| Author | Lopez, Kattya | |
| Author | Arriaga Gutiérrez, María Belen | |
| Author | Aliaga, Juan G. | |
| Author | Barreda, Nadia M. | |
| Author | Sanabria, Oswaldo M. | |
| Author | Huang, Chuan-Chin | |
| Author | Zhang, Zibiao | |
| Author | La Guardia, Ruth Garcia de | |
| Author | Lecca, Leonid | |
| Author | Carvalho, Ana Cristina Calçada | |
| Author | Kritski, Afrânio L. | |
| Author | Calderon, Roger I. | |
| Access date | 2021-08-24T13:00:00Z | |
| Available date | 2021-08-24T13:00:00Z | |
| Document date | 2021 | |
| Citation | LOPEZ, Katia et al. Dysglycemia is associated with Mycobacterium tuberculosis lineages in tuberculosis patients of North Lima—Peru. Plos One, v. 16, n. 1, e0243184, 14 p, Jan. 2021. | pt_BR |
| ISSN | 1932-6203 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/48714 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Mycobacterium linhagens de tuberculose | pt_BR |
| Subject in Portuguese | Disglicemia | pt_BR |
| Subject in Portuguese | Pacientes | pt_BR |
| Subject in Portuguese | Tuberculose | pt_BR |
| Subject in Portuguese | Norte de Lima | pt_BR |
| Subject in Portuguese | Peru | pt_BR |
| Title | Dysglycemia is associated with Mycobacterium tuberculosis lineages in tuberculosis patients of North Lima—Peru | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pone.0243184 | |
| Abstract | This study was performed to investigate the role of dysglycemia on the genetic diversity of
Mycobacterium tuberculosis (MTB) among pulmonary tuberculosis (TB) patients to build
scientific evidence about the possible mechanisms of TB transmission. MTB isolates
obtained of patients affected by pulmonary tuberculosis from health care facilities of North
Lima—Peru, were analyzed using whole genome sequencing and 24-locus mycobacterial
interspersed repetitive-unit -variable-number tandem repeats (MIRU-VNTR). Subsequently,
clinical and epidemiological characteristics were associated with clustering, lineages and
comorbid conditions. The analysis carried out 112 pulmonary TB patients from various
health centers in North Lima, 17 (15%) had diabetes mellitus (DM) and 33 (29%) had pre diabetes (PDM). Latin American-Mediterranean, Haarlem and Beijing were the most fre quent MTB lineages found in those patients. Previous TB (adjusted odds ratio [aOR] = 3.65;
95%CI: 1.32–17.81), age (aOR = 1.12; 95%CI: 1.03–1.45) and Beijing lineage (aOR = 3.53;
95%CI: 1.08–13.2) were associated with TB-DM comorbidity. Alcoholism (aOR = 2.92; 95%
CI: 1.10–8.28), age (aOR = 1.05; 95%CI: 1.03–1.12) and Haarlem lineage (aOR = 2.54;
95%CI: 1.04–6.51) were associated with TB-PDM comorbidity. Beijing and Haarlem line ages were independently associated with TB-DM and TB-PDM comorbidities, respectively.
Although these findings may be surprising, we must be cautious to suggest that dysglycemia
could be associated with a highly clustering and predisposition of MTB lineages related to a
serious impact on the severity of TB disease, which requires further research. | pt_BR |
| Affilliation | Socios En Salud Sucursal Peru, Lima, Peru / Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos. Lima, Peru / Division of Rheumatology, Immunity and Inflammation. Brigham and Women’s Hospital, Harvard Medical School. Boston, Massachusetts, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Socios En Salud Sucursal Peru, Lima, Peru. | pt_BR |
| Affilliation | Socios En Salud Sucursal Peru, Lima, Peru. | pt_BR |
| Affilliation | Socios En Salud Sucursal Peru, Lima, Peru. | pt_BR |
| Affilliation | Division of Global Health Equity, Brigham and Women’s Hospita. Boston, Massachusetts, USA. | pt_BR |
| Affilliation | Department of Global Health and Social Medicine, Harvard Medical Schoo. Boston, Massachusetts, USA. | pt_BR |
| Affilliation | Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos. Lima, Peru. | pt_BR |
| Affilliation | Socios En Salud Sucursal Peru, Lima, Peru. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovacões em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Programa Acadêmico de Tuberculose. Rio de Janeiro, Rj, Brasil. | pt_BR |
| Affilliation | Socios En Salud Sucursal Peru, Lima, Peru / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Programa Acadêmico de Tuberculose. Rio de Janeiro, Rj, Brasil. | pt_BR |
| Subject | Mycobacterium tuberculosis lineages | pt_BR |
| Subject | Tuberculosis | pt_BR |
| Subject | Patients | pt_BR |
| Subject | Dysglycemia | pt_BR |
| Subject | North LIma | pt_BR |
| Subject | Peru | pt_BR |
