| Author | Gomes, Keyla Nunes Farias | |
| Author | Santos, José Augusto Albuquerque dos | |
| Author | Faria, Robson Xavier | |
| Access date | 2021-09-03T13:52:56Z | |
| Available date | 2021-09-03T13:52:56Z | |
| Document date | 2021 | |
| Citation | GOMES, Keyla Nunes Farias; SANTOS, José Augusto Albuquerque dos; FARIA, Robson Xavier. Aqueous Extracts: An Alternative in the Control of the Intermediate Host of Schistosomiasis. Open Access Journal of Biomedical Science, v. 4, n. 3, p. 1063-1065, 2021. | pt_BR |
| ISSN | 2690-487X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/48953 | |
| Language | eng | pt_BR |
| Publisher | Biomedscis | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Esquistossomose | pt_BR |
| Subject in Portuguese | Produtos naturais | pt_BR |
| Subject in Portuguese | Extratos aquosos | pt_BR |
| Subject in Portuguese | Atividade moluscicida | pt_BR |
| Subject in Portuguese | Moluscos | pt_BR |
| Title | Aqueous Extracts: An Alternative in the Control of the Intermediate Host of Schistosomiasis | pt_BR |
| Type | Article | |
| DOI | 10.38125/OAJBS.000302 | |
| Abstract | Schistosomiasis is a parasitic disease caused by worms of the genus Schistosoma. Some substances are used to control the
intermediate host, being a strategy to prevent the risk of infection and re-infection of the disease. According to the WHO, the
recommended substance is Niclosamide; however, it presents toxicity in non-target organisms. Aqueous extracts are being
increasingly studied as a potential molluscicide in combating schistosomiasis. The aqueous extract of Moringa oleifera flowers was
used to evaluate the molluscicidal activity in Biomphalaria glabrata. This extract caused lethality in adult molluscs, obtaining a
lethal concentration 50 = 2.37 mg/mL. In the second aqueous extract, fruits of the species Randia nilotica were used on molluscs
of the species Biomphalaria pfeifferi and Bulinus truncatus. These extracts showed molluscicidal activity on both molluscs used
in the experiments. In the third aqueous extract, they used leaves of the species Anagallis arvensis to test the molluscicidal action
on molluscs of the species Biomphalaria alexandrina. It was possible to obtain lethal concentrations, with lethal concentration 50
= 37.9 mg/L and lethal concentration 90 = 48.3 mg/L. In the fourth aqueous extract, they used the seeds of the species Moringa
oleifera to evaluate the molluscicidal activity in molluscs of the genus Bulinus. These seeds showed molluscicidal action, but they
were not in accordance with what is recommended by the WHO. According to the experiments carried out with aqueous extracts,
it can be seen that there are many studies using these methodologies as a form of control for schistosomiasis. Some criteria are
essential to obtain a low-cost aqueous extract. It is essential to emphasize that this methodology could be used by the government
to control the intermediate host of schistosomiasis in less favored areas, where the population itself would have access to inputs
using accessible technological resources. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Programa de Pós-graduação em Ciências e Biotecnologia. Instituto de Biologia. Campus Valonguinho, Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Programa de Pós-graduação em Ciências e Biotecnologia. Instituto de Biologia. Campus Valonguinho, Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxoplasmose e outras Protozoases. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Schistosomiasis | pt_BR |
| Subject | Natural products | pt_BR |
| Subject | Aqueous extracts | pt_BR |
| Subject | Molluscicide activity | pt_BR |
| Subject | Molluscs | pt_BR |
