| Author | Sarno, Alice | |
| Author | Daltro, Cleidiane Borges | |
| Author | Mendes, Carlos Mauricio Cardeal | |
| Author | Bessa, Theolis Costa Barbosa | |
| Access date | 2021-08-23T11:31:53Z | |
| Available date | 2021-08-23T11:31:53Z | |
| Document date | 2021 | |
| Citation | SARNO, Alice et al. Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysis. Revista da Sociedade Brasileira de Medicina Tropical, v. 54, p. 1-7, 2021. | pt_BR |
| ISSN | 0037-8682 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/48696 | |
| Sponsorship | National Scientific and Technological Research Council (CNPq) [grant number 158967, 2015] and Bahia’s State Foundation for Research Support (FAPESB) [grant number BOL2647, 2013]. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001 | pt_BR |
| Language | eng | pt_BR |
| Publisher | Sociedade Brasileira de Medicina Tropical | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Tuberculose | pt_BR |
| Subject in Portuguese | Vacinas | pt_BR |
| Subject in Portuguese | Mycobacterium bovis | pt_BR |
| Subject in Portuguese | Antígenos HLA | pt_BR |
| Subject in Portuguese | Histocompatibilidade | pt_BR |
| Subject in Portuguese | Imunogenicidade da Vacina | pt_BR |
| Subject in Portuguese | Cadeias HLA-DRB1 | pt_BR |
| Title | Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysis | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1590/0037-8682-0017-2021 | |
| Abstract | Introduction: Tuberculosis (TB) is the leading cause of death worldwide caused by a single infectious disease agent. Brazil, Russia, India, China, and South Africa (BRICS) account for more than half of the world’s TB cases. Bacillus Calmette-Guérin (BCG) remains the only vaccine available despite its variable efficacy. Promising antigen-based vaccines have been proposed as prophylactic
and/or immunotherapeutic approaches to boost BCG vaccination. Relevant antigens must interact with the range of human leukocyte antigen (HLA) molecules present in target populations; yet this information is currently not available. Methods: MEDLINE and EMBASE were systematically searched for articles published during 2013-2020 to measure the allelic frequencies of HLA-DRB1 in the BRICS. Results: In total, 67 articles involving 3,207,861 healthy individuals were included in the meta-analysis. HLA-DRB1 alleles
*03, *04, *07, *11, *13, and *15 were consistently identified at high frequencies across the BRICS, with a combined estimated frequency varying from 52% to 80%. HLA-DRB1 alleles *01, *08, *09, *10, *12, and *14 were found to be relevant in only one or two BRICS populations. Conclusions: By combining these alleles, it is possible to ensure at least 80% coverage throughout the BRICS populations. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Rede Brasileira de Pesquisas em Tuberculose. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Tuberculosis | pt_BR |
| Subject | Epitope-based vaccine | pt_BR |
| Subject | Rational vaccine design | pt_BR |
| Subject | Vaccine candidate | pt_BR |
| Subject | Major histocompatibility complex | pt_BR |
| Subject | Immunogenicity | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
