Author | Lu, Ye | |
Author | Corradi, Chiara | |
Author | Gentiluomo, Manuel | |
Author | Maturana, Evangelina López de | |
Author | Theodoropoulos, George E. | |
Author | Roth, Susanne | |
Author | Maiello, Evaristo | |
Author | Morelli, Luca | |
Author | Archibugi, Livia | |
Author | Izbicki, Jakob R. | |
Author | Sarlós, Patricia | |
Author | Kiudelis, Vytautas | |
Author | Oliverius, Martin | |
Author | Aoki, Mateus Nóbrega | |
Author | Vashist, Yogesh | |
Author | Eijck, Casper H. J. van | |
Author | Gazouli, Maria | |
Author | Talar-Wojnarowska, Renata | |
Author | Mambrini, Andrea | |
Author | Pezzilli, Raffaele | |
Author | Bueno-de-Mesquita, Bas | |
Author | Hegyi, Péter | |
Author | Souček, Pavel | |
Author | Neoptolemos, John P. | |
Author | Franco, Gregorio Di | |
Author | Sperti, Cosimo | |
Author | Kauffmann, Emanuele F. | |
Author | Hlaváč, Viktor | |
Author | Ermini, Stefano | |
Author | Małecka-Panas, Ewa | |
Author | Lucchesi, Maurizio | |
Author | Vanella, Giuseppe | |
Author | Dijk, Frederike | |
Author | Mohelníková-Duchoňová, Beatrice | |
Author | Bambi, Franco | |
Author | Petrone, Maria Chiara | |
Author | Jamroziak, Krzysztof | |
Author | Guo, Feng | |
Author | Kolarova, Katerina | |
Author | Capretti, Giovanni | |
Author | Milanetto, Anna Caterina | |
Author | Ginocchi, Laura | |
Author | Loveček, Martin | |
Author | Puzzono, Marta | |
Author | Laarhoven, Hanneke W. M. van | |
Author | Carrara, Silvia | |
Author | Ivanauskas, Audrius | |
Author | Papiris, Konstantinos | |
Author | Basso, Daniela | |
Author | Arcidiacono, Paolo G. | |
Author | Izbéki, Ferenc | |
Author | Chammas, Roger | |
Author | Vodicka, Pavel | |
Author | Hackert, Thilo | |
Author | Pasquali, Claudio | |
Author | Piredda, Maria L. | |
Author | Costello-Goldring, Eithne | |
Author | Cavestro, Giulia Martina | |
Author | Szentesi, Andrea | |
Author | Tavano, Francesca | |
Author | Włodarczyk, Barbara | |
Author | Brenner, Hermann | |
Author | Kreivenaite, Edita | |
Author | Gao, Xin | |
Author | Bunduc, Stefania | |
Author | Vermeulen, Roel C. H. | |
Author | Schneider, Martin A. | |
Author | Latiano, Anna | |
Author | Gioffreda, Domenica | |
Author | Testoni, Sabrina G. G. | |
Author | Kupcinskas, Juozas | |
Author | Lawlor, Rita T. | |
Author | Capurso, Gabriele | |
Author | Malats, Núria | |
Author | Campa, Daniele | |
Author | Canzian, Federico | |
Access date | 2021-11-11T18:11:07Z | |
Available date | 2021-11-11T18:11:07Z | |
Document date | 2021 | |
Citation | LU, Ye et al. Association of genetic variants affecting microRNAs and pancreatic cancer risk. Frontiers in Genetics. v. 12, n. 693933, p. 1–11, 2021. | pt_BR |
ISSN | 1664-8021 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/49779 | |
Language | por | pt_BR |
Publisher | Frontiers Media | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Câncer Pancreático | pt_BR |
Subject in Portuguese | miRNA | pt_BR |
Title | Association of genetic variants affecting microRNAs and pancreatic cancer risk | pt_BR |
Type | Article | pt_BR |
DOI | 10.3389/fgene.2021.693933 | |
Abstract | Genetic factors play an important role in the susceptibility to pancreatic cancer (PC). However, established loci explain a small proportion of genetic heritability for PC; therefore, more progress is needed to find the missing ones. We aimed at identifying single nucleotide polymorphisms (SNPs) affecting PC risk through effects on micro-RNA (miRNA) function. We searched in silico the genome for SNPs in miRNA seed sequences or 3 prime untranslated regions (3'UTRs) of miRNA target genes. Genome-wide association data of PC cases and
