associated with liver related complications (LRC) or death. This retrospective study analyzed patients with LSM ≥ 10 kPa with LSM by transient elastography pre-DAAs and post-SVR. Patients with previous hepatic decompensation were excluded. Medical records were reviewed to identify primary outcomes. Kaplan-Meier curves and time-to-event Cox proportional-hazard models were performed. 456 patients [65% female, 62 years (IQR 57-68)] were included. During a follow-up of 2.3 years (IQR 1.6-2.7), 28 patients developed 37 outcomes [rate = 29.0 (95% CI 20.0-42.0) per 1000 person-years]. The cumulative incidence of outcomes was significantly lower in patients who regressed LSM ≥ 20% [3.4% (95% CI 1.8-7.0) vs. 9.0% (5.5-14.5), p = 0.028]. In a multivariate Cox-model [HR(95% CI)], male gender [HR = 3.00 (1.30-6.95), p = 0.010], baseline albumin < 3.5 mg/dL [HR = 4.49 (1.95-10.34), p < 0.001] and baseline unfavorable Baveno-VI [HR = 4.72 (1.32-16.83), p = 0.017] were independently associated and LSM regression ≥ 20% after SVR had a trend to reduce the risk of LRC or death [HR = 0.45 (0.21-1.02), p = 0.058]. The use of simple parameters before DAAs and repetition of LSM post-SVR can identify patients with different risks for severe outcome after HCV eradication. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Hospital Federal de Bonsucesso. Serviço de Hepatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Federal de Bonsucesso. Serviço de Hepatologia. Rio de Janeiro, RJ, Brasil / Universidade Estácio de Sá. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Federal de Bonsucesso. Serviço de Hepatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Federal de Bonsucesso. Serviço de Hepatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Federal de Bonsucesso. Serviço de Hepatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Federal de Bonsucesso. Serviço de Hepatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Federal de Bonsucesso. Serviço de Hepatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Liver stiffness measurement | pt_BR |
| Subject | Liver related complications | pt_BR |
| Subject | Direct-acting antivirals | pt_BR |
| Subject | Sustained virological response | pt_BR |
