| Author | Morgado, Sergio Mascarenhas | |
| Author | Vicente, Ana Carolina Paulo | |
| Access date | 2021-08-02T14:46:46Z | |
| Available date | 2021-08-02T14:46:46Z | |
| Document date | 2021 | |
| Citation | MORGADO, Sergio Mascarenhas; VICENTE, Ana Carolina Paulo. Comprehensive in silico survey of the Mycolicibacterium mobilome reveals an as yet underexplored diversity.Microbial Genomics, v. 7, 000533, 17 p, Feb. 2021. | pt_BR |
| ISSN | 2057-5888 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/48473 | |
| Language | eng | pt_BR |
| Publisher | Microbiology Society | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Mycolicibacterium mobilome | pt_BR |
| Subject in Portuguese | Levantamento in silico | pt_BR |
| Subject in Portuguese | Diversidade ainda pouco explorada | pt_BR |
| Title | Comprehensive in silico survey of the Mycolicibacterium mobilome reveals an as yet underexplored diversity | pt_BR |
| Type | Article | |
| DOI | 10.1099/mgen.0.000533 | |
| Abstract | The mobilome plays a crucial role in bacterial adaptation and is therefore a starting point to understand and establish the gene
flow occurring in the process of bacterial evolution. This is even more so if we consider that the mobilome of environmental
bacteria can be the reservoir of genes that may later appear in the clinic. Recently, new genera have been proposed in the family
Mycobacteriaceae, including the genus Mycolicibacterium, which encompasses dozens of species of agricultural, biotechnologi cal, clinical and ecological importance, being ubiquitous in several environments. The current scenario in the Mycobacteriaceae
mobilome has some bias because most of the characterized mycobacteriophages were isolated using a single host strain,
and the few plasmids reported mainly relate to the genus Mycobacterium. To fill in the gaps in these issues, we performed
a systematic in silico study of these mobile elements based on 242 available genomes of the genus Mycolicibacterium. The
analyses identified 156 putative plasmids (19 conjugative, 45 mobilizable and 92 non-mobilizable) and 566 prophages in 86
and 229 genomes, respectively. Moreover, a contig was characterized by resembling an actinomycete integrative and conjuga tive element (AICE). Within this diversity of mobile genetic elements, there is a pool of genes associated with several canonical
functions, in addition to adaptive traits, such as virulence and resistance to antibiotics and metals (mercury and arsenic). The
type-VII secretion system was a common feature in the predicted plasmids, being associated with genes encoding virulent pro teins (EsxA, EsxB, PE and PPE). In addition to the characterization of plasmids and prophages of the family Mycobacteriaceae,
this study showed an abundance of these genetic elements in a dozen species of the genus Mycolicibacterium. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Mycolicibacterium mobilome | pt_BR |
| Subject | Silico survey | pt_BR |
| Subject | Reveals | pt_BR |
| Subject | Yet underexplored diversity | pt_BR |
| xmlui.metadata.dc.subject.ods | 10 Redução das desigualdades | |