controls from the Pancreatic Cancer Cohort (PanScan) Consortium and the Pancreatic Cancer Case–Control (PanC4) Consortium were re-analyzed for discovery, and genotyping data from two additional consortia (PanGenEU and PANDoRA) were used for replication, for a total of 14,062 cases and 11,261 controls. None of the SNPs reached genome-wide significance in the meta-analysis, but for three of them the associations were in the same direction in all the study populations and showed lower value of p in the meta-analyses than
in the discovery phase. Specifically, rs7985480 was consistently associated with PC risk (OR = 1.12, 95% CI 1.07–1.17, p = 3.03 × 10−6 in the meta-analysis). This SNP is in linkage disequilibrium (LD) with rs2274048, which modulates binding of various miRNAs to the 3'UTR of UCHL3, a gene involved in PC progression. In conclusion, our results expand the knowledge of the genetic PC risk through miRNA-related SNPs and show the usefulness of functional prioritization to identify genetic polymorphisms associated with PC risk. | pt_BR |
Affilliation | Genomic Epidemiology Group. German Cancer Research Center (DKFZ). Heidelberg, Germany. / Medical Faculty Heidelberg. University of Heidelberg. Heidelberg, Germany. | pt_BR |
Affilliation | Department of Biology. University of Pisa. Pisa, Italy. | pt_BR |
Affilliation | Department of Biology. University of Pisa. Pisa, Italy. | pt_BR |
Affilliation | Genetic and Molecular Epidemiology Group. Spanish National Cancer Research Centre (CNIO). Madrid, Spain. | pt_BR |
Affilliation | First Propaedeutic University Surgery Clinic. Hippocratio General Hospital. Medical School. National and Kapodistrian University of Athens. Athens, Greece. | pt_BR |
Affilliation | Department of General Surgery. University of Heidelberg. Heidelberg, Germany. | pt_BR |
Affilliation | Department of Oncology. Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital. San Giovanni Rotondo, Italy. | pt_BR |
Affilliation | General Surgery. Department of Translational Research and New Technologies in Medicine and Surgery. University of Pisa, Pisa, Italy. | pt_BR |
Affilliation | Digestive and Liver Disease Unit. Sant’Andrea Hospita. Rome, Italy. / Faculty of Medicine and Psychology. Sapienza University of Rome. Rome, Italy. / Pancreato-Biliary Endoscopy and Endosonography Division. Pancreas Translational and Clinical Research Center. IRSSC San Raffaele Scientific Institute. Milan, Italy. | pt_BR |
Affilliation | Department of General. Visceral and Thoracic Surgery. University Medical Center Hamburg-Eppendorf. Hamburg, Germany. | pt_BR |
Affilliation | First Department of Medicine. Medical School. University of Pécs. Pécs, Hungary. | pt_BR |
Affilliation | Department of Gastroenterology. Institute for Digestive Research. Medical Academy. Lithuanian University of Health Sciences. Kaunas, Lithuania. | pt_BR |
Affilliation | Department of Surgery. Faculty Hospital Kralovske Vinohrady and Third Faculty of Medicine. Charles University. Prague, Czechia. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Department of General. Visceral and Thoracic Surgery. University Medical Center Hamburg-Eppendorf. Hamburg, Germany. | pt_BR |
Affilliation | Department of Surgery. Erasmus Medical Center. Erasmus University. Rotterdam, Netherlands. | pt_BR |
