| Author | Soeiro, Maria de Nazare Correia | |
| Author | Vergoten, Gérard | |
| Author | Bailly, Christian | |
| Access date | 2021-09-02T14:54:57Z | |
| Available date | 2021-09-02T14:54:57Z | |
| Document date | 2021 | |
| Citation | SOEIRO, Maria de Nazaré Correia; VERGOTEN, Gérard; BAILLY, Christian. Mechanism of action of glycyrrhizin against Plasmodium falciparum. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e210084, 7 p, 2021. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/48916 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Malária | pt_BR |
| Subject in Portuguese | Plasmodium | pt_BR |
| Subject in Portuguese | Glyoxalase 1 | pt_BR |
| Subject in Portuguese | Glycyrrhizin | pt_BR |
| Subject in Portuguese | Colesterol | pt_BR |
| Title | Mechanism of action of glycyrrhizin against Plasmodium falciparum | pt_BR |
| Type | Article | |
| DOI | 10.1590/0074-02760210084 | |
| Abstract | Extracts of the plant Glycyrrhiza glabra (licorice) are used in traditional medicine to treat malaria. The main active
components are the saponin glycyrrhizin (GLR) and its active metabolite glycyrrhetinic acid (GA) which both display activities
against Plasmodium falciparum. We have identified three main mechanisms at the origin of their anti-plasmodial activity: (i)
drug-induced disorganisation of membrane lipid rafts, (ii) blockade of the alarmin protein HMGB1 and (iii) potential inhibition
of the detoxifying enzyme glyoxalase 1 (GLO-1) considered as an important drug target for malaria. Our analysis shed light on
the mechanism of action of GLR against P. falciparum. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of Lille. Inserm. Institut de Chimie Pharmaceutique Albert Lespagnol. Faculté de Pharmacie. Lille, France. | pt_BR |
| Affilliation | OncoWitan. Lille, France. | pt_BR |
| Subject | Cholesterol | pt_BR |
| Subject | Glycyrrhizin | pt_BR |
| Subject | Glyoxalase 1 | pt_BR |
| Subject | HMGB1, Malaria | pt_BR |
| Subject | Plasmodium | pt_BR |
| e-ISSN | 1678-8060 | |
