Access date | 2021-08-31T15:48:01Z | |
Available date | 2021-08-31T15:48:01Z | |
Document date | 2021 | |
Citation | SOUZA, Tatiana de Arruda Campos Brasil et al. Polypeptide with asparaginase activity, expression cassette, expression vector, host cell, pharmaceutical composition, methods for producing a polypeptide with asparaginase activity and for preventing or treating cancer, and use of a polypeptide. US Pat. 2021/0121544 A1, 29 abr. 2021. 31p. | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/48861 | |
Language | eng | pt_BR |
Publisher | United States Patent and Trademark Office | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Asparaginase | pt_BR |
Subject in Portuguese | Câncer | pt_BR |
Title | Polypeptide with Asparaginase Activity, Expression Cassette, Expression Vector, Host Cell, Pharmaceutical Composition, Methods for Producing a Polypeptide with Asparaginase Activity and for Preventing or Treating Cancer, and Use of a Polypeptide | pt_BR |
Type | Patent | pt_BR |
Abstract | The present invention refers to polypeptides with asparaginase activity that have an increased rate of self-processing compared to human wild L-asparaginase (ASRGL1), with mutation in the ASRGL1 glycine rich loop called HGG loop (Histidine 8-Glycine 9-Glycine 10). Polynucleotides that encode the polypeptides of invention are also described here, expression cassettes comprising so-called polynucleotides, expression vectors, host cells, pharmaceutical compositions, uses of the invention polypeptide in the manufacture of a preventive medicine or cancer treatment and methods to produce the polypeptide of invention and to prevent or treat cancer. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
Subject | Asparaginase | pt_BR |
Subject | Cancer | pt_BR |
Inventor | Souza, Tatiana de Arruda Campos Brasil de | pt_BR |
Inventor | Zanchin, Nilson Ivo Tonin | pt_BR |
Inventor | Morais, Stephanie Bath de | pt_BR |
Patent holder | Fundação Oswaldo Cruz | pt_BR |
IPC number | A61K 38/50 | |
IPC number | C12N 15/66 | |
IPC number | A61P 35/02 | |
Filling number | US16/963,173 | pt_BR |
Priority number | BR102018001033-6A2 | pt_BR |
Filing date | 2020-07-17 | |
Publication number | US2021/0121544A1 | pt_BR |
Country | Brasil | pt_BR |
Country | Organização Mundial para Propriedade Intelectual OMPI | pt_BR |
Country | China | pt_BR |
Country | Escritório de Patentes Europeu | pt_BR |
Country | Estados Unidos da América | pt_BR |
Country | Índia | pt_BR |
Country | Canadá | pt_BR |