| Author | Vyas, Pooja | |
| Author | Mathad, Jyoti S | |
| Author | Leu, Cheng-Shiun | |
| Author | Naik, Shilpa | |
| Author | Alexander, Mallika | |
| Author | Pereira, Mariana Araujo | |
| Author | Kulkarni, Vandana | |
| Author | Deshpande, Prasad | |
| Author | Yadana, Su | |
| Author | Andrade, Bruno de Bezerril | |
| Author | Bhosale, Ramesh | |
| Author | Kumar, Pavan | |
| Author | Babu, Subash | |
| Author | Gupta, Amita | |
| Author | Shivakoti, Rupak | |
| Access date | 2021-08-31T11:55:35Z | |
| Available date | 2021-08-31T11:55:35Z | |
| Document date | 2021 | |
| Citation | VYAS, Pooja et al. Impact of HIV status on systemic inflammation during pregnancy Running Head: Inflammation in pregnant women with HIV. Current Microbiology, 2021. | |
| URI | https://www.arca.fiocruz.br/handle/icict/48851 | |
| Description | 1Department of Epidemiology, Columbia University Mailman School of Public Health, New York, USA 2Department of Medicine, Weill Cornell Medical College, New York, USA 3Department of Biostatistics, Columbia University Mailman School of Public Health, New York, USA 4Department of Obstetrics and Gynecology, Byramjee Jeejeebhoy Government Medical College, Pune, India 5Byramjee-Jeejeebhoy Government Medical college-Johns Hopkins University Clinical Research Site, Pune, India 6Instituto Goncalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil 7Multinational Organization Network Sponsoring Translational and Epidemiological Research, (MONSTER) Initiative, Salvador, Brazil 8Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Brazil 9Curso de Medicina, Faculdade de Tecnologia e Ciências, Salvador, Brazil 10Universidade Salvador (UNIFACS), Laureate Universities, Salvador, Brazil 11Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador, Brazil 12National Institutes of Health, National Institute for Research in Tuberculosis, International Center for Excellence in Research, Chennai, India 13Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA. | pt_BR |
| Sponsorship | Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health under award number R00HD089753 to RS and R01HD081929 to AG. JSM received support from NIAID (K23AI129854). Additional support for this work was the NIH-funded Johns Hopkins Baltimore-Washington-India Clinical Trials Unit for NIAID Networks (UM1AI069465 to AG). BBA is a senior investigator from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. MAP received a research fellowship from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES; finance code 001). | |
| Language | eng | en_US |
| Publisher | Springer | |
| Rights | open access | |
| Subject in Portuguese | Gravidez | pt_BR |
| Subject in Portuguese | Inflamação | pt_BR |
| Subject in Portuguese | HIV | pt_BR |
| Subject in Portuguese | Índia | pt_BR |
| Subject in Portuguese | Monócito | pt_BR |
| Title | Impact of HIV status on systemic inflammation during pregnancy Running Head: Inflammation in pregnant women with HIV | en_US |
| Type | Preprint | |
| Abstract | There are limited studies on the «association» of «HIV infection» with systemic «inflammation» during «pregnancy». Design: A «cohort study» (N=220) of «pregnant women» with «HIV» (N=70) (all on antiretroviral «therapy») and without «HIV» (N=150) were enrolled from an antenatal clinic in Pune, «India». «Methods»: The following systemic inflammatory markers were measured in «plasma» samples using «immunoassays»: soluble CD163 (sCD163), «soluble CD14» («sCD14»), intestinal fatty acidbinding «protein» (I-FABP), «C-reactive protein» (CRP), «alpha 1-acid glycoprotein» (AGP), «interferon»-β (IFNβ), «interferon»-γ (IFNγ), «interleukin» (IL)-1β, «IL-6», «IL-13», «IL-17A» and «tumor» «necrosis» factor α (TNFα). Generalized estimating equation (GEE) and «linear regression» models were used to assess the «association» of «HIV» status with each inflammatory marker during «pregnancy» and by trimester, respectively. Results: «Pregnant women» with «HIV» had higher levels of markers for gut «barrier» dysfunction (I-FABP), «monocyte» activation («sCD14») and markers of systemic «inflammation» («IL-6» and TNFα), but surprisingly lower levels of AGP, an «acute phase protein», compared to pregnant «women» without «HIV», with some trimester-specific differences. Conclusions: Our data show that «women» with «HIV» had higher levels of markers of gut «barrier» dysfunction, «monocyte» activation and systemic «inflammation». These markers, some of which are associated with «preterm birth», might help explain the increase in adverse «birth» outcomes in «women» with «HIV» and could suggest targets for potential interventions. | en_US |
| Affilliation | “Múltipla – ver em notas” | |
| Subject | Pregnancy | en_US |
| Subject | Inflammation | en_US |
| Subject | HIV | en_US |
| Subject | India | en_US |
| Subject | Monocyte | en_US |