Affilliation | Laboratory of Biology. Medical School. National and Kapodistrian University of Athens. Athens, Greece. | pt_BR |
Affilliation | Department of Digestive Tract Diseases. Medical University of Lodz. Lodz, Poland. | pt_BR |
Affilliation | Oncological Department. Azienda USL Toscana Nord Ovest. Oncological Unit of Massa Carrara. Carrara, Italy. | pt_BR |
Affilliation | Department of Gastroenterology. San Carlo Hospital. Potenza, Italy. | pt_BR |
Affilliation | Department for Determinants of Chronic Diseases (DCD). National Institute for Public Health and the Environment (RIVM). Bilthoven, Netherlands. | pt_BR |
Affilliation | Institute for Translational Medicine. Medical School. University of Pécs. Pécs, Hungary. / Department of Medicine. Centre for Translational Medicine. University of Szeged. Szeged, Hungary. | pt_BR |
Affilliation | Biomedical Center. Faculty of Medicine in Pilsen. Charles University. Pilsen, Czechia. | pt_BR |
Affilliation | Department of General Surgery. University of Heidelberg. Heidelberg, Germany. | pt_BR |
Affilliation | General Surgery. Department of Translational Research and New Technologies in Medicine and Surgery. University of Pisa, Pisa, Italy. | pt_BR |
Affilliation | Department of Surgery-DiSCOG. Padua University Hospital. Padua, Italy. | pt_BR |
Affilliation | Division of General and Transplant Surgery. University of Pisa. Pisa, Italy. | pt_BR |
Affilliation | Biomedical Center. Faculty of Medicine in Pilsen. Charles University. Pilsen, Czechia. | pt_BR |
Affilliation | Department of General. Visceral and Thoracic Surgery. University Medical Center Hamburg-Eppendorf. Hamburg, Germany. | pt_BR |
Affilliation | Blood Transfusion Service. Azienda Ospedaliero-Universitaria Meyer. Children's Hospital. Florence, Italy. | pt_BR |
Affilliation | Department of Digestive Tract Diseases. Medical University of Lodz. Lodz, Poland. | pt_BR |
Affilliation | Oncological Department. Azienda USL Toscana Nord Ovest. Oncological Unit of Massa Carrara. Carrara, Italy. | pt_BR |
Affilliation | Digestive and Liver Disease Unit. Sant’Andrea Hospita. Rome, Italy. / Faculty of Medicine and Psychology. Sapienza University of Rome. Rome, Italy. / Pancreato-Biliary Endoscopy and Endosonography Division. Pancreas Translational and Clinical Research Center. IRSSC San Raffaele Scientific Institute. Milan, Italy. | pt_BR |
Affilliation | Department of Pathology. Cancer Center Amsterdam. Amsterdam University Medical Centers. University of Amsterdam. Amsterdam, Netherlands. | pt_BR |
Affilliation | Department of Oncology. Faculty of Medicine and Dentistry. Palacky University Olomouc and University Hospital Olomouc. Olomouc, Czechia. | pt_BR |
Affilliation | Blood Transfusion Service. Azienda Ospedaliero-Universitaria Meyer. Children's Hospital. Florence, Italy. | pt_BR |
Affilliation | Pancreato-Biliary Endoscopy and Endosonography Division. Pancreas Translational and Clinical Research Center. IRSSC San Raffaele Scientific Institute. Milan, Italy. | pt_BR |
Affilliation | Department of Hematology. Institute of Hematology and Transfusion Medicine. Warsaw, Poland. | pt_BR |
Affilliation | Medical Faculty Heidelberg. University of Heidelberg. Heidelberg, Germany. / Division of Clinical Epidemiology and Aging Research. German Cancer Research Center (DKFZ). Heidelberg, Germany. | pt_BR |
Affilliation | Department of Oncology. Faculty of Medicine and Dentistry. Palacky University Olomouc and University Hospital Olomouc. Olomouc, Czechia. | pt_BR |
