| Author | Sousa Jr., Ivanildo P. | |
| Author | Santos, Flavia B. dos | |
| Author | Paula, Vanessa S. de | |
| Author | Vieira, Tuane C. R. G. | |
| Author | Dias, Helver G. | |
| Author | Barros, Caroline A. | |
| Author | Silva, Edson E. da | |
| Access date | 2021-08-20T14:38:19Z | |
| Available date | 2021-08-20T14:38:19Z | |
| Document date | 2021 | |
| Citation | SOUSA JR, Ivanildo et al. Viral and Prion Infections Associated with Central Nervous System Syndromes in Brazil. Viruses, v. 13, 1370, p. 1-32, July 2021. | pt_BR |
| ISSN | 1999-4915 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/48688 | |
| Sponsorship | This work was supported by the São Paulo Research Foundation, Brazil (grant numbers 2017/13981-0, 2018/09383-3, 2018/14389-0, 2018/00837-1, and 2019/24251–9); the Brazilian National Council for Scientific and Technological Development (grant number 302584/2015-3, 408338/2018-0); the Clarendon Scholarship; Department of Zoology,
University of Oxford; Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico (FUNCAP 01/2017-SUS/PPSUS-CE FUNCAPSESADecit/SCTIE); Wellcome Trust and Royal Society Sir Henry Dale Fellowship (grant number 204311/Z/16/Z); and the Network of Clinical and Applied Research into Chikungunya through funds from the Department of Science and Technology, Brazilian Ministry of Health. | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Enterovírus | pt_BR |
| Subject in Portuguese | Flavivírus | pt_BR |
| Subject in Portuguese | Alfavírus | pt_BR |
| Subject in Portuguese | Herpesvírus | pt_BR |
| Subject in Portuguese | Prion | pt_BR |
| Subject in Portuguese | Sistema nervoso central | pt_BR |
| Title | Viral and Prion Infections Associated with Central Nervous System Syndromes in Brazil | pt_BR |
| Type | Article | |
| DOI | 10.3390/v13071370 | |
| Abstract | Virus-induced infections of the central nervous system (CNS) are among the most serious
problems in public health and can be associated with high rates of morbidity and mortality, mainly in
low- and middle-income countries, where these manifestations have been neglected. Typically, herpes
simplex virus 1 and 2, varicella-zoster, and enterovirus are responsible for a high number of cases in
immunocompetent hosts, whereas other herpesviruses (for example, cytomegalovirus) are the most
common in immunocompromised individuals. Arboviruses have also been associated with outbreaks
with a high burden of neurological disorders, such as the Zika virus epidemic in Brazil. There is a
current lack of understanding in Brazil about the most common viruses involved in CNS infections.
In this review, we briefly summarize the most recent studies and findings associated with the CNS, in
addition to epidemiological data that provide extensive information on the circulation and diversity
of the most common neuro-invasive viruses in Brazil. We also highlight important aspects of the
prion-associated diseases. This review provides readers with better knowledge of virus-associated
CNS infections. A deeper understanding of these infections will support the improvement of the
current surveillance strategies to allow the timely monitoring of the emergence/re-emergence of
neurotropic viruses. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovirus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Instituto Nacional de Ciência e Tecnologia para Biologia Estrutural e Bioimagem. Programa de Biologia Estrutural,. Rio de Janeiro, RJ, Brasil / Instituto Federal do Rio de Janeiro. PMBqBM. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Instituto Nacional de Ciência e Tecnologia para Biologia Estrutural e Bioimagem. Programa de Biologia Estrutural,. Rio de Janeiro, RJ, Brasil / Instituto Federal do Rio de Janeiro. PMBqBM. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovirus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Enteroviruses | pt_BR |
| Subject | Flaviviruses | pt_BR |
| Subject | Alphaviruses | pt_BR |
| Subject | Herpesviruses | pt_BR |
| Subject | Prion | pt_BR |
| Subject | Central nervous system | pt_BR |
