| Access date | 2021-08-31T16:01:59Z | |
| Available date | 2021-08-31T16:01:59Z | |
| Document date | 2020 | |
| Citation | SOUZA, Tatiana de Arruda Campos Brasil et al. Polypeptide with asparaginase activity, expression cassette, expression vector, host cell, pharmaceutical composition, methods for producing a polypeptide with asparaginase activity and for preventing or treating cancer, and use of a polypeptide. EP Pat. 3741850 A1, 25 nov. 2020. 45p. | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/48862 | |
| Language | eng | pt_BR |
| Publisher | European Patent Office | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Asparaginase | pt_BR |
| Subject in Portuguese | Câncer | pt_BR |
| Title | Polypeptide with asparaginase activity, expression cassette, expression vector, host cell, pharmaceutical composition, methods for producing a polypeptide with asparaginase activity and for preventing or treating cancer, and use of a polypeptide | pt_BR |
| Alternative title | Polypeptid mit asparaginase-aktivität, expressionskassette, expressionsvektor, wirtszelle, pharmazeutische zusammensetzung, verfahren zur herstellung eines polypeptids mit asparaginase-aktivität und zur vorbeugung oder behandlung von krebs sowie verwendung eines polypeptids | pt_BR |
| Type | Patent | pt_BR |
| Abstract | The present invention refers to polypeptides with asparaginase activity that have an increased rate of self-processing compared to human wild L-asparaginase (ASRGL1), with mutation in the ASRGL1 glycine rich loop called HGG loop (Histidine 8-Glycine 9-Glycine 10). Polynucleotides that encode the polypeptides of invention are also described here, expression cassettes comprising so-called polynucleotides, expression vectors, host cells, pharmaceutical compositions, uses of the invention polypeptide in the manufacture of a preventive medicine or cancer treatment and methods to produce the polypeptide of invention and to prevent or treat cancer. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
| Subject | Asparaginase | pt_BR |
| Subject | Cancer | pt_BR |
| Inventor | Souza, Tatiana de Arruda Campos Brasil de | pt_BR |
| Inventor | Zanchin, Nilson Ivo Tonin | pt_BR |
| Inventor | Morais, Stephanie Bath de | pt_BR |
| Patent holder | Fundação Oswaldo Cruz | pt_BR |
| IPC number | C12N 9/82 | |
| IPC number | C12N 15/55 | |
| IPC number | A61P 35/00 | |
| IPC number | A61K 38/50 | |
| IPC number | C12N 15/66 | |
| IPC number | A61P 35/02 | |
| Filling number | EP19741242.2 | pt_BR |
| Priority number | BR102018001033-6A2 | pt_BR |
| Filing date | 2019-01-18 | |
| Publication number | EP3741850A1 | pt_BR |
| Country | Brasil | pt_BR |
| Country | Organização Mundial para Propriedade Intelectual OMPI | pt_BR |
| Country | China | pt_BR |
| Country | Escritório de Patentes Europeu | pt_BR |
| Country | Estados Unidos da América | pt_BR |
| Country | Índia | pt_BR |
| Country | Canadá | pt_BR |