Affilliation | Department of Biomedical Sciences. Humanitas University. Milan, Italy. / Pancreatic Surgery Unit. Humanitas Clinical and Research Center IRCCS. Milan, Italy. | pt_BR |
Affilliation | Department of Surgery-DiSCOG. Padua University Hospital. Padua, Italy. | pt_BR |
Affilliation | Oncological Department. Azienda USL Toscana Nord Ovest. Oncological Unit of Massa Carrara. Carrara, Italy. | pt_BR |
Affilliation | Department of Surgery I, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc. Olomouc, Czechia. | pt_BR |
Affilliation | Division of Experimental Oncology. Gastroenterology and Gastrointestinal Endoscopy Unit. Vita-Salute San Raffaele University. IRCCS San Raffaele Scientific Institute. Milan, Italy. | pt_BR |
Affilliation | Department of Medical Oncology. Cancer Center Amsterdam. Amsterdam University Medical Center. University of Amsterdam. Amsterdam, Netherlands. | pt_BR |
Affilliation | Division of Gastroenterology and Digestive Endoscopy. Department of Gastroenterology. Humanitas Clinical and Research Center IRCCS. Milan, Italy. | pt_BR |
Affilliation | Department of Gastroenterology. Institute for Digestive Research. Medical Academy. Lithuanian University of Health Sciences. Kaunas, Lithuania. | pt_BR |
Affilliation | Endoscopic Surgery Department. Hippocratio General Hospital of Athens. Athens, Greece. | pt_BR |
Affilliation | Department of Medicine – DIMED. Padua University Hospital. Padua, Italy. | pt_BR |
Affilliation | Pancreato-Biliary Endoscopy and Endosonography Division. Pancreas Translational and Clinical Research Center. IRSSC San Raffaele Scientific Institute. Milan, Italy. | pt_BR |
Affilliation | Szent György University. Teaching Hospital of County Fejér. Székesfehérvár, Hungary. | pt_BR |
Affilliation | Department of Radiology and Oncology. Institute of Cancer of São Paulo. São Paulo, Brazil. / Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Department of Molecular Biology of Cancer. Institute of Experimental Medicine of the Czech Academy of Sciences. Prague, Czechia. / Biomedical Center and Department of Surgery. Faculty of Medicine in Pilsen. Charles University. Pilsen, Czechia. / First Faculty of Medicine. Institute of Biology and Medical Genetics. Charles University. Prague, Czechia. | pt_BR |
Affilliation | Department of General Surgery. University of Heidelberg. Heidelberg, Germany. | pt_BR |
Affilliation | Department of Surgery-DiSCOG. Padua University Hospital. Padua, Italy. | pt_BR |
Affilliation | ARC-NET, Center for Applied Research on Cancer. University and Hospital Trust of Verona. Verona, Italy. | pt_BR |
Affilliation | Department of Molecular and Clinical Cancer Medicine. University of Liverpool. Liverpool, United Kingdom. | pt_BR |
Affilliation | Division of Experimental Oncology. Gastroenterology and Gastrointestinal Endoscopy Unit. Vita-Salute San Raffaele University. IRCCS San Raffaele Scientific Institute. Milan, Italy. | pt_BR |
Affilliation | Institute for Translational Medicine. Medical School. University of Pécs. Pécs, Hungary. / Department of Medicine. Centre for Translational Medicine. University of Szeged. Szeged, Hungary. | pt_BR |
Affilliation | Division of Gastroenterology and Research Laboratory. Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital. San Giovanni Rotondo, Italy. | pt_BR |
Affilliation | Department of Digestive Tract Diseases. Medical University of Lodz. Lodz, Poland. | pt_BR |
