| Author | Magalhães, Nathalia Santos | |
| Author | Savino, Wilson | |
| Author | Silva, Patrícia Machado Rodrigues | |
| Author | Martins, Marco Aurélio | |
| Author | Carvalho, Vinícius Frias | |
| Access date | 2021-09-23T16:52:05Z | |
| Available date | 2021-09-23T16:52:05Z | |
| Document date | 2021 | |
| Citation | MAGALHÃES, Nathalia Santos et al. Gut Microbiota Dysbiosis is a Crucial Player for the Poor Outcomes for COVID-19 in Elderly, Diabetic and Hypertensive patients. Frontiers in Medicine, v. 8, Article 644751, Aug. 2021. | pt_BR |
| ISSN | 2298-858X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/49144 | |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | |
| Subject in Portuguese | COVID-19 | pt_BR |
| Subject in Portuguese | Envelhecimento | pt_BR |
| Subject in Portuguese | Diabetes | pt_BR |
| Subject in Portuguese | Microbiota intestinal | pt_BR |
| Subject in Portuguese | Hipertensão | pt_BR |
| Subject in Portuguese | SARS-CoV-2 | pt_BR |
| Title | Gut Microbiota Dysbiosis is a crucial player for the poor outcomes for COVID-19 in Rlderly, Diabetic and Hypertensive Patients | pt_BR |
| Type | Article | |
| DOI | 10.3389/fmed.2021.644751 | |
| Abstract | A new infectious disease, named COVID-19, caused by the coronavirus associated
to severe acute respiratory syndrome (SARS-CoV-2) has become pandemic in 2020.
The three most common pre-existing comorbidities associated with COVID-19-related
death are elderly, diabetic, and hypertensive people. A common factor among these
risk groups for the outcome of death in patients infected with SARS-CoV-2 is dysbiosis,
with an increase in the proportion of bacteria with a pro-inflammatory profile. Due to
this dysbiosis, elderly, diabetic, and hypertensive people present a higher propensity to
mount an inflammatory environment in the gut with poor immune editing, culminating in
a weakness of the intestinal permeability barrier and high bacterial product translocation
to the bloodstream. This scenario culminates in a low-grade, persistent, and systemic
inflammation. In this context, we propose here that high circulating levels of bacterial
products, like lipopolysaccharide (LPS), can potentiate the SARS-CoV-2-induced
cytokines, including IL-6, being crucial for development of the cytokine storm in the
severe form of the disease. A better understanding on the possible correlation between
gut dysbiosis and poor outcomes observed in elderly, diabetic, and hypertensive people
can be useful for the development of new therapeutic strategies based on modulation of
the gut microbiota. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz..Rede de Pesquisa em Neuroinflamação do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz..Rede de Pesquisa em Neuroinflamação do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz..Rede de Pesquisa em Neuroinflamação do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz..Rede de Pesquisa em Neuroinflamação do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | COVID-19 | pt_BR |
| Subject | Aging | pt_BR |
| Subject | Diabetes | pt_BR |
| Subject | Gut microbiota | pt_BR |
| Subject | Hypertension | pt_BR |
| Subject | SARS-CoV-2 | pt_BR |
