| Author | Araujo, Oscar C. | |
| Author | Paua, Vanessa Salete de | |
| Author | Ó, Kycia M. do | |
| Author | Nogueira, Cristiane A. Villela | |
| Author | Araujo, Natalia M. | |
| Access date | 2021-09-17T12:54:24Z | |
| Available date | 2021-09-17T12:54:24Z | |
| Document date | 2021 | |
| Citation | ARAUJO, Oscar C. et al. Association of Polymorphisms in the Glutathione S-Transferase Theta-1 Gene with Cirrhosis and Hepatocellular Carcinoma in Brazilian Patients with Chronic Hepatitis C. Vaccines, v. 9, n. 831, 8 p, July 2021. | pt_BR |
| ISSN | 2076-393X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/49102 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Vírus da Hepatite C | pt_BR |
| Subject in Portuguese | Glutathione S-transferases | pt_BR |
| Subject in Portuguese | Cirrose | pt_BR |
| Subject in Portuguese | Carcinoma hepatocelular | pt_BR |
| Subject in Portuguese | Polimorfismos | pt_BR |
| Title | Association of Polymorphisms in the Glutathione S-Transferase Theta-1 Gene with Cirrhosis and Hepatocellular Carcinoma in Brazilian Patients with Chronic Hepatitis C | pt_BR |
| Type | Article | |
| DOI | 10.3390/vaccines9080831 | |
| Abstract | Abstract: Oxidative stress contributes to hepatitis C virus (HCV)–induced liver damage. Host genetic
factors may be involved in progression of HCV infection. The present study was conducted to
determine the influence of glutathione S-transferase (GST)-M1 and T1 gene polymorphisms during
different stages of HCV infection, including chronic hepatitis, cirrhosis, and hepatocellular carcinoma
(HCC). The study population comprised 190 patients (47 with chronic hepatitis, 83 with cirrhosis
(without HCC), and 60 with HCC). GSTM1 and GSTT1 gene polymorphisms were analyzed via
multiplex polymerase chain reaction. The GSTT1-null genotype was more commonly detected in
patients with cirrhosis (n = 17; 20.5%) and HCC (n = 13; 21.7%) than those with chronic hepatitis (n = 3;
6.4%). The differences in GSTT1-null genotype frequencies were significant for cirrhosis vs. chronic
hepatitis (odds ratio, OR, 3.778 (95% confidence interval, CI, 1.045–13.659); p = 0.043) and HCC vs.
chronic hepatitis (OR, 4.057 (95% CI, 1.083–15.201); p = 0.038) groups. However, the incidence of
individual GSTM1-null or combined GSTM1/GSTT1 double-null genotypes did not vary significantly
between the groups. Our collective findings support the utility of the GSTT1-null genotype as a
useful biomarker for liver disease progression in Brazilian patients with chronic hepatitis C. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital São Lucas. Petrópolis, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Hospital Universitário Clementino Fraga Filho. Divisão de Hepatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Hepatitis C virus | pt_BR |
| Subject | Glutathione S-transferases | pt_BR |
| Subject | Cirrhosis | pt_BR |
| Subject | Hepatocellular carcinoma | pt_BR |
| Subject | Polymorphisms | pt_BR |