Affilliation | Division of Clinical Epidemiology and Aging Research. German Cancer Research Center (DKFZ). Heidelberg, Germany. / Division of Preventive Oncology. German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT). Heidelberg, Germany. / German Cancer Consortium (DKTK). German Cancer Research Center (DKFZ). Heidelberg, Germany. | pt_BR |
Affilliation | Department of Gastroenterology. Institute for Digestive Research. Medical Academy. Lithuanian University of Health Sciences. Kaunas, Lithuania. | pt_BR |
Affilliation | Division of Clinical Epidemiology and Aging Research. German Cancer Research Center (DKFZ). Heidelberg, Germany. / German Cancer Consortium (DKTK). German Cancer Research Center (DKFZ). Heidelberg, Germany. | pt_BR |
Affilliation | Institute for Translational Medicine. Medical School. University of Pécs. Pécs, Hungary. / Fundeni Clinical Institute. Bucharest, Romania. | pt_BR |
Affilliation | Institute for Risk Assessment Sciences (IRAS). Utrecht University. Utrecht, Netherlands. | pt_BR |
Affilliation | Department of General Surgery. University of Heidelberg. Heidelberg, Germany. | pt_BR |
Affilliation | Division of Gastroenterology and Research Laboratory. Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital. San Giovanni Rotondo, Italy. | pt_BR |
Affilliation | Division of Gastroenterology and Research Laboratory. Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital. San Giovanni Rotondo, Italy. | pt_BR |
Affilliation | Pancreato-Biliary Endoscopy and Endosonography Division. Pancreas Translational and Clinical Research Center. IRSSC San Raffaele Scientific Institute. Milan, Italy. | pt_BR |
Affilliation | Department of Gastroenterology. Institute for Digestive Research. Medical Academy. Lithuanian University of Health Sciences. Kaunas, Lithuania. | pt_BR |
Affilliation | ARC-NET, Center for Applied Research on Cancer. University and Hospital Trust of Verona. Verona, Italy. | pt_BR |
Affilliation | Digestive and Liver Disease Unit. Sant’Andrea Hospita. Rome, Italy. / Faculty of Medicine and Psychology. Sapienza University of Rome. Rome, Italy. / Pancreato-Biliary Endoscopy and Endosonography Division. Pancreas Translational and Clinical Research Center. IRSSC San Raffaele Scientific Institute. Milan, Italy. | pt_BR |
Affilliation | Genetic and Molecular Epidemiology Group. Spanish National Cancer Research Centre (CNIO). Madrid, Spain. | pt_BR |
Affilliation | Department of Biology. University of Pisa. Pisa, Italy. | pt_BR |
Affilliation | Genomic Epidemiology Group. German Cancer Research Center (DKFZ). Heidelberg, Germany. | pt_BR |
Subject | Pancreatic Neoplasms | pt_BR |
Subject | MicroRNAs | pt_BR |
Subject | Polymorphism, Genetic | pt_BR |
Subject | Genetic Predisposition to Disease | pt_BR |
Subject | Carcinoma, Pancreatic Ductal | pt_BR |
Subject in Spanish | Neoplasias Pancreáticas | pt_BR |
Subject in Spanish | MicroARNs | pt_BR |
Subject in Spanish | Polimorfismo Genético | pt_BR |
Subject in Spanish | Predisposición Genética a la Enfermedad | pt_BR |
Subject in Spanish | Carcinoma Ductal Pancreático | pt_BR |
Subject in French | Tumeurs du pancréas | pt_BR |
Subject in French | microARN | pt_BR |
Subject in French | Polymorphisme génétique | pt_BR |
Subject in French | Prédisposition génétique à une maladie | pt_BR |
Subject in French | Carcinome du canal pancréatique | pt_BR |
DeCS | Neoplasias Pancreáticas | pt_BR |
DeCS | MicroRNAs | pt_BR |
DeCS | Polimorfismo Genético | pt_BR |
DeCS | Predisposição Genética para Doença | pt_BR |
DeCS | Carcinoma Ductal Pancreático | pt_BR |