| Author | Nonaka, Carolina Kymie Vasques | |
| Author | Gräf, Tiago | |
| Author | Barcia, Camila Araújo de Lorenzo | |
| Author | Costa, Vanessa Ferreira | |
| Author | Oliveira, Janderson Lopes de | |
| Author | Passos, Rogério da Hora | |
| Author | Bastos, Iasmin Nogueira | |
| Author | Santana, Maria Clara Brito de | |
| Author | Santos, Ian Marinho | |
| Author | Sousa, Karoline Almeida Felix de | |
| Author | Weber, Thamires Gomes Lopes | |
| Author | Siqueira, Isadora Cristina de | |
| Author | Rocha, Clarissa Araújo Gurgel | |
| Author | Mendes, Ana Verena Almeida | |
| Author | Souza, Bruno Solano de Freitas | |
| Access date | 2021-08-20T18:26:32Z | |
| Available date | 2021-08-20T18:26:32Z | |
| Document date | 2021 | |
| Citation | NONAKA, Carolina Kymie Vasques et al. SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, northeast Brazil, February 2021. International Journal of Infectious Diseases, p. 1-20, 2021. | |
| ISSN | 1201-9712 | |
| URI | https://www.arca.fiocruz.br/handle/icict/48692 | |
| Description | A Rede Genômica Fiocruz é formada por especialistas de todas as unidades da Fundação no país e de institutos parceiros que se empenham diariamente em gerar dados mais robustos sobre o comportamento do SARS-Cov-2 e contribuir para um melhor preparo do país no enfrentamento da pandemia em termos de diagnóstico mais precisos e vacinas eficazes. Saiba mais sobre a Rede Genômica Fiocruz em: http://www.genomahcov.fiocruz.br/ | pt_BR |
| Sponsorship | National Committee for Ethics on Research (CONEP; CAAE: 29496920.8.0000.5262, 46821621.5.0000.0048 and 3.980.128 /2020). | |
| Language | eng | en_US |
| Publisher | Elsevier | |
| Later version | https://www.arca.fiocruz.br/handle/icict/50679 | |
| Rights | open access | |
| Subject in Portuguese | COVID-19 | pt_BR |
| Subject in Portuguese | SARS-CoV-2 | pt_BR |
| Subject in Portuguese | Unidades de Terapia Intensiva | pt_BR |
| Subject in Portuguese | Pandemia | pt_BR |
| Subject in Portuguese | Rede Genômica Fiocruz | pt_BR |
| Subject in Portuguese | GENOMAHCOV | pt_BR |
| Title | SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, northeast Brazil, February 2021 (Preprint) | en_US |
| Type | Preprint | |
| DOI | 10.1016/j.ijid.2021.08.003 | |
| Abstract | To evaluate changes in COVID-19 patients' characteristics occurring after the emergence of the SARS-CoV-2 variant of concern (VOC) P.1 (Gamma) by comparing the clinical, demographic and laboratory profile of patients hospitalized during the first (May-July 2020) and second (December 2020 - February 2021) pandemic waves. Methods: Data was collected from records of COVID-19 patients (n=4164) admitted to a single hospital in Salvador, Northeast Brazil. SARS-CoV-2 genome sequencing was performed in nasopharyngeal swab samples from 12 patients with age < 60 years-old admitted to the intensive care units (ICU) in February 2021. Results: From June 2020 to February 2021, the median age of patients admitted in the ICU decreased from 66 to 58 years (p<0.05), accompanied by an increased proportion of patients without comorbidities (15.32% vs 32.20%, p<0.0001). A significant reduction in the Ct values of SARS-CoV-2 RT-PCR tests was observed in the second wave (p<0.0001). Sequencing analysis detected lineage Gamma in all 12 ICU patients sampled in February 2021. Conclusion: Our results demonstrated an increased proportion of younger adults without comorbidities with severe disease during the second COVID-19 wave, shortly after the confirmation of local Gamma circulation. | en_US |
| Affilliation | São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / D'Or Institute for Research and Education (IDOR). Salvador, BA, Brazil. | |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil. | |
| Affilliation | São Rafael Hospital. Department of Infectology. Salvador, BA, Brazil. | |
| Affilliation | São Rafael Hospital. Intensive Care Unit. Salvador, BA, Brazil. | |
| Affilliation | São Rafael Hospital. Intensive Care Unit. Salvador, BA, Brazil. | |
| Affilliation | São Rafael Hospital. Intensive Care Unit. Salvador, BA, Brazil. | |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil. | |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil. | |
| Affilliation | São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil. | |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil. | |
| Affilliation | São Rafael Hospital. Clinical Laboratory. Salvador, BA, Brazil. | |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil. | |
| Affilliation | São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil. | |
| Affilliation | São Rafael Hospital. Department of Infectology. Salvador, BA, Brazil. | |
| Affilliation | São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil. | |
| Subject | COVID-19 | en_US |
| Subject | SARS-CoV-2 | en_US |
| Subject | Intensive Care Units | en_US |
| Subject | Pandemic | en_US |
