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| Autor | Oliveira, Marcia Pereira | |
| Autor | Prates, Janesly | |
| Autor | Gimenes, Alexandre Dantas | |
| Autor | Correa, Silvia Graciela | |
| Autor | Oliani, Sonia Maria | |
| Fecha de acceso | 2021-10-16T18:23:43Z | |
| Fecha de disponibilización | 2021-10-16T18:23:43Z | |
| Fecha de publicación | 2021 | |
| Referencia | OLIVEIRA, Marcia Pereira et al. Annexin A1 Mimetic Peptide Ac2-26 Modulates the Function of Murine Colonic and Human Mast Cells. Frontiers in Immunology, v. 12, Article 689484, p. 1-9, Sept. 2021 | pt_BR |
| ISSN | 1664-3224 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/49387 | |
| Idioma | eng | pt_BR |
| Editor | Frontiers Media | pt_BR |
| Derechos de autor | open access | |
| Palabras clave en Portugués | Mastócito | pt_BR |
| Palabras clave en Portugués | Composto 48/80 | pt_BR |
| Palabras clave en Portugués | Linha MC humana (HMC-1) | pt_BR |
| Palabras clave en Portugués | Cultura de explante de cólon | pt_BR |
| Palabras clave en Portugués | Anexina A1 | pt_BR |
| Palabras clave en Portugués | IL-4 | pt_BR |
| Título | Annexin A1 Mimetic Peptide Ac2-26 Modulates the Function of Murine Colonic and Human Mast Cells | pt_BR |
| Tipo del documento | Article | |
| DOI | 10.3389/fimmu.2021.689484 | |
| Resumen en Inglés | Mast cells (MCs) are main effector cells in allergic inflammation and after activation, they release stored (histamine, heparin, proteases) and newly synthesized (lipid mediators and cytokines) substances. In the gastrointestinal tract the largest MC population is located in the lamina propria and submucosa whereas several signals such as the cytokine IL-4, seem to increase the granule content and to stimulate a remarkable expansion of intestinal MCs. The broad range of MC-derived bioactive molecules may explain their involvement in many different allergic disorders of the gastrointestinal tract. Annexin A1 (AnxA1) is a 37 KDa glucocorticoid induced monomeric protein selectively distributed in certain tissues. Its activity can be reproduced by mimetic peptides of the N-terminal portion, such as Ac2-26, that share the same receptor FPR-L1. Although previous reports demonstrated that AnxA1 inhibits MC degranulation in murine models, the effects of exogenous peptide Ac2-26 on intestinal MCs or the biological functions of the Ac2-26/FPR2 system in human MCs have been poorly studied. To determine the effects of Ac2-26 on the function of MCs toward the possibility of AnxA1-based therapeutics, we treated WT and IL-4 knockout mice with peptide Ac2-26, and we examined the spontaneous and compound 48/80 stimulated colonic MC degranulation and cytokine production. Moreover, in vitro, using human mast cell line HMC-1 we demonstrated that exogenous AnxA1 peptide is capable of interfering with the HMC-1 degranulation in a direct pathway through formyl peptide receptors (FPRs). We envisage that our results can provide therapeutic strategies to reduce the release of MC mediators in inflammatory allergic processes. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliación | Universidade Estadual de São Paulo. Instituto de Biociências, Humanidades e Ciências Exatas. Departamento de Biologia. São José do Rio Preto, SP, Brasil. | pt_BR |
| Afiliación | Escola Faceres de Medicina. Departamento de Morfologia Funcional. São José do Rio Preto, SP, Brasil. | pt_BR |
| Afiliación | Departamento de Bioquímica Clinica-Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI - CONICET) - Facultad de Ciencias Quimicas - Universidad Nacional de Córdoba (UNC), Córdoba, Argentina. | pt_BR |
| Afiliación | Universidade Estadual de São Paulo. Instituto de Biociências, Humanidades e Ciências Exatas. Departamento de Biologia. São José do Rio Preto, SP, Brasil / Centro de Pesquisa Avançada em Medicina, CEPAM - Unilago. São José do Rio Preto, SP, Brasil / Universidade Federal de São Paulo. Escola Paulista de Medicina. Programa de Pós-Graduação em Estrutural e Biologia Funcional. São Paulo, SP, Brasil. | pt_BR |
| Palavras clave en Inglês | Mast cell (MC) | pt_BR |
| Palavras clave en Inglês | Compound 48/80 | pt_BR |
| Palavras clave en Inglês | Human MC line (HMC-1) | pt_BR |
| Palavras clave en Inglês | Colon explant culture | pt_BR |
| Palavras clave en Inglês | Annexin A1 | pt_BR |
| Palavras clave en Inglês | IL-4 | pt_BR |
| Palavras clave en Inglês | FPRs | pt_BR |
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