| Author | Andrade, Laura Medeiros | |
| Author | Méio, Maria Dalva Barbosa Baker | |
| Author | Gomes Junior, Saint Clair dos Santos | |
| Author | Souza, Juliana Paiva | |
| Author | Figueiredo, Mirza R. | |
| Author | Costa, Roozemeria Pereira | |
| Author | Brasil, Patricia | |
| Author | Nielsen-Saines, Karin | |
| Author | Brickley, Elizabeth B. | |
| Author | Moreira, Maria Elisabeth Lopes | |
| Access date | 2021-09-06T19:46:38Z | |
| Available date | 2021-09-06T19:46:38Z | |
| Document date | 2020 | |
| Citation | ANDRADE, Laura Medeiros et al. Language delay was associated with a smaller head circumference at birth in asymptomatic infants prenatally exposed to the Zika virus. Acta Paediatrica, v. 110, n. 8, p. 2375-2381, Aug. 2021. | pt_BR |
| ISSN | 0001-6640 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/49012 | |
| Sponsorship | 205377/Z/16/Z/the United Kingdom's Department for International Development
R01 AI140718/AI/NIAID NIH HHS/United States
WT_/Wellcome Trust/United Kingdom | pt_BR |
| Language | eng | pt_BR |
| Publisher | Wiley [Commercial Publisher] Foundation, Acta Pædiatrica [Associate Organisation] | pt_BR |
| Rights | open access | pt_BR |
| MeSH | Female | pt_BR |
| MeSH | Humans | pt_BR |
| MeSH | Infant | pt_BR |
| MeSH | Infant, Newborn | pt_BR |
| MeSH | Language Development Disorders | pt_BR |
| MeSH | Microcephaly / etiology | pt_BR |
| MeSH | Pregnancy | pt_BR |
| MeSH | Pregnancy Complications, Infectious / diagnosis | pt_BR |
| MeSH | Zika Virus | pt_BR |
| MeSH | Zika Virus Infection / diagnosis | pt_BR |
| Title | Language delay was associated with a smaller head circumference at birth in asymptomatic infants prenatally exposed to the Zika virus | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1111/apa.15878 | |
| Abstract | Aim: Our aim was to analyse 12-month outcomes of children who were prenatally exposed to the Zika virus and asymptomatic at birth. Methods: This was an observational, exploratory study of infants exposed to the Zika virus during gestation and born between March 2016 and April 2017 without congenital Zika syndrome. They were followed until the age of 22 months. The outcome measure was neurodevelopment at 12 months of life, which was evaluated with the Bayley Scales of Infant and Toddler Development, Third edition (Bayley-III). The scores were adjusted for maternal education and prematurity. Results: A total of 96 infants were included in the study and 35.4% scored below the normal range in at least one Bayley-III domain. The majority (91.2%) of the infants with delayed scores presented with language delay, which was not associated with the gestational age at exposure. Receptive language was more affected by exposure than expressive language (27.0% vs 19.8%). There was a direct, and significant, association between the head circumference Z-score at birth and language delay. Conclusion: Language delay was associated with a smaller head circumference at birth in infants prenatally exposed to the Zika virus and born asymptomatic. This may indicate future learning difficulties. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of California Los Angeles. Los Angeles, CA, USA. | pt_BR |
| Affilliation | London School of Hygiene & Tropical Medicine. London, UK. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Zika virus | pt_BR |
| Subject | Children | pt_BR |
| Subject | Congenital infection | pt_BR |
| Subject | Language | pt_BR |
| Subject | Neurodevelopment. | pt_BR |
