| Author | Francelin, Carolina | |
| Author | Veneziani, Luciana Peixoto | |
| Author | Farias, Alessandro dos Santos | |
| Author | Cruz, Daniella Arêas Mendes da | |
| Author | Savino, Wilson | |
| Access date | 2021-09-12T19:32:40Z | |
| Available date | 2021-09-12T19:32:40Z | |
| Document date | 2021 | |
| Citation | FRANCELIN, Carolina et al. Neurotransmitters Modulate Intrathymic T-cell Development. Front. Cell Dev. Biol., v. 9, Article 668067, 7 p, Apr. 2021. | pt_BR |
| ISSN | 2296-634X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/49061 | |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Neurotransmissores | pt_BR |
| Subject in Portuguese | Timo | pt_BR |
| Subject in Portuguese | Células epiteliais teímicas | pt_BR |
| Subject in Portuguese | Desenvolvimento de células T | pt_BR |
| Subject in Portuguese | Timócitos | pt_BR |
| Title | Neurotransmitters Modulate Intrathymic T-cell Development | pt_BR |
| Type | Article | |
| DOI | 10.3389/fcell.2021.668067 | |
| Abstract | The existence of a crosstalk between the nervous and immune systems is well
established. Neurotransmitters can be produced by immune cells, whereas cytokines
can be secreted by cells of nervous tissues. Additionally, cells of both systems express
the corresponding receptors. Herein, we discuss the thymus as a paradigm for studies
on the neuroimmune network. The thymus is a primary lymphoid organ responsible for
the maturation of T lymphocytes. Intrathymic T-cell development is mostly controlled by
the thymic microenvironment, formed by thymic epithelial cells (TEC), dendritic cells,
macrophages, and fibroblasts. Developing thymocytes and microenvironmental cells
can be influenced by exogenous and endogenous stimuli; neurotransmitters are among
the endogenous molecules. Norepinephrine is secreted at nerve endings in the thymus,
but are also produced by thymic cells, being involved in controlling thymocyte death.
Thymocytes and TEC express acetylcholine receptors, but the cognate neurotransmitter
seems to be produced and released by lymphoid and microenvironmental cells, not by
nerve endings. Evidence indicates that, among others, TECs also produce serotonin and
dopamine, as well as somatostatin, substance P, vasoactive intestinal peptide (VIP) and
the typical pituitary neurohormones, oxytocin and arg-vasopressin. Although functional
data of these molecules in the thymus are scarce, they are likely involved in intrathymic T
cell development, as exemplified by somatostatin, which inhibits thymocyte proliferation,
differentiation, migration and cytokine production. Overall, intrathymic neuroimmune
interactions include various neurotransmitters, most of them of non-neuronal origin,
and that should be placed as further physiological players in the general process of
T-cell development. | pt_BR |
| Affilliation | Universidade de Campinas. Instituto de Biologia. Departamento de Genética, Microbiologia e Imunologia. Laboratório de Pesquisa Autoimune. Campinas, SP, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Imunomodulação. Rio de Janeiro, RJ, Brasil / University of Alabama at Birmingham. Department of Ophthalmology and Visual Sciences. Birmingham, AL, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Imunomodulação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o TImo. Rio de Janeiro, RJ, Brasil / Rede de Pesquisa em Neuroinflamação do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade de Campinas. Instituto de Biologia. Departamento de Genética, Microbiologia e Imunologia. Laboratório de Pesquisa Autoimune. Campinas, SP, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Imunomodulação. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Imunomodulação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o TImo. Rio de Janeiro, RJ, Brasil / Rede de Pesquisa em Neuroinflamação do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / School of Pharmacy and Biomedical Sciences, University of Central Lancashire. Preston, United Kingdom. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Imunomodulação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o TImo. Rio de Janeiro, RJ, Brasil / Rede de Pesquisa em Neuroinflamação do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Neurotransmitters | pt_BR |
| Subject | Thymus | pt_BR |
| Subject | Thymic epithelial cells | pt_BR |
| Subject | T-cell development | pt_BR |
| Subject | Thymocytes | pt_BR |
